Investigational cancer drug prevents abnormal brain growth, reverses seizures in lab mice
...ders caused by Pten deficiency," Baker said. "Pten deficiency in the brain can cause disorders as varied as Lhermitte-Duclos disease, ataxia, seizures and glioblastoma multiforme." Lhermitte-Duclos disease is caused by hypertrophy (enlargement) of the granule cells in the cerebellum, which results in headaches,...Enzyme revealed that is key to fungus's ability to breach immune system
...ide in laboratory cultures. Fungus with the enzyme deficiency also ceased to grow when in the presence of nitric oxide, whereas ordinary fungus survived normally. Mice infected with the flavohemoglobin-deficient C. neoformans survived for five days longer than those infected with the normally virulent strain. ...Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
...agues suggest that colorectal tumors with the MED1 deficiency may resist treatment not only with alkylating agents but also with other drugs used against colorectal cancer, such as irinotecan. The research used cell cultures of mouse cell lines, including mice in which the Med1 gene has been inactivated. "Clin...JCI Table of Contents, November 3, 2003
...ciated with Ang IIaccelerated atherosclerosis. OPN deficiency does not however appear to affect slower-progressing atherosclerosis in non-Ang IIinfused ApoE-/- mice where hypocholesterolemia is the man trigger of the atherosclerotic process. Atherosclerosis-associated inflammation of the arterial wall also appe...U-M scientists find genetic 'fountain of youth' for adult stem cells
...s after birth, they found that the effect of Bmi-1 deficiency on stem cells increased over time. By the time they were one-month-old, it was difficult to detech any neural stem cells in either the central or peripheral nervous systems of the Bmi-1-deficient mice. "This failure of neural stem cells to persist i...Gene mutation responsible for Chrohn's disease inflammation identified in Temple study
...n. In a previous study, Colman demonstrated that a deficiency in this protein led to a much milder form of inflammation. "Finding this mutation is important because we are now in a position to look for the same genetic mutations in humans, the presence of which would confirm that the protein kininogen plays a...Childhood brain tumors associated with rarely inherited BRCA2 gene mutations
... rare inherited disorder characterized by a severe deficiency of red blood cells, bone marrow failure, and a predisposition to cancer. The registry was established at The Rockefeller University in 1982 to address questions relating to diagnosis, prognosis, treatment, natural history of the disease, and cancer i...NIH told regular and moderate exposure to sunlight is the key to preventing chronic disease
...ring this epidemic are profound. Today, Vitamin D deficiency is associated with more than 100,000 additional cases of cancer and 30,000 annual cancer deaths. The epidemic extends beyond cancer to Type I diabetes, heart disease and other chronic adult disease. Possible overexposure to ultraviolet light should...JCI Table of Contents, 1 October, 2003
...ses morbidity and mortality due to infection. This deficiency is most pronounced in the delayed reconstitution of CD4+ T cells and the rate of reconstitution is slower in older recipients. A challenge for researchers has been the determination of a post-transplant strategy to boost T cell reconstitution that wo...Genes discovered that regulate blood stem cell development
...dx4 gene, which is associated with the early blood deficiency as well as abnormal developmental patterning, incl... overexpression of these genes can reverse a fatal deficiency in these blood cells. "These zebrafish findings will allow us to better understand normal blood dev...Drug developed for rare disease may help millions more as treatment for cancer, autoimmune diseases
...ibrotic diseases. In much the same way that copper deficiency inhibits the angiogenic effect in tumor cells, Bre...ies to date show the primary side effect is copper deficiency from overtreating. This causes anemia, but is corrected by lowering the dose or stopping the TM trea...ITA to AMA: Taxing tanning sends wrong health message to teens
...acture Vitamin D. We now understand that vitamin D deficiency is epidemic in American society and that this essential nutrient plays a major role in controlling abnormal cell growth. According to the nation's leading expert in the field, Dr. Michael F. Holick, a professor of medicine, dermatology, physiology an...Fishing for photos of rare or unknown deep-sea creatures with an electronic jellyfish lure
...eir own light, or bioluminescence. This scientific deficiency stems from not only a lack of exploration and study of the oceans, but also from less than ideal traditional research methods. Deep-towed nets can shred animals like jellyfish or damage captured animals to the point that their natural behaviors canno...Few Filipino farmers know of the benefits of golden rice
...what a transgenic crop is," says Chong. Vitamin A deficiency is a public health problem in over 100 countries, according to the World Health Organization (WHO). It is particularly acute in Africa and Southeast Asia, where it is the leading cause of preventable blindness in children. Today there are more than 1...JCI Table of Contents, 15 August 2003
... Diabetes is caused by an absolute or relative deficiency of insulin-producing b cells.In order to elucidate...bserved in human type 2 diabetes. TITLE: Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass AUTHOR CONTACT: Michael Ristow F...Researchers identify new cause of genomic instability
...rs appearing beyond what would be seen with H2AX deficiency alone, and far, far beyond p53 deficiency alone," said Alt. These cancers developed so rapidly that within a few months all the mice had died,...Mutation may help cause acute myeloid leukemia
...ood cells. It can lead to severe anemia and immune deficiency and often is fatal. Although AML accounts for less than 3 percent of all cancers, it is the leading cause of cancer death among Americans under age 35. It also strikes older people, in whom it can be difficult to treat. About 12 percent of AML patie...JCI table of contents, July 15, 2003
...-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBb AUTHOR CONTACT: Robert S. Garofalo Pfizer Global Research and Development, Groton, Connecticut, USA. Phone: 860-441-1055 Fax: 860-441-0548 Email: robert_s_garofalo@groton.pfizer.com View the PDF of this article at: https...Obese mice provide clues to a natural system that puts brakes on obesity
... know that obese patients actually have a relative deficiency of growth hormone," Stoffel says. "And, we can't give growth hormone to patients because there are too many negative side effects."......rome type 4 with a B lymphocyteintrinsic selective deficiency in Ig class-switch recombination AUTHOR CONTACT: Anne Durandy ISERM, Hpital Necker-Enfants Malades, Paris, France. Phone: 33-1-44-49-50-89 Fax: 33-1-42-73-06-40 Email: durandy@necker.fr View the PDF of this article at: https://www.the-jci.org/pres...