New milestones on the path to conquering HIV drug resistance (AIDS)
...nal chemists, virologists, molecular modelers, and crystallographers from Rutgers and the NIH in the United States, as well as from Johnson & Johnson subsidiaries, Janssen Pharmaceutica in the United States and Belgium, and Tibotec-Virco, N.V. in Belgium. Several of the DAPY compounds have shown unprecedented results...UT Southwestern gets new cryo-electron microscope
...elop between the cryo-EM specialists and the X-ray crystallographers on campus."...Bacterial quorum-sensing structure solved
...ed the so-called TraR protein and sent it to X-ray crystallographers at Argonne. There, the protein was crystallized and examined in a synchrotron X-ray beam from the national laboratory's Advanced Photon Source. A sophisticated computer program then transformed millions of X-ray data points from the crystallized pro...... Dr. Andrew C. von Eschenbach, NCI director. X-ray crystallographers determine the three-dimensional shape of a molecule by blasting a beam of X-rays through a crystallized sample of the molecule and then analyzing the pattern of the scattered beam. X-rays are electromagnetic waves like light, except that their wavele...NIH funds synchrotron beamlines to advance studies of molecular structures
...rector of NCI's Division of Cancer Biology. X-ray crystallographers determine the three-dimensional shape of a molecule by blasting a beam of X-rays through a crystallized sample of the molecule and then analyzing the pattern of the scattered beam. Synchrotrons are powerful tools for such work, because they generate...X-ray crystallography at Advanced Photon Source
...nding out a signaling molecule. "Up to this point, crystallographers mostly looked at individual protein components. Now the focus is turning to looking at how these components assemble to perform their function," Ealick said. This research will be conducted taking advantage of what Ealick describes as "the extra bril...NY pilot study pushes Human Genome Project toward cures for disease
...chers fear that structural genomics will put X-ray crystallographers and nuclear magnetic resonance (NMR) spectroscopists out of business, Sali and his colleagues contend that technological advances will improve the efficiency of all structural biologists. They also argue that structural genomics may even provide the ...Stanford launches interdisciplinary initiative in the biological sciences
..., they deducedthe structure from the data of X-ray crystallographers by using rules governingchemical bonds that had been developed by chemist Linus Pauling, who had tappedthe principles of quantum mechanics. Channing Robertson, the Ruth G. and William K. Bowes Professor of ChemicalEngineering, a member of the four-pe...Unprecedented View Of RNA Structure Captured
...gors of analysis--in this case,conducted by expert crystallographers in a neighboring biophysics lab. When data analysis finally produced the images, showing details of RNA buildingblocks neatly arranged in a compact structure, the scientists were awed. Withinthe intricate RNA folds, they discovered protein clearly s...Sandia Discovery About Protein May Help Clean Up Pollutants, Find Cures For Diseases
...s, theyemerge in a crystalline form. Protein X-ray crystallographers then determine thepositions of the atoms in these very large molecules and deposit this structuralinformation in the Brookhaven Protein Data Bank. The structures can then be putinto the computer program, which quantifies the heme's nonplanar structur...Wonder Thread: UD Scientists Report First Protein With Collagen And Elastin-Like Domains
...k is so thin, it has been difficult for anyone but crystallographers to deal with it," he says. "Byssal threads could turn out to be an interesting substitute, or model for studying some aspects of spider silk." Curiously, the collagenous regions of preCol-P contain a missing glycine. "When a deletion like this is fou...