Tag: "degeneration" at biology news
OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine
...enerative disease known as wet age-related macular degeneration
(AMD). Between 2 million and 3 million people in ...AMD are diagnosed worldwide. In the U.S., macular degeneration
is the leading cause of severe and irreversible vision loss in people over age 60. While wet AMD re...
Sleep disorders linked to faulty brain chemistry, study finds
... sleep problems; their disease's tendency to cause degeneration
of certain nerve cells in their brains and spinal cords; and clinical evidence that some of their sleep problems can be successfully treated with medications that replace lost dopamine. MSA is a complex, debilitating and life-shortening disease that ...
JCI table of contents, July 15, 2003
...erally protective against the thickening and fatty degeneration
of the interior walls of blood vessels, known as atherosclerosis. This vessel degeneration
is a common cause of morbidity and mortality in chronic renal failure. Reduced NO expression results...
World Congress on Huntington's Disease to meet in Toronto, August 16-19, 2003
...nother 150,000 risk developing this disorder. The degeneration
of brain cells, called neurons, in certain areas of the brain leads to psychiatric, intellectual, and movement problems. Because the disease is inherited in an autosomal dominant fashion, each child of a person with HD has a 50% risk of also developi...
Study shows enzyme helps guard against Alzheimer's disease
...nversely correlates with neuronal vulnerability to degeneration
in normal brains, and with the actual formation of tangles in patients with Alzheimer's," says Lu. "Furthermore, we found that in the Pin1 knockout mouse, the removal of the Pin1 gene alone was sufficient to cause many age-dependent neurodegenerative...
How a little bit of cold can kill a big manatee, and what it might mean for the species
...ocytes, various skin and intestinal lesions, heart degeneration
and pneumonia. Knowledge that the cold can cause even more devastating and extensive effects than previously realized could help managers decide how to deal with the closing and deregulation of aging and under-used power plants. More than 500 mana...
Gene mutation found for eye disease that mimics macular degeneration
...an eye disease that looks like age-related macular degeneration
(AMD), but that has a rarer pattern of inheritance that results in an exceptionally high incidence of the disease among family members in the study. In the August issue of Investigative Ophthalmology & Visual Science (IOVS), Kellogg scientist Radha A...
Gene therapy prolongs survival, slows disease progression in ALS mice
...a fatal neuromuscular disease characterized by the degeneration
of spinal and brainstem motor neurons, leading to atrophy of limb, head-and-neck, and respiratory muscles. Plans for the first ALS patient trial utilizing this approach are underway. Fred H. Gage, Brian Kaspar, and colleagues, injected an adeno-assoc...
Chicken embryo research tunes into inner ear
... loss," she said. "These cases are often caused by degeneration
of inner ear cells damaged over the long term. Many young people also lose their hearing from sudden acoustic trauma. If we are to replace the damaged cells, we will presumably need to know how to grow the right cell type." Another problem this resea...
Study at TSRI links dozens of proteins to several rare muscle and nerve degeneration diseases
...s several of them with rare human muscle and nerve degeneration
diseases. The team is publishing their findings this week in the journal Science. Led by TSRI Professors Larry Gerace and John R. Yates III, the team used a technique called subtractive proteomics to identify 62 new proteins in the inner nuclear mem...
UGA researchers use transgenic trees to help clean up toxic waste site
...tter," which described the process of neurological degeneration
that came from working with the metal. In this part of New England, the symptoms of mercury poisoning were called the "Danbury shakes.") Meagher's lab actually has two genes that can effect phytoremediation, merA and merB, but since the merA is activ...
Stem cells delivered into back of eye hold promise for people with retinitis pigmentosa
...esent in three layers, and in the model of retinal degeneration
the two deeper retinal vessel layers completely de...e mutations have been documented that lead to this degeneration
of the retina, and about one in every 3,500 people suffer from loss of vision caused by retinitis pi...
Two studies find Gulf War veterans have increased risk of ALS
...so known as Lou Gehrig's disease, ALS involves the degeneration
of motor neurons which causes muscles to waste away. Approximately 20,000 Americans have ALS, which is usually fatal within five years after diagnosis. The Department of Veterans Affairs added ALS to the list of service-related disabilities in 2001....
New gene for rare inherited paralysis may aid other spinal cord research, too
...rlaps between this group of diseases and the nerve degeneration
processes in other disorders," says senior author John Fink, M.D., professor of neurology at the University of Michigan Medical School, who has devoted his career to studying and treating HSP and related conditions. "Not only do we hope this discover...
UCSD researchers discover gene able to suppress retrovirus insertion mutations
...rator mice, which have severe tremors, progressive degeneration
of the brain stem and spinal cord, and die early. However, the UCSD team found that vibrator mice carrying the mvb1 genes showed reduced tremor severity and survived to adulthood. The team showed the Mvb1 did this by raising the amount of normal RN...
The genetics of blindness
...re. This disease causes vision loss by progressive degeneration
and death of the cells that make up the retina, the portion of the eye that responds to light. "Retinitis pigmentosa is a devastating and complex disease," says principal investigator, Dr. Robert Koenekoop, director of pediatric ophthalmology at the...
Genes that regulate hearing link humans and fruit flies in new way
...cs of fruit fly optics to learn more about retinal degeneration
and other vision disorders in humans. "We're hop...t hearing disorders in children as well as hearing degeneration
in adults," she said. The current study was an outgrowth of Boekhoff-Falk's earlier research on th...
World's largest scientific society holds regional meeting in Long Beach, Calif.
... neurological diseases, including Parkinson's-like degeneration
of brain cells and behavioral problems such as violence and attention deficit disorders. The effects seen may depend on when an individual was exposed and the route of exposure. The researchers will show how they can differentiate prenatal and postna...
JCI table of contents, 15 October, 2003
...new brain cells and protects existing neurons from degeneration
following injury. The study suggests that FGF-2 su... repair. TITLE: FGF-2 regulates neurogenesis and degeneration
in the dentate gyrus after traumatic brain injury in mice AUTHOR CONTACT: Michael A. Moskowitz Mas...
Gene-expression atlas will provide new direction for brain and spinal-cord studies
... Such studies will enable to dissect mechanisms of degeneration
at a much more precise level in the intact brain."...
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