Tag: "degeneration" at biology news

Trial drugs for Huntingtons disease inconclusive in slowing disease

...e defective gene from one of their parents develop degeneration of specific brain regions. Symptoms usually begin in early to mid-adulthood, but children are occasionally affected. Signs of the illness include involuntary movements called chorea, as well as motor and cognitive difficulties. It is a progressive ...

Vaccination following spinal cord injury: Innovative Weizmann Institute approach limits paralysis

...related but different therapeutic target: to limit degeneration after a partial spinal cord injury. The scientists...s that survived the initial trauma. This secondary degeneration can be even more destructive than the initial damage. As a result, an injury that initially inflicte...

Gene therapy may be a tool to prevent blindness

...ssels in the eye that blinds patients with macular degeneration and diabetic retinopathy, according to two recent ...vival. The mice had conditions similar to macular degeneration and diabetic retinopathy, the leading causes of blindness in older and younger people, respectively,...

Spinach protein could offer new hope for the blind

...he eye. People who suffer from age-related macular degeneration or retinitis pigmentosa, diseases that are leading...s protein to a retinal cell. In the United States, degeneration of the retina has left 20,000 people blind and 500,000 people visually impaired. Retinitis pigmentos...

USF Alzheimer's vaccine research boosted by $1.1-million NIH grant

...as transgenic mice) that produce age-related brain degeneration much like Alzheimer's disease. The study, published in the journal Nature, attracted international attention. The new grant includes an outside scientist, internationally-recognized for vaccine development, who supplements Dr. Ugen's background in t...

Researchers find gene for rare disorder that paralyzes children's legs

...Lou Gehrig's disease) all experience a progressive degeneration of certain nerve fibers in their spinal cords. Th...s. Disturbance in this process could lead to nerve degeneration and symptoms of spastic paraplegia. If further research can uncover more about whether and how the m...

Clues to development of eye's light-sensitive cells found

Study has implications for understanding macular degeneration and retinitis pigmentosa ANN ARBOR, MI - A pape...can then be tested for mutations linked to macular degeneration and cone dystrophies."...

Comprehensive set of vision genes discovered: Identification could help in diagnosing and treating blinding diseases

...diagnosing and treating blinding diseases. Macular degeneration alone affects twenty-five percent of people over age 75. The discovery of the full set of photoreceptor genes expressed in the retinal cells, which was made in mice, could also lead to new methods for preserving and restoring the vision of those affe...

Protein protects against degeneration of neurons in fruit flies

... produce a human protein that protects against the degeneration of neurons similar to those affected in Parkinsons disease. The protective protein, called a chaperone, suppresses the toxicity of a -synuclein, a protein associated with Parkinsons disease in humans. Progressive loss of dopaminergic neurons produce...

Penn team finds 'molecular chaperones' can halt progress of Parkinson's disease in fruit flies and possibly humans

...sensitivity to alpha-synuclein, with marked neural degeneration at just one day of age. Both Hsp70 and Hsc4 are thought to function by untangling misfolded proteins, mitigating the harmful effects of inappropriately configured proteins. "These studies emphasize the sensitivity of dopaminergic neurons to chapero...

Nature's own medicine for vision loss: Inhibitor of angiogenesis found by biologists at The Scripps Research Institute

...l angiogenesis is the cause of age-related macular degeneration (ARMD) and diabetic retinopathy, diseases that afflict tens of millions of Americans and cause catastrophic vision loss in many. Both of these eye diseases are characterized by the development of abnormal blood vessel growth in the eye. In the case o...

Worm neuron research may lead to powerful model for Parkinson's study

...l for studying the molecular mechanisms underlying degeneration of dopamine neurons in the brains of patients with Parkinsons disease (PD). The paper, co-authored by Nass, a post-doctoral research fellow in Pharmacology; Randy D. Blakely, Ph.D., Alan D. Bass Professor of Pharmacology; and David M. Miller, III,...

Undergrad probes regeneration of nerve cell branches

...cal treatments for optic disorders involving nerve degeneration or injury, or for spinal cord injuries....

New x-ray technique images cartilage, may lead to earlier diagnosis of osteoarthritis

...fill the x-ray imaging void in detecting cartilage degeneration earlier. The DEI images taken used synchrotron r...ays, if a person is losing their cartilage through degeneration by watching the spaces between their bones get smaller as the cartilage wears down, Muehleman says. ...

Researchers discover new mechanism that targets and destroys abnormal RNA

...the net result was simply to be wasteful, to cause degeneration of transcripts, then we would expect that they would not be conserved. But the fact that they were conserved suggests that these nonstop transcripts, and the proteins that could result from them, may have some importance in normal development. Accord...

Lowly cytokine may play role in controlling neurotransmitters

... host of illnesses are caused by a degeneration of neurons....

New evidence on revolutionary brain pacemaker for Parkinson's Disease patients

...kinsons is unknown, but the symptoms stem from the degeneration of neurons (brain cells) that produce dopamine. Dopamine is a neurotransmitter that enables communication among the brain cells involved in motor control. Activa Therapys electrical stimulation acts on these malfunctioning circuits in the brain usi...

Study identifies new protein on neurons that may be useful as survival/growth factor

...f these older, CD40-deficient mice showed signs of degeneration and the mice demonstrated gross central nervous system abnormalties with age. "These effects suggest that the CD40 signaling on neurons plays a physiological role in normal neuronal cell maintenance and confers resistance to aging-induced stress," J...

Glaucoma leading cause of blindness in Hispanics

...dness in Hispanics. Cataract, age-related macular degeneration and diabetic retinopathy also were common. Hispan...r 47 percent of all problems. Age-related macular degeneration and diabetic retinopathy accounted for 14 percent and 13 percent of problems, respectively. Open-an...

Study of vision disorder leads to discovery of new family of ion channels

...itary macular dystrophy, we are looking at macular degeneration from another starting point in the disease mechani...xample, ophthalmologists have noticed that macular degeneration seems to start by accumulation of material in the retinal pigment epithelium (RPE), the exact region...

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