Tag: "degeneration" at biology news

Calorie Restriction Reduces Age-Related Muscle Loss

... medicine RichardWeindruch. "Age-associated muscle degeneration is seen in mostmammals, including humans." The new findings add to a growing body of evidence supportingsignificant age-retarding effects of a restricted yet nutritious diet. Inaddition to extending life span in many animals, calorie restriction (CR...

Scientists Find New Trigger For Nerve Cell Death

...ide a new therapeutic strategyfor slowing neuronal degeneration in Alzheimer's disease," Choi says....

Scientists Use IGF-I To Grow New Membranes Around Neurons

...ptoms of these diseases are caused by the death or degeneration of peripheral nerves. Although several growth factors are currently under study, IGF-I appears to be most effective at inducing myelination and preventing neural cell death, according to Cheng. Named for its structural similarity to insulin and its...

Increased Amount Of Enzyme In Brain May Be Marker Of Alzheimer's Disease

... into the compact plaques associated withthe nerve degeneration and dementia of Alzheimer's disease. Mesulam is the Ruth and Evelyn Dunbar Professor of Psychiatry andBehavioral Science, a professor of neurology and the director of the behavioraland cognitive neurology and Alzheimer's disease program at N...

Biologists Map First Gene For Age-Related Hearing Loss In Mice

...n abnormal form of theprotein myosin, which causes degeneration of the hair cells inthe cochlea and the vestibular canals the part of the innerear responsible for balance. Erway said the Ahl cannot be identical to the shaker orwaltzer genes, because Ahl only causes hearing loss, not abalance disorder. However, ...

Dog Blindness Gene May Help Humans

...enetic defect responsible for progressive rod-cone degeneration (called prcd), aform of progressive retinal atroph...to treat retinitis pigmentosa (as well as rod-cone degeneration indogs) by cloning the normal gene, inserting a copy into a transfer vector such as a harmless virus...

Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease

...ited neurological disorder characterized by spongy degeneration of the brain. It primarily affects children of Eastern European or Ashkenazi Jewish background. It is one of a group of genetic disorders called leukodystrophies that affect the growth of the myelin sheath of the nerve fibers in the brain. The myelin...

Inhibitor Shows Potential To Protect Infant Brain

...or after birth is the largest contributor to brain degeneration in children. Life-time consequences include mental retardation, seizures and cerebral palsy, which affects 500,000 Americans. Holtzman mimics the condition by interrupting the blood supply to one side of a newborn rat's brain and briefly lowering th...

New Retinal Surgery May Reverse Legal Blindness

...ousands of peoplethreatened by age-related macular degeneration (AMD), the major cause ofblindness in people over 55 years. The technique, called macular translocation, is used in cases of AMD inwhich abnormal blood vessels grow and bleed underneath the retina, according toEugene de Juan, M.D., professor...

Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimer's Disease

...ysfunctionoccurred well in advance of the cellular degeneration considered by manyresearchers to be the cause of Alzheimer's disease. Cell death, when it didoccur, was most evident in the hippocampus, the brain's "storage bin" forshort-term memory, said William L. Klein, senior author on this study. Klein isa pro...

Scientists Identify Key Protein Involved In Progressive Blindness

...renwith Usher syndrome develop progressive retinal degeneration and arefunctionally blind by age 40. They also are born with varying degrees ofhearing loss. In an article published in the June 12 issue of Science, researchers from theUniversity of Nebraska Medical Center, who directed the research project,report...

UF Discovery Of Chicken Gene Mutation Aids Study Of Rare Inherited Eye Disease

...chers also are presentingtheir work at the retinal degeneration symposium. Bill Hauswirth, theRybaczki-Bullard eminent scholar of ophthalmology and molecular geneticsand microbiology, and Al Lewin, a professor in the department of moleculargenetics and microbiology, will present information on AAV gene therapiesf...

Genetic Clue Found To The Leading Cause Of Blindness In The United States

...analysis" to zeroin on the location of the macular degeneration gene. The technique involvescomparing short segmen...chromosome 1 that causes ajuvenile form of macular degeneration and also may be associated withage-related macular degeneration. But this is the first published res...

Penn Researchers Prove "Short-Cut" Function Of Myelin Sheath Channel: BetterUnderstanding Of Myelin Should Lead To Therapies For Neuropathies

...CMTX), a genetic disorder thatproduces progressive degeneration of peripheral nerves. One out of 3,000 peoplesuffer from Charcot-Marie-Tooth disease, with 10 to 20 percent of those havingthis particular inherited form. This led the research team to reappraise thefunction of connexin32 in myelinating cells. They h...

Scientists Find New Clues About Fatal Childhood Disease, Ataxia Telangiectasia

...ionizing radiation, such asX-rays, and progressive degeneration in the brain's cerebellum, which leads toataxia, or weakened muscular control. Other problems include a greatlyincreased risk of cancer, especially leukemia and lymphoma; an unusually highrisk of diabetes and lung infections; and telangiectasia, or ...

Gene Therapy Animal Study Offers Hope For Some Neurodegenerative Diseases

...oduction of a faultygene product that leads to the degeneration of light-sensitive rod cells in theeye. The degeneration occurs in association with autosomal dominant retinitispigmentosa, an untreatable condition of progr...

Proteins Deep Inside The Nucleus Hold Clues For Two Diseases

...MN leads tothis disease, which is characterized by degeneration of motor nerve cells in the spinal cord. SMN (survival of motor neurons) interactswith one type of hnRNP. Essentially, these two proteins must work in concert sothat motor neurons can function properly. When SMN is mutated the capacity ofthe cell to...

Mouse Model For Huntington's Disease Developed By NIH, Vanderbilt

...sorder that results from thegenetically programmed degeneration of cells in certain areas of the brain.Symptoms, w...xpressed -- and the behavioral abnormality and the degeneration found in thebrains of these animals." Researchers hope to learn more about how the abnormali...

Molecular Basis Of Leading Genetic Cause Of Infant Death Discovered

...h. This neuromuscular disease,characterized by the degeneration of motor nerve cells that control the body'sinvoluntary muscles from the head down, originates from defects in the Survivalof Motor Neuron (SMN) gene on chromosome 5. Spinal muscle atrophy is aninherited condition that affects about one in 6,000. ...

New Insight Into Genetic Cause Of Infant Mortality

... and how does decreased SMN protein activity cause degeneration of motor neurons? The team showed that the SMN protein is needed by all cells to produce messenger RNA (mRNA). Production of mRNA is a critical step in gene expression, and ultimately, in the production of functional proteins. Furthermore, motor neu...

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