Tag: "cystic" at biology news
A new approach holds promise for reducing cocaine craving
...ng drug n-acetyl cysteine, which is used to treat cystic
fibrosis and several other disorders reverses the changes in brain chemistry that appear to cause cocaine craving," said David A. Baker, a post-doctoral fellow in the laboratory of Peter W. Kalivas at the Medical University of South Carolina. Baker ...
Wake Forest, Pittsburgh doctors find gene behind two kidney diseases
...appears responsible for a disease called medullary cystic
kidney disease Type 2 in another family. "The...y which produces gout at an early age. Medullary cystic
kidney disease, which produces cysts in the middle of the kidney. Bleyer said that doctors had ...
Alternative treatment for secretory diarrhea linked to the cystic fibrosis gene
...moval of water from the circulation. In 1989 the cystic
fibrosis gene was identified and found to encode a...hannel in cells lining the lung. Recognized as the cystic
fibrosis transmembrane conductance regulator (CFTR), no compounds were known to inhibit the activity...
JCI Table of Contents, December 2, 2002
...ive treatment for secretory diarrhea linked to the cystic
fibrosisgene Secretory diarrhea is the leading ca...removal of waterfrom the circulation. In 1989 the cystic
fibrosis gene was identified and found to encode achloride channel in cells lining the lung. Recogni...
U.S.-German research consortium sequences genome of versatile soil microbe
...nistic pathogen and the leading cause of death for cystic
fibrosis patients. TIGR evolutionary biologist Jonathan Eisen said, "Such comparisons among closely related species with different biological properties are invaluable in learning about the biology of each species. In this case it allows us to better...
International consortium launches genetic variation mapping project
...y rare disorders, such as Huntington's disease and cystic
fibrosis. These diseases are caused by variants in single genes that tend to have a big impact on health, making the genetic contributions to the illnesses relatively easy to find using current methods that rely on gathering family information, or pe...
New screening technique may speed hunt for genes
...genes involved in a few inherited diseases such as cystic
fibrosis have been identified, many have not. Now, two scientists say they may have found a way to make the search more economical and speed it up. In an article to appear online in the Proceedings of the National Academy of Sciences next week, scie...
World-first gene therapy for cystic fibrosis targets lung stem cells?
The genetically inherited disease cystic
fibrosis causes severe, unrelenting lung disease i...novel system of gene therapy for lungs affected by cystic
fibrosis, involving a natural compound found in our lungs which 'conditions' lung airways to allow c...
Cystic fibrosis gene mutations missing from some cases
...ns Hopkins finds that some patients diagnosed with cystic
fibrosis (CF) lack any of the more than 1,000 repo... discussion about what is, and is not, non-classic cystic
fibrosis," says Garry Cutting, M.D., director of the DNA Diagnostic Lab at the McKusick-Nathans Inst...
Special report: Personal genomics
...genes that cause relatively rare diseases, such as cystic
fibrosis, but we're still in the dark about mutations that predispose people to more common problems- cancers, heart conditions or mental disorders such as schizophrenia. "We are really just at the beginning of the field," says David Reich of the Whi...
Stanford researchers develop gene therapy technique that sharply cuts risks
...nique for use in Duchenne's muscular dystrophy and cystic
fibrosis, among others....
Purdue corrals new Trojan horse to replace wayward genes in mice
...h as correcting the genetic defect responsible for cystic
fibrosis. It also can be used to alter or destroy defective cells, which makes gene therapy a possible treatment method for cancer. Viruses play a key role in this fledgling field because of their natural ability to transport and transfer genetic mat...
Findings aid understanding of neurodegenerative diseases
...arkinson's, Alzheimer's and Lou Gehrig's diseases, cystic
fibrosis and Creutzfeldt-Jakob disease, the human form of mad cow disease. The findings, which will be published in the Oct. 1 issue of Nature Cell Biology, could lead to an understanding of how to prevent these diseases and to the development of ef...
Study: Genome-wide scanning unravels complex birth defect
...he genetic causes of single-gene diseases, such as cystic
fibrosis, or one gene at a time for genetically complex diseases. "In complex diseases like diabetes and heart disease, the genes involved are probably scattered throughout the genome, so you need to be able to look at the whole genome at once and p...
Stanford researchers devise novel gene therapy technique
...e responsible for Duchene's muscular dystrophy and cystic
fibrosis, but it causes the gene to integrate into human chromosomes in locations where it will continue to make protein as long as the cell is alive. In other techniques, the inserted DNA does not become part of the chromosome and eventually breaks ...
Smithies wins top award from Massry Foundation
...utations that model human genetic diseases such as cystic
fibrosis, some forms of anemia, high blood pressur...f which simulate human disease states -- including cystic
fibrosis, atherosclerosis, muscular dystrophy and cancer. "The creation of these mouse models strain...
Study finds link between common neurological disorder and Alzheimer's disease
...omatosis is a common disorder, more prevalent than cystic
fibrosis, muscular dystrophy, Huntington's disease, and Tay-Sachs disease combined. It can cause tumors along nerves throughout the body and can affect the development of non-nervous tissues such as bones and skin. The disease can also cause learning...
New technique shows how cells interpret genetic information
... The severity of certain genetic diseases, such as cystic
fibrosis, varies tremendously depending on the patient's genetic background. In other words, the severity of the disease in two people with the same genetic defect might be quite different because of differences in other genes. Ares said differences ...
Enzyme could aid cancer fight
...ptibility to serious diseases such as haemophilia, cystic
fibrosis and cancer. Teams at Cardiff University, Wales, and the University of Edinburgh, Scotland, who discovered a gene repair mechanism called the MBD4 enzyme in 1999, have now found that gene mutations are up to three times more common in mice la...
Bacterial quorum-sensing structure solved
...ne kind of bacterial biofilm smothers the lungs of cystic
fibrosis victims. Knowing the configuration of an essential quorum-sensing protein might permit structure-based design of a drug to block the chemical signal before bacteria join in a drug-resistant biofilm. Conversely, the rapid formation of useful ...
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