Tag: "deficiency" at biology news
Mouse model of alopecia
...ollicles, Dr. Coulombe and colleagues found that a deficiency
in just one keratin 17 causes temporary baldness in mice. Dr. Coulombe and colleagues generated keratin 17 (K17)-deficient mice, or K17 knockout mice, in order to define the function of the keratin 17 protein. They found that K17 knockout mice app...
Vitamin C transporter gene discovery in mice
...eficiencies in vitamin C in the mother that is, a deficiency
not significant enough to cause scurvy and the problems that can occur when the fetus prepares to leave the womb. We dont know for sure. What Im suggesting is that the work in mice points to an area that needs to be investigated. In the study, scie...
Scientists discover gene in human egg that may be necessary for female fertility
...that a similar human Mater mutation or its protein deficiency
may cause infertility in some women." The researc... the two-cell stage. If they discover that such a deficiency
exists, it is possible that researchers may one day be able to induce pregnancy by injecting human M...
New study finds need for improved nutrition for low-income African American females
...ican-American children are at higher risk for iron deficiency
than are children from middle- or high-income fami...ion, interference in cellular metabolism, and iron deficiency
anemia. When there is a net negative iron balance, iron deficiency
occurs. The Study A recent stu...
Monsanto to share technologies with Danforth Center to support global cassava research
...rice, which is being developed to combat vitamin A deficiency
in developing countries. Other sharing projects include providing access to a working draft of the rice genome and participating in work to develop virus-resistant sweet potatoes in Africa and papayas in South East Asia....
Scientists combine therapeutic cloning, embryonic stem cells, and gene defect in mice
...isolated and the genetic defect causing the immune deficiency
was corrected by gene therapy. These corrected em...l some day for treating human patients with immune deficiency
(ie. "bubble boy disease") or be applied to a host of other genetic diseases that can be corrected b...
Insulin in heart development
...ly all tissues, it is not surprising that systemic deficiency
in the insulin receptor (IR) leads to the early postnatal death of IR?/? mice. However, Cre/lox technology has also allowed for the creation of animals lacking the IR specifically in particular cell types, and the more subtle phenotypes in these des...
The body's production of melatonin may be the reason why the elderly can't get a good night's sleep
... problem. Too often they are told that a melatonin deficiency
is the cause of their distress. Melatonin is a pu...lenges the marketers notions that the problem is a deficiency
of the hormone itself. Background One of the most prominent changes in sleep that accompanies aging ...
Adhesive interactions in contact dermatitis
...s evident because patients with leukocyte adhesion deficiency
type I (LAD I), who carry mutations in the corresponding human gene, are prone to bacterial infection. Grabbe et al. now report that in a mouse knockout model lacking CD18 entirely, animals are unable to mount the usual inflammatory responses to alle...
Iron supplements help African children learn to walk and talk
...f iron and early child development in Africa. Iron deficiency
anemia is associated with developmental delays that lead to poor performance on scales of mental and motor development among infants and toddlers, as well as on tests of intelligence and cognitive function among preschool and school-age children. The...
Oral administration of estrogen replacement therapy suppresses the biological actions of growth hormones in GH-deficient women
...jects participated in both studies. Growth hormone deficiency
was confirmed by a peak GH response of Study Desi... estrogen aggravates metabolic abnormalities of GH deficiency
and attenuates the metabolic effects of GH therapy. Thus oral estrogen may worsen the body compositi...
New study from Mayo Clinic provides insight into male infertility
...ome development, future screening for this protein deficiency
may help eliminate that as a specific cause of infertility. "The findings will not lead to immediate therapeutic advances in fertility treatment," says Dr. van Deursen. "However, the findings provide valuable insight into the molecular basis of...
Researchers discover new family of naturally occurring antibiotics
...produce antibiotics, then if there is some kind of deficiency
in them, that could be an important contributor to certain types of diseases," Noga said. "On the other hand, if human mast cells make these antibiotics, if they were isolated they could be useful therapeutics for treating any number of diseases." Th...
How genetics can influence learning
...abolizing enzyme ALDH2, which has been linked to a deficiency
in the low KmALDH2 isoenzyme, which can result in stronger physiological responses to alcohol. "A significant percentage of these individuals experience a stronger response to alcohol than people without the gene do," said Gregory T. Smith, associate...
Austrian scientists identify gene involved in recurrent miscarriages
...cles behave. Given also the role that nitric oxide deficiency
plays in high blood pressure, haemorrhage, vascular spasms and infarction, it's reasonable to speculate that carriers of an NOS3 polymorphism are at increased risk for impaired placental function. Displaying this polymorphism is not necessary or suff...
Exploding eggs and rare human disorder help explain water regulation
...nal blood banks and identified six families with a deficiency
in aquaporin-1(AQP1). After tracking down two of t...omb," says King. "If a person suddenly developed a deficiency
in AQP1 without these compensatory mechanisms, they are much more likely to have severe health probl...
Untangling the matrix of risk factors for alcoholism
...veractive transporter gene which could result in a deficiency
of serotonergic synaptic functioning. This is another strong piece of evidence in this evolving story. However," he added, "there remain gaps in our knowledge. We continue to be in a state much like what Newton described when he said 'we are findi...
Study finds nonviral gene therapy for severe hemophilia a is safe with early signs of benefit
... involved six patients with severe hemophilia A, a deficiency
of the blood clotting protein called factor VIII. Each patient was treated with his own cells after the cells were genetically modified in a laboratory to express factor VIII. While the study was conducted to determine whether the treatment was safe,...
Genetic deficiency may explain sudden infant death syndrome
...odel for human mitochondrial trifunctional protein deficiency
and that it has important implications for human disease," Ibdah said. "Many of the associations that were questioned in humans are confirmed clearly in this knockout." He said the study demonstrates that the enzyme is essential for fetal devel...
UF researchers reverse metabolic disorder in mice
..., which stands for phenylketonuria, results from a deficiency
or complete absence of a specific enzyme that is necessary to convert the amino acid phenylalanine - found in all types of protein - into another amino acid, tyrosine. A buildup of phenylalanine is toxic to the central nervous system, particularly th...
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