Gene therapy reduces drinking in rats with genetic predisposition to 'alcoholism'
...the brain have been postulated to lead to a reward deficiency syndrome that predisposes certain people to addictive behaviors, including drug and alcohol abuse. The alcohol-preferring rats used in this study have about 20-25 percent lower levels of dopamine D2 receptors when compared to the non-preferring rats,...Moderate iron deficiency affects cognitive performance - but iron supplementation improves it
...ys the study shows that even modest levels of iron deficiency have a negative impact on cognitive functioning in...ys Dr. Murray-Kolb, because the prevalence of iron deficiency remains at 9 percent to 11 percent for women of reproductive age and 25 percent for pregnant women. ...Estimated one in five people worldwide lack enough zinc in diet
...gumes and whole grain cereals as contributors to a deficiency problem much more common and harmful to health in ...says the magnitude and associated problems of zinc deficiency have been poorly understood in the past. It sheds new light on the importance of zinc to human heal...Study reveals important new factor in cystic fibrosis lung inflammation
...en with CF. The Cincinnati Children's team found a deficiency in the airways of children with CF of a class of molecules called lipoxins, which are key regulators of inflammation. "When we give analogs of this molecule (lipoxin-like molecules) in mouse models of CF, the molecules do what we'd like them to do -...New approach limits damage after heart attack and improves survival, say Scripps Research scientists
...ertain proteins belonging to the Src family have a deficiency in vascular permeability. These animals showed a high degree of resistance to the damaging effects of a heart attack. Src, it turns out, is necessary for breaking the cadherin junctions in response to VEGF. In fact, these mice lacking Src were protec...UT Southwestern research halts narcolepsy symptoms
...t researchers believe that in humans, a lack of or deficiency in orexin causes narcolepsy, a rare disease in whi...escued" the orexin knockout mice from their orexin deficiency and relieved their narcoleptic symptoms in two different ways. One method involved genetics, the o...Scientist works to interrupt early changes resulting in diabetic vision loss
...in synthesis, is disrupted in diabetes as well. A deficiency in folate can precipitate an increase in the level of homocysteine, an excitatory amino acid that, like glutamate, can stimulate the NMDA receptor. Additionally, high glucose may impair other transporters found on supportive cells such as retinal Mu...Possible link discovered between gene responsible for blood vessel development and ACD in newborns
...tant animals' offspring. They discovered that this deficiency caused major defects in the lung, resulting in respiratory distress and death. Tests showed that small blood vessels and capillaries were not formed properly and there was a misalignment of pulmonary veins, features that are shared by newborns with A...Crucial brain development gene identified
...Dr. Vasioukhin and colleagues determined that Lgl1 deficiency leads to a loss of apical/basal polarity in neural progenitor cells, failure of these cells to differentiate into more specialized cell types, and an overall increase in proliferation by the neural progenitor cell population. The researchers believe ...Duke open-air experiment results could deflate hopes that forests can alleviate global warming
...ents," he added. Apart from the impact of nitrogen deficiency and drought, the scientists have found some indication that pine tree growth declined over the years at the high CO2 levels, he said. The trees bathed in high CO2 also added more fine roots, which Schlesinger suggests is just another indicator of low...JCI table of contents, February 2, 2004
...rg/press/21003.pdf Researchers identify enzyme deficiency underlying sweet-smelling metabolic disease Maple... disease (MSUD) is an inherited disorder caused by deficiency of the enzyme branched-chain alpha-keto acid dehydrogenase involved in amino acid metabolism, and is...Two-drug approach might shorten painful labor, reduce Caesarean sections
... Sherwood said. "It would simply fill a late-term deficiency and would be safe." A regulatory hurdle, however, exists. Relaxin is not approved for use in humans. BAS Medical, a private company in California, recently purchased the rights to recombinant human relaxin. "It remains to be determined if BAS Medical...JCI Table of Contents, January 15 2004
...n of the central nervous system. It is caused by a deficiency of the enzyme hexosaminidase, which results in the....pdf Regulating folate receptors during folate deficiency Folate, a type of B vitamin, is important in DNA synthesis and folate deficiency can lead to fetal ...Study finds huge variability in vitamin E absorption
...n E back," Traber said. There were a number of deficiency diseases in the early 1900s that have been largely eliminated with routine vitamin supplementation of food staples like flour and milk, Traber said. Chronic deficiencies of vitamin D led to rickets, vitamin A to blindness and the B-vitamin niacin to ...Aged roaches experience perils of stiff joints, find Case researchers
...d after the roach's head was removed, suggesting a deficiency in the brain. She noted that the importance of this study is that it stresses the importance of multi-level approaches to the study of age-related changes in behavior and the nervous system. "If we looked at only one study, we would have a skewed vi...Quark Biotech generates a cholesterol-free mouse
...l recessive malformation syndrome resulting from a deficiency of this enzyme named desmosterolosis. Since only two cases have been identified, the desmosterolosis phenotype has yet to be fully delineated. However, it appears that during embriogenesis, rodents benefit from the cholesterol synthesized by mother, ...JCI table of contents, December 15 2003
... forms of cancer, such as leukemia or other immune deficiency diseases. However, there is a risk that transplanted cells may recognize the recipient patient's tissues as foreign and begin to attack them. This reaction, known as graft-versus-host disease (GVHD), can be lethal if it continues unchecked. In the De...People with undetermined muscle/bone pain tend to be severely vitamin D deficient
...aught is medical school. We would expect vitamin D deficiency in old persons or housebound persons," says Greg P...archer on the study. "We found the worst vitamin D deficiency in young persons--especially women of childbearing age. We were stunned to find no vitamin D at all ...A new hope for heavy metal contaminated soils
... healthier or more nutritious crops. Iron and zinc deficiency are two of the most common nutritional deficiencies. The knowledge of the molecular factors governing plant metal tolerance and accumulation could be instrumental in optimising metal contents in plant-derived foods by increasing essential metal conte...Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
...ed in 1978, at the same time AIDS (acquired immune deficiency syndrome) appeared. The survival advantage this genetic mutation provided against smallpox has thus been transferred to AIDS, the authors noted. Following a 1998 paper that linked the gene deletion with bubonic plague, "bubonic plague had been cited ...