Seeking the cause of a mysterious whale disease
...85. The list of possibilities ranges from nutrient deficiency and environmental toxins to genetic mutations and infection. From just January to March of this year there were 20 dwarf and pygmy sperm whale strandings in the southeast. Typically there are only about 12 in the region in an entire year. NMFS is ...U-Iowa physician suggests possible enzyme deficiency in cystic fibrosis
...nts with cystic fibrosis (CF) may be linked to the deficiency of an enzyme called arylsulfatase B. The deficiency may in turn be linked to the known genetic mutation in CF -- a defect in the cystic fibrosis transme...Development of prostate drug based on UT Southwestern research
...en with a rare genetic disorder 5-alpha reductase deficiency - did not develop normal prostates or prostatic enlargement. He theorized at the time that reproducing this condition artificially may lead to nonsurgical treatment of an enlarged prostate. He later identified the genes that encode for 5-alpha reduct...JCI table of contents, 16 June 2003
...****************************************** Enzyme deficiency tips balance towards mutated DNA TITLE: Site-spec...mutations in patients with thymidine phosphorylase deficiency AUTHOR CONTACT: Michio Hirano Columbia University College of Physicians and Surgeons, New York, New ...Prematurity, infections most likely causes of brain damage among infants
...ractice cases try to relate brain damage to oxygen deficiency during the birthing process," says lead author Cyn... gynecology and obstetrics. "In our study, oxygen deficiency played a very small role in the neurologic injuries seen in these infants. Even with the increase i...JCI table of contents, 2 June, 2003
...https://www.the-jci.org/press/17220.pdf Enzyme deficiency produces skinny mice TITLE: Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1 AUTHOR CONTACT: Robert V. Farese Jr. Gladstone Institute of Cardiovascula...With government nod, gene therapy pioneered at UNC is given to children with rare disorder
...e have a mutation in one of their genes, causing a deficiency of an enzyme responsible for removing cellular waste," said Dr. R. Jude Samulski, professor of pharmacology at UNC's School of Medicine and director of the Gene Therapy Center. "In this disease, waste product builds up, causing brain cells to die." A...Equine cloning may shed light on human cancer causes
...uppressor of intracellular calcium and believe its deficiency is the root cause of abnormally high intracellular calcium." Woods established the Northwest Equine Reproduction Laboratory on the UI campus in 1986. He had come full circle, having completed pre-veterinary courses at the UI in 1974. A few years late...JCI table of contents, May 15, 2003
...ion of pulmonary hypertension. TITLE: Heterozygous deficiency of hypoxia-inducible factor-2a protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia AUTHOR CONTACT: Peter Carmeliet KU Leuven, Flanders Interuniversity Institute of Biotechnology, Leuven, Belgium. Ph...Gene enhances prefrontal function at a price
...redicted that the drug would, in effect, correct a deficiency in people with val/val that they would experience more optimal levels of dopamine and perform better on working memory and other cognitive tasks known to depend on the prefrontal cortex. They further predicted that people with met/met on amphetamin...Bleeding disorder tied to defect in cellular transport mechanism
...e. (MCFD2 is short for multiple coagulation factor deficiency 2.) The team identified seven distinct mutations in the MCFD2 gene which appeared in nine of the 12 families studied. The researchers propose that these two proteins, LMAN1 and MCFD2, bind together to form a transporter which is specifically tailore...March of Dimes awards $250,000 prize to pioneers in genetic research
...our understanding of the consequences of vitamin A deficiency during prenatal development and childhood. A major discovery by Prof. Chambon was the finding in mice that the retinoids exert control over embryonic development by acting on homeogenes, those vital genes at the top of the hierarchy of gene regulati...Novel gene therapy on the horizon, says Brenner Children's Hospital pediatrician
...th Syndrome (SIDS) and Trifunctional Protein (TFP) deficiency in infants and their mothers. "The treatment involves getting the right protein into the cells or mitochondria they need to function properly," Payne said. "Mitochondria produce most of the energy within cells and defects in their function are amon...What makes the body absorb too much iron?
... expected to behave like healthy mice with an iron deficiency they ought to produce more iron-absorbing proteins in the intestine. That wasn't the case. So the researchers started to look farther afield for other effects of mutant Hfe. They discovered something intriguing in the liver. A molecule called hepcid...News tips: Genetics research builds on legacy of double helix
...herapy may be an effective means of correcting the deficiency and stimulating new blood vessel formation." In cancers, for which new blood vessels fuel tumor growth, Semenza says efforts are ongoing at academic institutions and pharmaceutical companies worldwide to develop drugs against HIF-1 that may ...Virginia Tech inventions, creations can improve lives
...l formation of blood clots to stop bleeding. It's deficiency results in hemophilia B. The researchers use genetically engineered pigs as bioreactors that make human Factor IX in their milk. Methods of separating Factor IX from the milk and methods of treating hemophilia B are also described by the patent. The ...Link made between dietary folate, genetic instability and bladder cancer risk
...developing bladder cancer," he added. Folic acid deficiency is one of the most common nutritional deficiencies...ior to the fortification of foods with folate, the deficiency was estimated to affect 10 percent of the U.S. population. Folate itself is crucial to DNA synthesi...As harmful as osteoporosis but less well known - New research better explains sarcopenia
...ulation. Furthermore, in transgenic mice, an IGF-I deficiency caused by IL-6-related mechanisms determined growth impairment. A New Study In light of such evidence, a potential effect of IL-6 and IGF-I in the regulation of the homeostatic mechanisms that maintain an adequate muscle mass can be claimed. One hyp...UC Riverside biochemists develop technology to increase Vitamin C in plants
... to prevent diseases arising from severe vitamin C deficiency such as scurvy. This amount can be obtained through a balanced diet that emphasizes fresh green leafy vegetables and citrus. However, these foods are often not sufficiently represented in the diet and up to 30% of the population fail to achieve the...The timing of hormone replacement therapy could be key to success
...s administered to monkeys at the onset of estrogen deficiency which compares to the postmenopausal transition in women there was a 70 percent inhibition of fatty build-up in the heart's arteries. In contrast, when estrogen replacement was delayed for a period comparable to six years in women, there was no be...