Daily vitamins could prevent vision loss among thousands
... American at risk for advanced age-related macular degeneration (AMD) took daily supplements of antioxidant vitamins and zinc, more than 300,000 people could avoid AMD-associated vision loss over the next five years, according to results of a new government study led in part by researchers at Johns Hopkins' Wilme...Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
... as brain tissue, where they cause the progressive degeneration of cognitive and motor functions and ultimately prove fatal. Amyloid fibrils form as a result of mistakes in a protein's normal folding process. Each disease involving amyloid fibrils stems from the misfolding of a different protein that then packs ...Purdue researchers create templates on retinal tissues
... treat age-related macular degeneration. Macular degeneration destroys light-sensing cells in the retina. Resear...hydrogen atoms strung together. Macular degeneration is an incurable eye disease that is the leading cause of blindness for people 55 and older in the Un...OXiGENE launches significant expansion of its R&D program in ophthalmology
...er a 35-year-old man suffering from myopic macular degeneration showed dramatic improvement following treatment wi...es and expect to launch a clinical study in myopic degeneration and other diseases complicated by subfoveal choroidal neovascularization. In addition, we will acti...JCI Table of Contents, January 15 2004
...he-jci.org/press/19894.pdf Understanding nerve degeneration in spastic paraplegia Hereditary spastic parapleg...iverse patterns of inheritance, which is caused by degeneration of nerve axons. Elena Rugarli and colleagues from the Telethon Institute of Genetics and Medicine in...JCI table of contents, February 2, 2004
... the diabetes, insulin resistance, and fatty liver degeneration associated with lipodystrophy a disturbance in fat metabolism. This hormone, expressed by fat cells, acts on a variety of tissues including the brain, skeletal muscles, heart, and pancreatic beta cells. In the February 2 issue of the Journal of Clin...New findings are a window into the late stages of 'Lou Gehrig's' disease
...st invariably fatal, disease that is caused by the degeneration of the body's motor neurons, muscle atrophy and weakness. No one knows what causes the process of terminal neurodegernation to begin. However, using a two-step process to analyze 6,800 genes, scientists have now found an ALS-specific "signature" in ...JCI table of contents, 16 February 2004
...into the DCN remained intact and no other signs of degeneration in the cerebellar cortex or elsewhere in the brain were observed, indicating a direct relationship between DCN firing rate, regulation by SK channels, and proper muscle coordination. The report suggests that reestablishing a normal DCN firing rate mi...JCI table of contents, March 1 2004
... heart cells was sufficient to correct the cardiac degeneration associated with the absence of sarcoglycan, and al...extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy AUTHOR CONTACT: Elizabeth McNally University of Chicago, Chi...Search for macular degeneration genes narrows
... to find genes associated with age-related macular degeneration (AMD). In a paper published in the March issue of American Journal of Human Genetics, Kellogg scientist Anand Swaroop, Ph.D., and his team of researchers have confirmed three previously suggested loci (on chromosomes 1, 5, and 9) for potential AMD ge...MGH study finds female mammals produce egg cells into adulthood
...r corpses." "Finding such a high level of follicle degeneration without a corresponding reduction in the number of healthy follicles brought us up against the dogma of a fixed supply of oocytes," Tilly says. "The only probable interpretation was that the postnatal ovary had to be retaining the ability to make ne...Gene mutation found for a form of juvenile-onset motor neuron disease
...ing encoding of DNA, and thereby contribute to the degeneration of these nerve cells. The disease studied is a rar...ow more about the underlying basis of motor neuron degeneration to design rational treatments, to prevent the onset of ALS, or to slow down the rate of cell degener...From algae, weeds and people: new genetic clues to complex obesity syndrome
...controlled appetite, obesity and diabetes, retinal degeneration and some kidney problems, says Katsanis....Cancer drug resistance research leads to possible therapeutic target for Alzheimer's disease
...hown that the deterioration of myelin triggers the degeneration of complex neural connections," Tew said. "This may be due to genetic factors as well as the brain's own process of increasing cholesterol and iron levels in middle age. "In samples of brain sections from Alzheimer's patients, the ABCA2 protein show...U. Iowa muscular dystrophy discovery may lead to new treatment approaches
...o interact with other proteins and leads to muscle degeneration and brain defects in these muscular dystrophies. LARGE protein is mutated in patients with congenital muscular dystrophy 1D. In the Nature Medicine article, Campbell and his colleagues examined the effect of restoring expression of LARGE in mice that...Yale researchers receive $4.5 million grant to study spinal cord repair
...preserve neurological function in MS by preventing degeneration of nerve fibers within the spinal cord and brain. CERF also investigates a combination of molecular and cellular approaches with rehabilitation therapies, and is currently assessing the use of body-weight supported, robotic treadmill therapy to res...Mitochondria in spinal cords is ALS target according to UCSD medical researchers
...ic neuron cells. The result is ALS, a progressive degeneration of motor nerve cells in the spinal cord that leads to wasted muscles and premature death in middle-aged adults. Found in all cells, mitochondria provide cellular energy in their role as the body's power generators. In addition, mitochondria are intr...Tracing a killer's path in Lou Gehrig's disease
...om the spinal cord may be selectively targeted for degeneration in models of ALS," wrote the researchers. "We propose that the universal association of SOD1 mutant exclusively within affected tissues represents the common property of these mutants that initiates a cascade of damage," they wrote. In a second paper...Gene defects found in age-related macular degeneration
...archers who seek to understand age-related macular degeneration (AMD). "The clinical entity that we call AMD is actually as many as fifty diseases," said the study's lead author, HHMI investigator Edwin M. Stone , who is at the University of Iowa Carver College of Medicine. "They simply look so similar that clin...Study by Tufts biologist provides window into progression of some degenerative diseases
...urodegeneration in Huntington's disease and muscle degeneration in myotonic dystrophy." Although some of the reasons for the degeneration are understood, activation of the checkpoint pathway is a possible contributor that wasn't recognize...