Mouse genetic model for spongiform brain diseases
...for mahogany-colored coats also develop spongiform degeneration of brain tissue, similar to mad cow disease. Becau...ry at Stanford. "We do see the same kind of tissue degeneration -- with fluid-filled vacuoles, or holes, where the gray matter should be -- in BSE cattle with bovin...New study of healthy men finds semen quality decreases with age
...ed narrowing and sclerosis of the testicular tube, degeneration of germ cells, and normal changes in the prostate, or to increased probability of exposure to disease or environmental agents. "We considered time worked at Lawrence Livermore and occupational exposure in our study, and found no evidence that they a...Study shows how eye cells die when exposed to lead
...with the low-level lead exposure and slow cellular degeneration that actually occurs in human disease," he says....Fasting forestalls Huntington's disease in mice
...D. The disease results from genetically programmed degeneration of nerve cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss ofintellectual faculties, and emotional disturbance. Specificall...New hope for preventing major problems of the retina
...to these landmarks can lead to age-related macular degeneration and diabetes, the cause of severe visual problems. Dopamine is an intermediate in tyrosine metabolism and precursor of norepinephrine and epinephrine; it accounts for 90 percent of the catecholamines; its presence in the central nervous system and lo...Stem cells contribute to tissue regeneration in mice with ALS
...gressive neurodegenerative disease that causes the degeneration and death of motor neurons required to initiate voluntary muscle activity. With no known cure, ALS patients gradually become totally paralyzed, while most retain complete cognitive function, with an average life expectancy of two to five years after...Drug combination increases life span of mice with ALS
...n approach for treatment of a disease with complex degeneration pathways. The three drugs are currently available and we hope that our study will justify a trial on ALS patients," says Dr. Julien....Genetic risk factor for Parkinson disease discovered
...he brain that controls movement. Progressive nerve degeneration results in difficulty initiating movements such as...e of the mechanisms proposed to be responsible for degeneration of neurons involved in Parkinson's disease is excessive oxidative stress over time," said Vance. "Th...Widespread cannibalism may have caused prehistoric prion disease epidemics, Science study suggests
...iform encephalopathy, or BSE, in cows, cause brain degeneration and, ultimately, death. In a previous study, Collinge and his colleagues determined that people with one normal copy and one mutated copy of the prion protein were somehow protected against Creutzfeld Jacob disease. The mutation consisted of a singl...Adult stem cells shown to develop into all brain cell types
...d nerve cells in regions of the brain that undergo degeneration with Parkinsons disease, multiple sclerosis, Huntingtons disease, ataxia, and Alzheimers disease. This tells us that these adult stem cells are capable of becoming nerve cells that communicate with other nerve cells within the brain and form proper n...Gene discovery may shed light on carpel tunnel syndrome and Lou Gehrig's disease
...dominant fashion. All types of SMA are due to the degeneration of nerve cells within the spinal cord, as opposed to degeneration of the peripheral nerves. Distal spinal muscular atrophy (dSMA) disease is a type of SMA that affect...Ingenium publishes groundbreaking research on genetic basis for motor neuron degeneration
...specific gene mutations and selective, progressive degeneration of motor neurons. The research groups initially be...er cell types. This type of selective motor neuron degeneration is clinically similar on a cellular and organismal level to the human disease state seen in ALS and ...UI researchers discover new cause of muscular dystrophies
...e diseases, the characteristic, progressive muscle degeneration is due to a faulty muscle-repair mechanism rather than an inherent weakness in the muscle's structural integrity. The research findings, which appear in the May 8 issue of Nature, reveal a totally new cellular cause of muscular dystrophy and may lead...Scientists at UCSB link brain plaques in Alzheimers disease to eye disease
...etina that are associated with age-related macular degeneration (AMD). AMD is a disease that leads to loss of cent...of approximately one million nerve fibers. Macular degeneration is a blinding disease caused by the death of the photoreceptor cells in that part of the retina know...Tiny protein prevents disease-related cell death
...es, including Parkinsons, stroke, heart attack and degeneration of ovaries during menopause. These results, to be published later this month in the journal Nature (currently available at the journals website), suggest a novel target for therapeutic design based on inhibiting the cell destructive activity of Bax...Abnormal immune response may play major role in glaucoma, study says
...ur in other blinding eye diseases, such as macular degeneration and retinitis pigmentosa. The research team includes Drs. Simon W. M. John, Richard S. Smith, and Michael Anderson of Jackson Laboratories, and Drs. Jun Song Mo, Bruce R. Ksander, and Meredith Gregory of Schepens Eye Research institute....With government nod, gene therapy pioneered at UNC is given to children with rare disorder
...dren have Canavan disease, characterized by spongy degeneration of the brain's white matter. The disease affects the growth of the fatty myelin sheath insulating nerve fibers. Canavan disease symptoms appear in early infancy and progress rapidly. These may include mental retardation, loss of previously acquired m...Injection prevents blinding blood vessel growth in mice
...ed with diabetic eye diseases and possibly macular degeneration in laboratory mice. By injecting a fused prote... by diabetics. Unlike other treatments for macular degeneration and diabetic retinopathy, which require treatment of one eye at a time, the shot could take care of ...JCI table of contents, July 1 2003
...pharmacological activators may also control vessel degeneration in ROP and other retinopathies. TITLE: Selective s...f VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity AUTHOR CONTACT: Lois E. H. Smith The Children's Hospital, Boston, Ma......pharmacological activators may also control vessel degeneration in ROP and other retinopathies....