Researchers find color sensitive atomic switch in bacteria
...one billionth of a meter. "High-resolution X-ray crystallography revealed the light-absorbing part of the protein was present in two alternative positions, suggesting to us that light of different colors drives this protein back and forth between two differently colored states of the protein," said co-senior autho...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
... by this unique protein. In addition, using X-ray crystallography techniques, Schulman crystallized samples of the b...wever, images of the structure created using X-ray crystallography failed to provide detailed views of half of the individual amino acid building blocks making up the ...Protein fishing in America: The movie
...iques such as nuclear magnetic resonance and x-ray crystallography reveal structural details about proteins and positions of their atoms at a particular time in space. They provide structural reference points, but to contrive interactions, many images have to be gathered at different times, events averaged out and a...Images reveal how rotavirus - leading cause of diarrhea - enters cells
...ratory of Molecular Medicine, the researchers used crystallography and electron microscopy to determine the geometric structure and working parts of one of the virus's surface proteins, called VP4. Rotavirus itself is a large, soccer ball-shaped, 20-sided particle with three layers. "The outside layer is like a la...New drug shows promise against Gleevec resistance in mice
...informed guess based on what we were seeing in the crystallography data." As fate would have it, Bristol-Myers Squibb had a dual Abl/Src inhibitor under development. Sawyers received a phone call from Bristol-Myers Squibb and BMS-354825's reincarnation as a cancer drug was under way. As Sawyers is ...EC boosts European electron microscopy research
...tomography, single particle analysis, and electron crystallography will combine their expertise to reach a very ambitious goal: the three-dimensional (3D) imaging of macromolecules and molecular machines at atomic resolution, with the prospect of a 3D imaging of cell organelles and whole cells. The determination of...New milestones on the path to conquering HIV drug resistance (AIDS)
... of the problem in conjunction with Arnold's X-ray crystallography a method by which X-ray diffraction patterns obtained from crystals are used to map the three-dimensional atomic structure of large molecules. "We have been fighting this battle together for more than 15 years," said Hughes. "We are both very exci...New designed paclitaxel analog kills more cancer cells than natural product
...ocket has been visualized by some elegant electron crystallography experiments carried out by scientists at the Lawrence Berkeley National Laboratory (Nogales, Wolff Downing, Nature 1998, 39, 199-203). Paclitaxel consists of a rigid ring system attached to a flexible side chain, but the exact arrangement of the side...Yale scientists visualize molecular detail of RNA splicing complex
...he study and his research team at Yale, used X-ray crystallography to image the self-splicing group-I intron and the associations it makes as it reacts. The image shows an interaction with metal ions and the alignment of the RNA molecule segments. "The structure reveals how RNA, which is chemically very different f...Molecular image of genotoxin reveals how bacteria damage human DNA
... years to obtain the crystals she needed for X-ray crystallography - a technique that records the pattern produced when X-rays bounce off a target protein crystal. "You have to find the right conditions and the right concentrations for crystallization," said Nesic. "You start with liters, and you end up with a singl...Ferr-D'amar wins 2004 Eli Lilly and Company Research Award
...rlier methods. He then used the technique of X-ray crystallography to study the three-dimensional structures of RNA and RNA-protein complexes, focusing on RNA taken from a plant virus, as well as RNA from the hepatitis delta virus, which is pathogenic to humans. Ferr-D'Amar's second groundbreaking achievement ...St. Jude researchers create image of enzyme that orchestrates natural genetic engineering
...evelop cancer. White used a modified form of X-ray crystallography to create images of UvsW. In this technique, a crystallized sample of a protein is bombarded with a beam of X-rays. The pattern formed by the diffraction of the beams off the crystal is used to create a computer-generated, 3-D image of the protein. T...New paclitaxel analog kills more cancer cells than natural product
...ocket has been visualized by some elegant electron crystallography experiments carried out by scientists at the Lawrence Berkeley National Laboratory (Nogales et al., Cell, 1999, 96, 79). Paclitaxel consists of a rigid ring system attached to a flexible side chain, but the exact arrangement of the side chain in spac...... of protein-structure determination, such as x-ray crystallography -- where the pattern of x-rays scattering off atoms in crystallized proteins is used to determine structure. It will be particularly useful for proteins that are impossible or difficult to crystallize, such as those that control the movement of molec...Green Foundation, Trust gives $12.8 million for UT Southwestern comprehensive research center
...gy and biochemistry." Scientists now can use X-ray crystallography and magnetic resonance spectroscopy to solve the three-dimensional structures of important biological molecules especially proteins, Dr. Gilman noted. The newest computer-assisted imaging technologies also allow precise visualization of cell structu...New systems biology center positions UT Southwestern in vanguard of scientific research
...ude very talented scientists in the areas of X-ray crystallography and nuclear magnetic resonance spectrometry. This ...protein works in an organism. Beginning with X-ray crystallography data, Dr. Ranganathan's group used advanced computer science and mathematics to determine the three-...RNA inner workings partly unveiled in Stanford study
...ntist Mike Soltis, PhD, head of the macromolecular crystallography group. "With the new system, the Kornberg group screened 130 crystals in seven hours without losing any. Two weeks earlier, they had manually mounted 100 crystals in 24 hours, losing a few crystals and much sleep in the process." The Kornberg group...European researchers launch 10 million euro collaborative technology project
...le and efficient management structure. Biological crystallography aims to create precise, three-dimensional "architectural" models of biological molecules. Without such models at hand, it is close to impossible to understand biological processes, for instance the way proteins and other molecules behave in cells, or...Researchers determine reason for deadly spread of 1918 influenza
...protein and used the analytical technique of x-ray crystallography to determine its structure. "The structure revealed how this H1 group could still resemble the avian binding site, but nevertheless infect humans," said Skehel. "We found basically that two sides of the hemagglutinin receptor binding site are in slig...Seeing how plants split water could provide key to our future energy needs
...luding those obtained using lower resolution X-ray crystallography at 3.7 angstroms have shown that the splitting of water occurs at a catalytic centre that consists of four manganese atoms (Mn)," explains Professor So Iwata of Imperial's Department of Biological Sciences. "We've taken this further by showing that t...