A novel, safer strategy for regulating gene expression
...he protein encoded by that gene. When the ribozyme cuts itself in half, the mRNA is cut in half, too disabling it and, in effect, turning off the gene. Inhibiting ribozyme breakage, which can be done with various drugs, leaves the mRNA intact; this allows the gene to turn "on" and make the desired protei...Possible new cure for psoriasis
...in, APP. The keratinocytes produce an enzyme which cuts the APP down to size as sAPPa: this is known as the a-secretase. Professor Herzog's research team has now blocked these 'molecular scissors'. 'We knew that certain metalloproteinase inhibitors impede the a-secretase. After adding these substances we...Research reveals role of gene in infertility
...amed SPO-11, that disables the protein system that cuts chromosomes. "In plants that are defective in both SPO-11 and RAD51, we find intact chromosomes, not the jumble of chromosome fragments," Ma reports. "Because the chromosomes are not cut in the first place, you don't really need the RAD51 to repair...Virginia Bioinformatics Institute researcher advances fight against sudden oak death disease
...ction spreads around the trunk's circumference and cuts off food supplies coming to the roots from the leaves, eventually killing the roots. Thus, the tree's death begins with the roots, causing the upper tree trunk, bark, limbs and leaves to die from lack of water. The genome sequence of P. ramorum will...Gene defect linked to premature aging
... with a cell death process called apoptosis, which cuts the DNA into a million pieces, this aging process, called replicative senescence, lets the cell live for a limited period of time with a reduced number of cell divisions before it ages and dies. The researchers are beginning to screen compounds for a...U.S. President's budget proposal means 5-year cuts 'well below historic levels'
...esident Bush is proposing a budget that would mean cuts in research and development (R&D) funding for all ...S, the non-profit science society. "The projected cuts to most nondefense R&D programs would leave key programs with budgets well below recent historical l...New proteomics core at OHSU will speed discovery process
...with fluorescent stains to enhance their identity, cuts the samples from the gels, and breaks them down with enzymes, preparing them for closer examination with the mass spectrometer. It can process up to 192 samples at a time. "Each spot represents a protein," Bystrom explains, pointing to a gel sampl...Purdue engineers develop quick, inexpensive method to prototype microchips
...Huang, a graduate student in chemical engineering, cuts that time to hours. Microchips have traditionally been made through a lengthy and expensive process called photolithography, which uses X-rays or ultraviolet light to form a pattern on a glass or silicon wafer that is then etched by washing the waf...UC Riverside researchers publish paper on botulism detection system
...ilever comes in contact with the neurotoxin, which cuts through the protein strands connecting the two, much like a fish would cut through a fishing line. The bead's separation causes the cantilever to vibrate, announcing the neurotoxin's presence. While effective, the process is not yet ready for practic...Study finds that fungus farming by snails causes marsh grasses to wither
...ts band of saw-like teeth and creates longitudinal cuts in leaf surfaces, making a much larger meal possible. While it travels, the snail also deposits feces laden with fungal spores and nutrients into the sensitive inner-tissue of the leaf, effectively stimulating and fertilizing fungal crops. The result...Work begins on powering a sustainable future for the UK
... and each will run for four years. This research cuts across many disciplines incorporating political, social, environmental and economic factors covering climate change, fossil fuel extraction rates, emissions control and increasing public awareness of environmental concerns. The multidisciplinary natu...Researchers solve the mystery of a key structure in immune system cells
...y of T-cells to antigen, but beyond a threshold it cuts off signaling to prevent T-cell death," explains Dr. Chakraborty. "We only realized this with the use of a computational analysis that allowed us to see how all these different variables were playing out," added Dr. Shaw. "It's hard for most of us ...Ancient Inca road in desperate need of protection
...ttoral and the Chilean Winter Rain Forest. It also cuts through some of the last remaining habitat of the spectacled Andean bear, the Andean condor and the vicua South America's smallest camelid that was almost hunted to extinction in the 1960s and 1970s. The study found that revitalizing the Gran Ruta w...U.S. Army awards veterinary college researcher $1 million grant to develop vaccine
...king water. Humans are also infected through minor cuts or abrasions on the hands by handling infected animals. The military is concerned about F. tularensis because of its heartiness and its virulence. Whereas about 10,000 Bacillus anthracis (anthrax) spores are required to cause disease, only about 10 ...Hospitalized children experience medical errors at the same rate as adults
...ve everything from medication errors to accidental cuts and fractures during a procedure. "The ability to provide the safest medical care is shifting from an emphasis on expecting perfection in individuals, to changing those systems in which they work, reducing risks by factoring in their possibility at ...Protein critical for development in fruit flies found to aid healing of cuts and wounds in mammals
...used by mammals to assist in the timely healing of cuts and lacerations. Their discovery, detailed in the ...will be able to improve their ability to heal from cuts and lacerations." The researchers in the Johnson lab were assisted by Kit Pogliano, an associate pro...Researchers discover important genetic flaw in family affected by schizophrenia
...nt in brain development and behaviour--are broken, cuts off important functions of the corresponding protein, particularly the ability to bind to DNA. Binding to DNA is an important way proteins can control the expression of other genes," says Professor Diane Cox, Chair of the Medical Genetics Department....Gene enhances prefrontal function at a price
...met genetic variation, or polymorphism, is that it cuts both ways. NIMH's Weinberger says preliminary evidence suggests that having even one met predicts a better response on working memory tests in schizophrenia patients after treatment with an antipsychotic medication. Moreover, there is new evidence ...A kindler, gentler cut for LASIK
... femtosecond lasers can make clean, high-precision cuts in the human cornea that offer superior reliability and fewer complications than cuts made with mechanical devices now used in most LASIK procedures. Results of the study were published ...Widespread cannibalism may have caused prehistoric prion disease epidemics, Science study suggests
...istoric populations practiced cannibalism, such as cuts and burn marks on Neanderthal bones, and biochemical analysis of fossilized human feces. "There is extensive anthropological evidence that cannibalism is not just some rarity that happened in New Guinea," Collinge said....