Tag: "degeneration" at biology news
Columbia Researchers Synthesize Compound With Possible Link To MacularDegeneration; Work Is Critical To Pinpointing Causes Of Disease, Scientists Say
...al hypotheses describing the roleof A2E in macular degeneration
and is proceeding with experiments to refinetheir ... everyday tasks. With theonset of AMD, there is a degeneration
of the retina's rods and cones, cells thatdetect light. One type of AMD, called the "dry" form, aff...
Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
...h paper, "Identification of themouse neuromuscular degeneration
gene and mapping of a second site suppressorallele...ioncauses severe muscle atrophy due to progressive degeneration
of spinal motorneurons, which control the movement of voluntary muscles. The mice exhibitprogressive...
Researchers Find Fas Ligand Is Important In Blinding Disease
... Medicine, the investigatorslink a form of macular degeneration
to potential problems involving theinteraction bet...he findings could mean thatthe wet form of macular degeneration
develops only in people with abnormal FasLthat cannot destroy Fas-positive vascular cells invading t...
Dietary Carotenoid Lutein Reduces Atherosclerotic Lesion Formation In Mice
...a role in reducing the risk of age-related macular degeneration
(ARMD). A 1996 study by researchers at Cambridge University compared the levels ofcarotenoids in blood from people in Toulouse, France, and in Belfast, Ireland. They found that the level of lutein and other oxygenated carotenoids was higherin Toulou...
Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
...a role in reducing the risk of age-related macular degeneration
Study Ensures Effective Ways To Measure Macular Pigment Density
...y, thought to be protective in age-related macular degeneration
(AMD). "Results confirmed and expanded upon what...a role in reducing the risk of age-related macular degeneration
(ARMD), the leading cause of blindness in people over age 65 in the United States, but further resea...
Drug stops blinding blood vessel growth in mice
...eople at risk for blindnessassociated with macular degeneration
or diabetes may one day be able to pop apill to prevent blinding blood vessel growth. Vessels that grow abnormally inthe eyes can leak fluid or blood, causing rapid and severe vision loss. Suchgrowth is the hallmark of diabetic retinopathy and age-...
Gladstone/UCSF team discovers interaction of two brain proteins may be key factor in development of Alzheimer's disease
...lopment of better treatments toprevent or slow the degeneration
of nerve cells that causes memory loss ordisturbed... addition, they found that amyloid proteinsinduced degeneration
of synaptic connections and impeded the ability of neuronsto transmit nerve impulses. These abnormal...
New enzyme tied to tangles in Alzheimer's disease
...ethal to nerve cells and are important in neuronal degeneration
inAlzheimer's," says co-author Peter Davies PhD, Resnick Professor of Alzheimer'sDisease Research at Albert Einstein College of Medicine in New York. "Pin1 isthe first molecule known to change the shape of tau." According to the new study, Pi...
Mice show function of gene that causes two types of blindness
...20,000 children over age 6, andage-related macular degeneration
(AMD) develops in approximately one in fouradults over 65. Both disorders affect central vision, which enables reading,driving and face recognition. The work is a major step toward finding treatmentfor these macular-degenerative illnesses, in which c...
Damaged spinal cord found to have greater potential for nerve regrowth than thought possible
...o the white matter pathways in our study, all that degeneration
andinflammation, would produce a nerve fiber pathway potently inhibitory for nerve growth," he said. "But we saw scads of axons,"said Silver. "Amazingly, after a full three months, there is still potential for regeneration away from the injury." When...
Gene therapy holds promise for treating inherited Lou Gehrig's Disease
...s a protein that has been found to block nervecell degeneration
in animal models of Parkinson's disease. The GDNF gene therapy enhanced survival of motor neurons in thelaboratory model of inherited ALS and increased the number of motor neurons thatmaintained 'communication' with cells in treated leg muscl...
Is your diet making you lose more than weight?
...re many other factors involvedin the formation and degeneration
of bone mineral density. The women who increased their physical activity to a "high" level(defined as more than 4180 kJ/wk) had significantly less bone loss than women who had "low" levels of physical activity.This study provides strong evidence that...
Gene protects tubby mouse strain from hearing loss
...oblems at three weeks of age, experiencingcochlear degeneration
due to progressive loss of hair cells and neurons. Normalhearing results when sound waves cause the tiny hairs to oscillate, with themovement transmitted as electrical impulses through the hair cells to the brain.Hearing ability in mice is measured w...
New machine may provide answers about leading cause of blindness
...between levels of macular pigment and macular degeneration
in specific situations. These correlations havebeen documented with factors such as eye color, gender and smoking. Other studies have found associationsbetween dietary intake or blood concentrations of cartenoids (a nutrient found in spinac...
Effects of Muscular Dystrophy reversed by gene therapy, reports team fromChildren's National Medical Center and the University of Pittsburgh
...thousand people in the UnitedStates, causing rapid degeneration
of the large muscles attached to theshoulders and hips. Currently no effective treatment exists for this fataldisorder. The Children's/Pitt team of investigators is currently planning agene therapy treatment protocol based on the experimental findi...
Harvard and Alexion researchers report successful transplantation of immuneprotected neurons in primate model of Parkinson's disease
...ty and tremor.Parkinson's disease is caused by the degeneration
of the dopamine-producingneurons in the substantia nigra of the brain, resulting in decreased dopamineavailability. In the study, these scientists demonstrated that transplantation of neurons fromAlexion's transgenic pigs restored dopamine production...
Purdue researcher finds genetic link to calcium regulation in cells
...alled inaF, also appear to suppress the effects of degeneration
caused by the overactivity of some calcium channel...e degeneration. Their study suggests that this degeneration
was caused by overactive TRP channels, which allowed calcium ions to accumulate in the cells, thus k...
New transgenic mouse likely to advance Alzheimer's disease research
... player as beta amyloid in the mechanisms of brain degeneration
associated with Alzheimer's disease," says John Q. Trojanowski, MD, PhD, a coauthor on the study, codirector with Lee of the Center for Neurodegenerative Disease Research, and a professor of pathology and laboratory medicine. "Some of us, however, ha...
Playing the odds: Can you stop abusing alcohol at 10 years and be OK?
...be answered is how much of a risk, and how quickly degeneration
will commenceonce alcohol abuse begins. Despite what vulnerabilities to alcohol dependency and/or brain damage may exist, Sullivan's work hasdemonstrated that alcoholic brains can recover to various degrees once drinking has ceased. "One thing that's...
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