CWRU scientists demystify protein at root of arthritis
... areas may be more susceptible to the enzymes that degrade cartilage in osteoarthritis." Eppell worked with Brian A. Todd and Jayan Rammohan, graduate students in the CWRU department of biomedical engineering, using funding from the National Institute for Arthritis and Musculoskeletal Research. The researche...PNNL gathers most complete protein map of 'world's toughest bacterium'
...odurans is of interest because of its potential to degrade radioactive materials, its ability to withstand high levels of radiation and its impressive DNA repair capabilities. The Guinness Book of World Records once called it the world's toughest bacterium. "We've been able to see more of the proteins, espec......ls contain several DNase enzymes that specifically degrade DNA. During apoptosis, a DNase called CAD is released from its inhibitor, ICAD, and thereby activated to chop up DNA inside the dying cell. The engulfing cell also houses DNases, including DNase II enzymes inside the lysosome (a specialized cellular ...Another job discovered for a master metabolic off-switch
... might also act on phosphodiesterases to help them degrade cyclic AMP," said Lefkowitz. "All the textbooks sa...receptors -- by recruiting PDEs to the membrane to degrade cAMP. In their initial experiment, using chemicals that switched on receptors, the scientists traced...Potential new treatment for Gaucher disease developed by scientists at Scripps Research Institute
...rly and find its way to the lysosome, where it can degrade the fatty substance. The chaperone targets the most common Gaucher mutation, which is referred to as "1226G" or "N370S." Virtually every Jewish patient with Gaucher disease has this beta-glucosidase mutation. A therapy based on these chaperones has ...INEEL competes successfully for DOE EMSP funding
...am plans to create tiny particles of material that degrade solvents, and study how well they can be put into ...study how quickly naturally-occurring microbes can degrade a common solvent pollutant, trichloroethylene, a remediation approach being used at the INEEL. The g...Microorganisms are cleaning up Boston Harbor, UMass study finds
...ong as there is sulfate in the water, the PAHs can degrade slowly." Sulfate is a salt of sulfuric acid, and is naturally abundant in seawater, according to Lovley. These microorganisms use sulfate the same way that humans use oxygen. Whereas we use oxygen to oxidize the food that we consume, these microorg...INEEL researchers discover that concrete degrades nerve agent and can predict rate of decay
...ted changes. "At the time, we didn't know VX would degrade on concrete," said INEEL chemist Gary Groenewold. ...degrees Celsius (75.2 degrees Fahrenheit), VX will degrade to 1 percent of its original concentration within 15 hours, and dwindle to a mere 10-millionth of or...Scientists target microorganisms to break down toxic pesticide
...tes. By identifying microorganisms to specifically degrade endosulfan, these researchers were able to drastically reduce the toxic residues in the soil. The results of this study are published in the January-February issue of the Journal of Environmental Quality. Various environmental samples were collected ...Science picks -- leads, feeds and story seeds (February 2003)
... make radio communication difficult or impossible, degrade global positioning systems, damage satellite electronics, and induce ground currents that can damage high-voltage power grids and enhance pipeline corrosion. USGS scientists who study geomagnetism play an important role in the study and diagnosis o...Polymers promote nerve regeneration
...ly poly(lactide-co-glycolide) and polyanhydrides, degrade when exposed to water, and Mallapragada has worked to develop thin film polymers that bulk degrade in layers over a period of time ranging from a few days to almost a year. To put the microscale gro...UC Riverside scientists isolate microorganisms that break down a toxic pesticide
...isolated using endosulfan as a sulfur source could degrade about 70% endosulfan." Total average annual use of endosulfan is estimated at approximately 1.38 million pounds of active ingredient. Classified as an organochlorine (the same family of pesticide as DDT and dieldrin), endosulfan and its breakdown pro...Australian overturns 15 years of nano-science doctrine
...haped microcantilevers actually maximise twist and degrade the performance of the instrument. "This finding is surprising and counterintuitive, contradicting accepted practice and manufacturing standards worldwide where the V-shaped cantilever is the standard due to its alleged advantages," says Sader. Users...Scientists re-evaluating the meaning of 'desertification,' Duke ecologist says
...cause sensitive dry land environments to sometimes degrade to points of no return. "The problem is that a single word, desertification, is used to characterize a myriad of issues and in doing so is the root of so many controversies," the Duke biology professor said in an interview. "Those issues range from ...Researchers discover gene that contributes to sense of balance
...ed during development, and that they progressively degrade throughout life. Scientists believe otoconia become eroded during normal aging, which can lead to balance disorders. But little is understood about how otoconia develop, and whether it may be possible to stimulate the production or regeneration of th...Genome of a major member of gut bacteria sequenced
...t the correct combination of enzymes that grab and degrade carbohydrates can be expressed when nutrients are available. In addition, the organism has a rich repository of genes that allow it to manufacture carbohydrates on its own cell surface. By changing the features of this carbohydrate mask, the organism...Alzheimer's protein jams mitochondria of affected cells; resulting 'energy crisis' kills neurons
...ins -- inaccessible to enzymes that might normally degrade them -- cellular function is steadily and inevitably reduced until cell death, reached when APP succeeds in suffocating all the cell's mitochondria. Avadhani and Anandatheerthavarada's results put a dent in cell biology dogma, which holds that each o...Sunlight converts common anti-bacterial agent to dioxin
...t was also known that sunlight causes triclosan to degrade in the environment. But it had not been known that the natural degradation resulted in dioxin, said researchers Kristopher McNeill, an assistant professor of chemistry, and William Arnold, assistant professor of civil engineering. They discovered tha...White noise delays auditory organization in brain
... acquired or inherited disorders could potentially degrade the signal at any of these points, masking the sensory input. From these findings, we theorize that disorders, for example, such as focal epilepsies or defects in myelination, might affect the fidelity of this signal, disrupting normal development of...Microgel polymer beads may provide general vehicle for vaccines, gene therapy
...igestive chamber before the acids have a chance to degrade the antigens. The technique avoids a big problem of similar techniques: the cell's stomach acids often destroy the protein antigens before they can be used for display on the cell surface. Without such display, the immune system cannot detect the pre...