Novel therapeutic bortezomib moves to phase II trial in lung cancer patients
...or that blocks the signals cancer cells rely on to degrade cellular proteins. The result is a buildup of proteins that hastens cell death. Bortezomib has been approved by the Food and Drug Administration for the treatment of multiple myeloma, but had not been tested before in non-small cell lung cancer. "Bo...Study finds first evidence COX-2 enzymes can regulate DNA damage
...emoved from the cells before it would have time to degrade into genotoxins but under abnormal circumstances such as oxidative stress, degradation could take place. Dr. Blair says these studies provide the first hint that COX-2 enzymes are responsible for DNA damage and that inhibition of this damag...Salmonella infects cells and saves itself by altering host membrane lipids
...specialized compartment, the lysozome, designed to degrade foreign or unwanted materials. Once the bacterium is engulfed, it takes only about 30 minutes to reach a lysozome. Therefore, to survive and replicate, bacteria must act rapidly to avoid this pathway to degradation. Salmonella, the bacterium t...Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
... which is involved in gene expression. They either degrade the messenger RNA or block its translation. Cells in organisms from yeast to mammals make interfering RNA to shut off gene expression in development. Dr. Croce and his colleagues had previously shown that deletions in miRNA genes were involved in B-c...Common chemicals morphing into potential toxins in Arctic
...n used a smog chamber to simulate how the alcohols degrade in the atmosphere and discovered a previously unknown reaction that produced PFCAs. Martin says the team also found the compounds in polar bear liver tissue samples. Other studies are examining exposure levels in humans living in the far north. "It ...Water study yields a few surprises for New England
...rised to find that the quality of streams begin to degrade earlier than we thought as watersheds develop. Because of this finding, stream protection measures need to be in place even in the more rural areas of New England where development is beginning to occur," said Keith Robinson, USGS Hydrologist and pri...Argonne scientists determine structure of staph, anthrax enzyme
...containing iron in hemoglobin transport the heme, degrade the heme and then extract the iron. Before the protein can bind the hemoglobin, it has to be attached to a specific position on the surface of the cell. The bacteria use a specific enzyme to accomplish this; in this case it is sortase. "Sortase woul...New diagnostic technology helps justify earlier cataract surgery
...mportant treatment issues is determining when they degrade vision to the point that the patient is at an increased risk of falls or accidents, or that their quality of life has been significantly undermined. (An August 2002, study reported in the Journal of the American Medical Association found that catarac...RNA could form building blocks for nanomachines
...oncerns right now is that, over time, RNA tends to degrade biologically," he said. "We are already working on ways to make it more resistant to degradation so that it can form long-lasting structures." Guo said that though applications might be many years away, it would be most productive to take th...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...es, Bogyo said. "Proteases take other proteins and degrade them into little bits, and so it's hard to figure out what those proteins were doing," he said. "We're beginning by focusing on individual proteases, seeing what happens when you shut down a specific member of that family. And I think we're going to ...Breaking new ground in germ cell guidance
...te phosphatases (LPPs), which it had been proposed degrade an extracellular substrate, thereby creating an environment unfavorable to germ cells and steering them toward their gonadal destination. The overexpression of either gene in somatic cells had also been shown to cause the death of pole cells, indicat...Environmental decontamination, greenhouse gases, and the genome of a methane-loving bacterium
...hane to reduce global greenhouse gas emissions, to degrade chlorinated hydrocarbons and other persistent pollutants, and to produce protein for animal feed. ...Indiana University, EPA to study airborne PCBs
... be toxic to humans. PCBs also take a long time to degrade naturally. In spite of the fact that their U.S. production ceased in 1977, PCBs persist throughout the country. "Their concentrations are indeed declining, but fairly slowly," Hites said. "In fact, it's only through the long-term IADN project that we...Student science contest participation influences study, career choices, alumni say
... were being used by commercial waste management to degrade wastes. Working along side scientists inside a company's lab "gave me perspective on what careers were out there in the life sciences". Merson went on to do medical research and for the past four years has worked for SHI Consulting, a life s...