Jefferson Researchers First To Create Genetically Engineered Mouse To Study Photoaging
...r and chairmanof the department of dermatology and cutaneous biology at Jefferson MedicalCollege of Thomas Jeff...essor in Jefferson?s department of dermatology and cutaneous biology. Dr. Gasparro, an expert in photobiology, and author of the newlyreleased book, Su......-au-lait spots’) and neurofibromas, benign cutaneous tumors, are hallmarks of NF1 with important diagnostic relevance. In rare cases, NF1 may develop into malignant tumors. The so-called NF1 gene is responsible for the development of the disease. It codes a huge protein, termed neurof......tratumoral administration for patients with either cutaneous or subcutaneous solid tumors. Patients will be evaluated for the accumulation of VNP20009 in the tumor and non-injected lesions. Patient accrual continues for this trial, which may involve up to 20-30 patients. TAPET (Tumor Amplified Protein Expres...Jefferson scientists use gene repair technique to change albino mice hairs to black
...oon, Ph.D., associate professor of dermatology and cutaneous biology and biochemistry and molecular pharmacology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and postdoctoral fellow Vitali Alexeev, Ph.D., in collaboration with a team of scientists at the University of Pennsylvani...Researchers successfully immunize mice against aggressive cancer
..., interim chief of the division of dermatology and cutaneous surgery at Shands at UF health center. "The possibility of preventing this cancer through immunization would be a fantastic way of reducing both morbidity and mortality associated with melanoma. "It will put me out of business, but that's fine," he s......isk for vitamin D deficiency could be due to lower cutaneous synthesis of vitamin D3 as a result of increased skin pigmentation. Obesity was associated with vitamin D deficiency in the less-disabled group but not the more-disabled group. In the less-disabled group, obesity may have been more of a defining fac...Component of fly saliva makes promising Leishmaniasis vaccine
...f Leishmania major, a parasite species that causes cutaneous leishmaniasis. The researchers separated the prot...tect mice from the severe symptoms associated with cutaneous leishmaniasis, perhaps by mimicking natural immunity to the infection. "People get bitten by infect...Other highlights in the Jan. 16 issue of JNCI
...o repair DNA damage is associated with the risk of cutaneous malignant melanoma. By studying 132 patients with melanoma and 145 control subjects, the authors found that, independent of other risk factors, DNA repair capacity was not associated with an increased risk of melanoma. However, among patients who had...Fox Chase Cancer Center offers topical gel to treat precursor to skin cancer
...asis is a skin condition considered a precursor to cutaneous T-cell lymphoma, (CTCL) which is a potentially deadly form of cancer that manifests in the skin and targets the bodys white blood cells (lymphocytes), impairing the patients immune system. Despite its name, parapsoriasis differs from psoriasis in it...CDC MMWR: Fetal Alcohol Syndrome and Cutaneous Anthrax in a Lab Worker
.... Drs. Rosenstein and Page will discuss a case of cutaneous anthrax in a Texas lab worker. The lab worker may have become infected because of a skin exposure to a contaminated surface. WHEN: Thursday, April 4, 2002 12 Noon - 12:15 PM ET Fetal Alcohol Syndrome 12:15 12:30 PM ET Anthrax Brief rem...Anthrax drugs used to treat adults can treat children, too
...Nahata said. Fatality from the cutaneous form of the disease is lower: 20 percent ... "Nor do we know the likelihood of cutaneous anthrax progressing into a systemic infection or, worse yet, meningitis." ...New methods for detecting brown recluse spider venom
... in New York when a 7-month-old who had contracted cutaneous anthrax was initially diagnosed as having a brown recluse spider bite, even though these spiders are not native to New York. (The Diagnosis of Brown Recluse Spider Bite Is Overused for Dermonecrotic Wounds of Uncertain Etiology) Two new studies in th...Mathematical model provides new tool to assess mail-borne spread of anthrax
...halation of anthrax spores and sevenwere caused by cutaneous (skin) contact. Five of the people who inhaledanthrax have died: a photo editor in Florida, two postal workers and twowomen who had no apparent association with the original letters. Thefederal task force investigating the cases reports that four of ...Researchers aim to control treatment-resistant head lice
...in this whole aspect of bioterrorism, particularly cutaneous anthrax," Clark pointed out. "You'd have a lot of ...eding lice], and somebody comes and dumps a lot of cutaneous anthrax on everybody, there's a real chance that these kids can be at high risk for infection," Clar...Drinking through your pelvic region?
...very much more rapid than mammals, the increase in cutaneous blood flow has been hypothesized to provide a supp...rior to initiating behavior that will increase the cutaneous area available for water absorption. It is noteworthy that red cell velocity reaches maximal values ......cells virtually untouched. The study will focus on cutaneous (skin) lesions metastasized from various cancers such as breast, lymphoma, head and neck and non-melanoma skin cancers. In this Phase I trial, researchers try to determine the maximum dose of the drug that can be tolerated by the patient and toxic s...Modern blood vessel measurements test belief that magnetic fields can influence blood flow
...sted that magnetic field application can influence cutaneous circulation and blood pressure in rats, but little information is available regarding the impact of magnetic fields on microvascular blood flow in general, and resistance arterioles in skeletal muscle in particular. Changes in microvascular tone hav...Location of ulcerations in diabetic patients may be explained by blood flow
...y provide insight into re-ulceration issues, since cutaneous perfusion is suspected to be influenced by arterial circulation but and the mechanical effects of repetitive pressure. Background Type II diabetes is related to poor glycemic control and if uncontrolled, leads to microvascular and neuropathic ......s -catenin protein is activated. Thus, through the cutaneous application of 4-OHT, the researchers could transiently activate -catenin signaling at will. To test the effect of -catenin signaling on adult hair growth, the researchers shaved the backs of telogen-phase transgenic and wild-type mice, and then app...DNA arrays diagnose, predict survival for Sezary syndrome cancer patients
... syndrome is a leukemic variant of a cancer called cutaneous T-cell lymphoma, or CTCL. The skin-associated variant of CTCL, mycosis fungoides, is the more common form of the disease. It is relatively easy to treat if diagnosed early in its course, but because its appearance is similar to that of many benign sk...