Tag: "correction" at biology news

New Molecular Switch Is The Key That Unlocks DNA Repair

...he repair machinery which then orchestrates the correction of these errors. “Without hMSH2 or hMLH1 the cellular DNA becomes unstable [genome instability], errors accumulate and the result is cancer,” Dr. Fishel explained. In their experiments, the scientists measured the initial ...

Malthus + 200: Disastrous 'Correction' Looms

...y of the planet is finite, a disastrous Malthusian correction looms ahead," Price says, referring to T.R. Malthus' seminal "Essay on the Principle of Population." This dire outcome, says Price, is a possibility that no one wants to accept as an inevitable consequence of natural forces. On June 7 scholars aroun...

Novel Method Of Gene Replacement Reported By University Of Washington Researchers

... be cured with only modestimprovements in the gene correction rate. Many diseases could be cured if futureresearch enables us to correct genes in 10 percent of the targeted cells." As a vector, the researchers used a virus called adeno-associated virus2 (AAV), a single-stranded DNA virus capable of int...

Earlier Human Speech?

...lieve the slight overlap may occur because thesize correction is imperfect, or that variations exist in the sizes of thestructures that run through the canal. Because Neanderthals first evolved about 300,000 years ago, the Dukescientists' evidence disagrees with the theory that human speech may not have...

Avigen's Gene Therapy Approach Shows Promise In Treating Hemophilia B With Single Intramuscular Administration

...vations continuing. Researchers observed apartial correction of the whole blood clotting time and partial thromboplastintime, another laboratory test to measure clotting time. Also, there was notoxicity noted in treated animals. Hemophilia B Hemophilia B, the second most common severe genetic bleeding disor...

Scientists Use Gene Therapy To Correct Deafness In Mice

...gy. The U-M study represents the first permanent correction of a deafness-relatedgenetic mutation and the fift...s, National Institutes of Health, describe how the correction of thedeafness gene in shaker-2 mice helped them find a nearly identical gene (DFNB3)on human chromo...

Secrets Of The S.O.S Repair Service

... the regular repair enzymes, DNA has a last-minute correction mechanism known as the S.O.S. repair. In a study reported in the August 28, 1998 issue of MOLECULAR CELL (Vol. 2, pp. 191-199), Prof. Zvi Livneh of the Weizmann Institute's Biological Chemistry Department, with graduate students Nina Reuven and Guy T...

Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer

...repair machinery, withhMLH1, then orchestrates the correction of these errors. "Without hMSH2 or hMLH1the cellular DNA becomes unstable, errors accumulate and the result is cancer,"Dr. Fishel explains. Now the question is, will it work in humans?" says Dr. Fishel. "Wealready know there is some efficacy...

Successful Hemophilia B Gene Therapy In Dogs May Justify Human Experiments

...nimals with the condition to bleed. "The correction is modest, about 1 percent, but we believe that's ...gy at the UNC-CH School ofMedicine. "This level of correction in humans could be enough to improve certainpeople with severe hemophilia, who bleed spontaneously, ...

Bacteria From Gum Infections Associated With Diabetes, Chronic Lung Disease, UB Studies Find

...mdetachment than those with no lung disease, after correction for age, gender,race, ethnicity, education, income, frequency of dental visits, smoking andalcohol consumption. There also was a direct correlation between the amount of detachment andlung-disease risk. Subjects with gum detachment that exceeded 2 ...

Jefferson scientists further develop gene repair technique

... to treat diseasemore effectively. Though the gene correction may occur in only 5 percent ofcells for some disea...wer and betterchimera structures that improve gene correction frequency and will move ustoward cystic fibrosis and sickle cell anemia applications."...

SIDS prevention tactic leads to epidemic of 'misshapen head' in infants

...herapy isnecessary to correct the head shape. "The correction of head asymmetry with helmet therapy is based on head growth --the normal rate of growth slows at around one year of age, so we have a windowof opportunity when the baby is between six months and one year old," Dr. Grahamstated. In Niko's case, his ...

Duke scientists reverse a rare form of muscular dystrophy in mice using gene therapy

...me. "This is the firstexample of the simultaneous correction of multiple muscle groups after a single,simple, intra-venous administration of a gene therapy vector" Amalfitano said,"a hurdle that has always made the potential of gene therapy to treat musclediseases very difficult to envision." A.J. McVi...

UF research suggests widely used models may under predict pollution

...pounds to see if we can generate some kind of nice correction factor for the data used for these models," she said. Andino's research, part of a five-year project funded with more than $280,000 from the National Science Foundation, is in its third year. She received the grant as part of an NSF Faculty Early C...

Hopkins researchers identify neurologic problem associated with motor disorders in Huntington's disease

...ts that the basal ganglia may be involved in error correction because when it's damaged, error correction suffers," Smith says. Huntington's disease, also known as Huntington's chorea, is an inherited...

Inheritable gene modification research should not proceed on humans without standards and oversight, AAAS report says

...ot be initiated until reliable techniques for gene correction or replacement are developed that meet agreed upon standards for safety and efficacy. Serious ethical and religious issues also must be addressed as research policy is formulated, according to the report. IGM, for instance, raises questions of ju...

Florida scientists find enzyme replacement restores muscle strength in mice with Pompe's disease

...treatment for this disease has led to a functional correction of muscle strength," said Dr. Barry Byrne an associate professor in the College of Medicine's departments of pediatrics, and molecular genetics and microbiology. "The findings are preliminary and there's still a lot of work to do, but we're very enco...

New resources to assist with gene transfer clinical studies

...e to a part of the patient's body. This allows the correction of a genetic disorder or alteration of the properties of the cell. In this manner, gene transfer protocols, using several viral and non-viral vectors, have addressed such diseases as cystic fibrosis, severe combined immune deficiencies, hemophilia, c...

Testosterone dose-repsonse relationships in healthy young men

...by nuclear magnetic resonance spectroscopy, with a correction factor of 0.985 for exchangeable hydrogen. Another measure of bilateral leg press strength was taken by use of the one-repetition maximum (1-RM) method. A seated leg press exercise with pneumatic resistance was used for this purpose. Subjects perform...

Researchers identify potential for prenatal gene therapy

... heart, kidney, skin, and brain. Important for the correction of lymphohematopoietic genetic disorders, GFP expression was present in both the spleen and bone marrow, indicating that Sleeping Beauty can localize to hematopoietic organs in vivo. Details of Mortari's presenation: Time: Monday, December 10, 2001,...

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