JCI Table of Contents, 15 August 2003
...ic development. It has also been shown to act as a coreceptor for Nodal, a member of the TGFbeta family. Cripto appears to recruit Nodal to the Activin receptor complex to mediate transcriptional responses. However there remains no explanation for the widespread overexpression of Cripto in human epithelial canc...JCI table of contents, 16 June 2003
...ry atresia. TITLE: Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease AUTHOR CONTACT: Terence Dermody Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Phone: 615-343-9943 Fax: 615-343-9723 E-mail: terry.dermody@vanderbilt.edu View the PDF of this ar...Researchers Discover How The Immune System Shuts Down Faulty T Cells
...d cytotoxic cells. Helper Tcells carrying the CD 4 coreceptor recognize antigen bound by class 2 MHCmolecules and trigger antibody production upon activation by foreign peptides.Cytotoxic cells carry CD 8, recognize antigen bound to class 1 proteins, andkill cells bearing foreign peptides. But nothing...Bowman Gray Scientists Find Novel Way To Block AIDS Virus
...dramatic discovery, a genetic defect in achemokine coreceptor was found to protect individuals with this defect fromHIV-1 infection. These genetically defective individuals remain healthy,because the usual functions of a defective chemokine receptor can be taken overby other receptors because of redundancies i...... for a pair of cell surfacereceptor -- CD4 and the coreceptor CXCR4 -- normally found on human T cells. These r... require loss of HIV's ability tobind CD4 or [the] coreceptor and would therefore not be selected," the authorswrite. Nava Sarver, Ph.D., chief of the targeted in...