New way to lock DNA-slicing enzyme onto chromosomes could lead to novel anti-cancer drugs
... CPT works only during the part of the cell's life cycle called S phase, when the cell synthesizes duplicate chromosomes. Because the new strategy can work whether the cell is in S phase or just decoding a single gene, a drug based on this approach could be particularly versatile. "What's particularly exc...NASA scientists discover spring thaw makes a difference
... a year since 1988, has the potential to alter the cycle ofatmospheric carbon dioxide intake and release by vegetation and soils across the region, potentially resulting in changes in Earth's climate. The lengthening growing season appears tobe promoting more carbon uptake by the vegetation than is being r...Hope available for patients with anemia and myelodysplastic syndrome
... heterotypic (different in kind) adhesion and cell cycle arrest, sensitization to death-receptor induced programmed cell death, abrogation (abolishment) of cellular response to receptor-initiated mutations signals, and suppression of inflammatory cytokine (a class of immunoregulatory proteins secreted by c...Growth hormone activates gene involved in healing damaged tissue
... Foxm1b gene, which is involved in the entire life cycle of the mammalian cell -- its proliferation, maturation and death. The gene's activity is elevated in dividing cells in young mammals but diminishes in old age. In previous studies, the researchers inserted the human Foxm1b gene in aged mice whose li...Researchers call for trials of menstrual cycle monitors used for natural family planning
...ated 30-40 per cent rely on some type of menstrual cycle monitor to detect the fertile 'window' in their me...ed that the woman was in a non-fertile part of her cycle while the worst was wrong nearly three-quarters of the time. By contrast, the symptothermal method, ...Green and sustainable chemistry
...urces and the discharge of wastes through the life cycle of chemical products and processes, and to secure the health and safety of mankind and the environment. Green Chemistry is a peer-review journal focussing on all research that attempts to reduce the environmental impact of the chemical enterprise by ...Global wetlands surveyed from space
... important roles in terms of biology and the water cycle has grown, spurring international efforts to prese..., topography dynamics and subsidence layers, water cycle and quality maps. "In co-operation with the Spanish regional authorities involved in nature conserv...Duke researchers link nitric oxide, vessel health
...group during six months of exercise carried out on cycle ergometers, treadmills or elliptical trainers in a supervised setting. After six months, the researchers performed the same series of ultrasound and biochemical tests again. After the exercise period, the at-risk patients had a significant increase i...Protein involved in cell division now found key to cell growth
...3 protein, a tumor suppressor that blocks the cell cycle if the cell starts to grow erratically. Abnormally...evelopment," says Zhang. "ARF can inhibit the cell cycle by activating p53 and can also inhibit cell growth by inhibiting B23."...Breast cancer susceptibility genes play role in DNA repair
...n essence, BRCC puts the brakes to the cell's life cycle to allow DNA repair to commence before cell divisi...terfered with the ability of BRCC to halt the cell cycle at the checkpoint before cell division. Shiekhattar and his colleagues found that certain sporadic ...New drug target and biomarker for advanced childhood cancer discovered
...art of our broad-based development program in cell cycle directed therapies, we've determined the crystal structure of Aurora A kinase, and have been able to use this to develop selective and potent inhibitors of Aurora kinase activity," said Dr. Nick Keen, associate director, cancer & infection, AstraZene...Proteins may help identify patients who will respond better to treatments in certain cancers
...ion of proteins involved in the regulation of cell cycle progression, proliferation, or apoptosis (programmed cell death), which are known to affect the way that a tumor responds to radiotherapy. "We are using new strategies for data analysis to exploit the potential of molecular markers," said Francesca ...Circadian clock genes may provide targets for new cancer drugs
...d Period2 (per2) controls the circadian or 24-hour cycle in the cells of mice. In the laboratory of the molecular and human genetics department at Baylor College of Medicine in Houston, Loning Fu, Ph.D., assistant professor, and her colleagues have shown that mice that lack this gene are prone to developi...Moderate alcohol consumption after meals can decrease levels of insulin
...isms that do not require oxygen. "The glyoxylate cycle is an energy system that can convert fat into carbohydrate," she said. "The glyoxylate cycle does not require thiamine, utilizes acetate as an energy source, and can be switched off by glucose....Nicotine exposure in aging hearts
... was tested by a rapid, 3-s burst atrial pacing at cycle lengths (CL) of 100 ms with a pulse duration of 2 ms and twice-diastolic current threshold. The effective refractory period (ERP) was measured by the S2 extrastimulus method using eight regularly paced S1-S1 at a pacing CL of 200 ms in the right atri...With flu season coming, don't forgetexercise?
...n. They were maintained on a 12:12-hour light-dark cycle in a low stress environment and given food (chow) and water (oat -glucan dissolved in water) ad libitum. Separate groups of mice were used for each dependent variable: in vivo susceptibility to infection (n=24 per group), macrophage anti-viral resis...Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
...his fails, the system halts the cell's replication cycle and causes the new cell to die--literally, to pop ...smatch-repair system to interrupt the reproductive cycle and cause apoptosis. "Our finding that the defective MED1 enzyme produces resistance to these drugs ...Isotopes from feathers reveal bird migration
...rally found in molecules of rain water. But as the cycle of evaporation and precipitation repeats across North America and over mountainous regions, the heavier deuterium isotopes get left behind. That creates well-mapped hydrogen/deuterium trends across the continent, Duxbury explains. "There is a well kn...Red sea urchins found to live up to 200 years
...hallenge some erroneous assumptions about the life cycle of this never-say-die marine species. It used to be believed that red sea urchins lived to be only seven to 15 years of age, experts say. But the newest findings are based on the use of two completely different techniques of determining sea urchin a......iseases to be studied in the centers include: urea cycle disorders; Angelman's syndrome; Prader-Willi syndrome; Rett syndrome; periodic paralysis; non-dystrophic myotonic disorders; episodic ataxia; aplastic anemia; paroxysmal nocturnal hemoglobinuria; single lineage cytopenias, including granular lymphocy...