Tag: "defects" at biology news

Brain Protein "Rescues" Neurons From Atrophy

...om their experiments, the scientists theorize that defects in the cell's neurotrophin machinery likely play a..., form and maintain connections might be traced to defects in neurotrophin signaling," Katz said. "These disorders might include certain forms of mental retard...

Bacterial Toxin Surprises Scientists

...ases like cystic fibrosis that result from defects in natural membrane channels. "If we could understand how this protein works, we might understand more about how proteins are normally moved across and inserted into membranes," said the study's lead scientist, Dr. A...

Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease

...covery may provide a clue to the underlyinggenetic defects that can lead some people's immune systems to atta... that appears to regulateTNFa. It is possible that defects in this gene may cause people to be susceptibleto developing autoimmune diseases." The correspondi...

Duke Researchers Find Second Gene Linked To Blood Vessel Disorder

...has shown that families whose disease is linked to defects in theendoglin gene have an increased risk of developing lesions in their lungsthat can lead to serious, secondary neurological problems. About 30 percentof people with this form of HHT develop these lung problems. "We are developing a genetic scr...

International Research Team Clones New Skin Cancer Gene

... thousands of skin cancers and may also have birth defects and childhood brain tumors. In 1992, Bale mappe...in fruit flies were strangely similar to the birth defects in NBCCS", said Bale. The researchers found that individuals with NBCCS are born with a mutation of ...

Newly Discovered Gene Halts Cell Division and May Have Cancer Link

...able breast, ovarian, and prostate tumors may have defects in the gene, known as MAD2. The new discovery may open the door to finding more effective ways to treat such tumors. "We think the MAD2 gene stops cells from dividing when doing so would leave the newly formed daughter cells without all the chromoso...

Cholesterol Anchor Helps Signaling Proteins Direct Development

... suppressing cholesterol production leads to birth defects in animals; the new work suggests that this may be because lack of cholesterol interferes with the production of hedgehog protein or with the way it spreads through tissues. "While I do not suggest that expectant mothers switch to a high-fat diet, b...

Scientists Bridge Gap In Cell Communication

...ocess that, if disrupted, can result in cancer and defects in embryonic development. By revealing the terminus of the pathway by which cells send and receive messages, the find promises a rational basis for the future treatment of some diseases and, more immediately, gives science a new grasp of a p...

Newly Discovered Human Protein Provides Important Target For Cancer Therapy

...t. They created novel yeast mutants with specific defects in theirability to replicate telomeres. Shortly thereafter, both the Whiteheadresearchers and a team led by Drs. Joachim Lingner and Thomas Cech of theUniversity of Colorado, Boulder, and Dr. Victoria Lundblad of the Baylor Collegeof Medicine in Ho...

Folic Acid Fortification Effective In Cereal Grains

...heincidence of pregnancies affected by neural-tube defects and to possibly reduce occlusive vasculardiseases by lowering plasma and serum homocysteine concentrations." He noted: "The fortification of staple foods with folic acid may be the most practical and feasiblemeans to increase folate intake in the pop...

Peutz-Jeghers Disease Gene Identified: Enzyme Loss Causes Polyps And Cancer

...d the linkage to chromosome 19p13.3, also found defects in the STK11 gene in 11 out of 12 Peutz-Jeghers families. The STK11 coding region had initially been cloned by Jun-ichi Nezu from Chugai Pharmaceuticals, Japan, as a new member of the large protein kinase family. Protein kinases ar...

Getting At The Components Of Mechanotransduction: Genes Required For Vertebrate Sensory Hair Cell Function Identified

...eral nervous system. Localization of the defects to the sensory hair cells or primary neurons in...y similar to inner ear sensory cells) narrowed the defects down to the level of mechanotransduction in five of the mutants. Future work will be devoted t...

Yale Announces New Biotech Firm

...te cancer, refining techniques for locatinggenetic defects on chromosomes, studying receptors in the brain as...tics to unravel the causesof diseases that involve defects in multiple genes. MSI, which is developing new methods important in diagnosingcancer and de...

Adults Need To Increase Intake Of Folate; Some Women Should Take More

... amounts offolic acid. Neural tube defects -- such as spina bifida -- result from a disruptio...rmation of the central nervous system, neural tube defects mayappear as incomplete closure of the spinal column or even the absence of part ofthe brain. In th...

Renowned Breast Cancer Experts Present Latest Findings At UCSF Cancer Center Symposium

...riginallyreported. Struewing is now studying BRCA defects in Iceland, where populationcharacteristics offer unique advantages to genetics researchers. Long known as a major center for basic cancer research, UCSF is workingto enhance clinical research by arranging to provide access to both clinicalca...

Fetal Lead Exposure May Reduce Immunity

... system -- produce serious long-term immune system defects as the young rats mature," says Rodney R. Dietert, professor of immunotoxicology in Cornell's College of Veterinary Medicine. "These are immune changes that could increase their risk for allergic disease while reducing their immunity to tumors." The...

Mice Lacking The Pax8 Gene Suffer From Hypothyroidism And Fail To FormThyroxin-Producing Cells Of The Thyroid Gland

...rotein develop hypothyroidism may indicate similar defects in human patients. Researchers at the Department of Molecular Cell Biology, MPI for Biophysical Chemistry, Goettingen, Germany, report their findings in the May issue of Nature Genetics (vol. 19 (1) May 1998). ...

False Security: You Can't Always Believe The Results Of A Genetic Test

...d with mucus and prone to infections, is caused by defects in a single large gene. There are hundreds of these mutations. Some are very rare, and certain mutationsare more common in particular ethnic groups. To be effective, the widespread screening urged by the NIH panel would have to test for many ...

Gene May Hold Key To Treating Life-Threatening Cholesterol

...ions in LXR-alpha also may help identify inherited defects in cholesterol metabolism. "This study suggests that we can develop an excellent drug to treat high levels of dietary cholesterol by altering the molecules that bind with LXR-alpha. Now we will use different levels of dietary cholesterol in longer-te...

Scientists Use Gene Therapy To Correct Deafness In Mice

... generations, shaker-2 mice are born with innerear defects which cause deafness and balance abnormalities. In a paper published in the May 29 issue of Science, U-M scientists describe howthey used transgenic technology to find the recessive mutated gene responsiblefor deafness in shaker-2 mice. By injecting...

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