Reduced-calorie diet adds nearly two years to dogs' life span
...ilitating condition for many large-breed dogs, was delayed significantly by reduced food intake. Overall fre...y of life." Caloric restriction also significantly delayed the onset and severity of other ailments. Dogs on a restricted diet who developed such conditions w...Early evaluation critical for kidney disease patients' survival
...hese probably include poor access to primary care, delayed or absent referral to a specialist from a primary care doctor and patients' lack of information about the importance of early intervention. "There also are many people who have chronic kidney disease and may not know it, so they may not be under a p...Study backs theory that accumulating mutations of 'quiet' genes foster aging
...olleagues raised fruit flies to test the effect of delayed mutations. The new study found that the deleterious effects of mutations on reproduction rose dramatically with age during the reproductive years in both genotypes -- homozygous (those with many identical genes, or inbreeding) and heterozygous (those...Families with two or more children with autism sought for $10.2 million study
...olving 75 children with autism, 40 developmentally delayed children and 40 normally developing ones. This study, begun when the children were toddlers, has shown that 3-year-olds with autism have larger than normal brains and that these children also have difficulty recognizing and distinguishing emotions fr...Pain-relief drug may prevent lung problems, blindness in premature infants
...ssociated with a number of side effects, including delayed brain and body development and increased risks of cerebral palsy. "This study indicates that Celebrex may be a more suitable alternative than dexamethasone in preventing the growth-suppressing effects of oxygen," Modanlou said. "We will still need to...Experimental 'gene switch' increases lifespan with no ill effects
...animation, known as the dauer, and reproduction is delayed until food is restored and they come out of this phase. But the new study shows that if the gene is not inhibited until the organism already is a young adult, the worms gain increased longevity without experiencing a dauer stage or compromised reprod...First results from novel anti-angiogenic drug trial in patients
...epeated treatment cycles to avoid discovering late delayed cumulative side effects. Among the side effects already seen were two unusual phenomena. The drug tanned the skin in several patients, turning it a golden colour (the drug is yellow and accumulates in the skin). But this effect wore off within a wee...Versatile immunosuppressant drug may have new role in radiotherapy for cancer
...r) that combined rapamycin and radiation treatment delayed regrowth of glioblastoma multiforme (GBM)[4] human tumours in mice for an average 19 days compared to treatment with rapamycin alone. In contrast, radiation treatment alone or rapamycin alone had no effect on tumour growth compared to control treatme...Inhibitor of novel cancer target, LPAAT-beta, demonstrates selective anti-cancer effects
...29 colon cancer were treated with the compound, it delayed tumor growth significantly without producing toxicities. Similar results were achieved with related compounds in mice with Lewis lung cancers or NCI-H460 human lung cancers. "These data affirm what we had previously noted in our initial studies th...New theory explains economic growth in terms of evolutionary biology
...rental resources and investment in their offspring delayed the evolutionary advantage of a preference for high-quality children," said the authors. In fact, according to the theory, a switch back to a quantity emphasis began to take place in the 20th century. "During the transition from stagnation to growth,...UV radiation may not be a factor in amphibian declines
...in years with heavy snow accumulation breeding was delayed until mid- to late June. These observations were combined with satellite-based estimates of UV-B. The scientists found that frogs breeding in May are exposed to less UV-B than frogs that breed in June. Another study by scientists at Oregon State Univ......ngly, the effect occurred even if reactivation was delayed for 45 days after training, a time when declarative memory is independent of the hippocampus. In fact, we found that if you lesion the hippocampus 45 days after conditioning, there is no effect. Therefore the memory of the context has to be independ...Animals can be induced to cooperate if partners reciprocate and benefits accumulate
...nditions to see whether reciprocal behavior and/or delayed rewards would lead to a stable pattern of cooperat...g) animals may have a superior ability to wait for delayed rewards--a hypothesis Stephens said should be tested. As for humans, nature and history have already...Effects of rare, devastating disease linked to shrinking of cells' telomeres
...e symptoms related to telomere shortening would be delayed or might not show up at all. So the scientists interbred these compound mutant mice to generate successively shorter telomeres so that they could measure the effects of telomere length on the disease manifestations. In the mice with shortened telome......rols with two copies of "met" scored 40 percent on delayed recall, compared to 70 percent for those with two copies of "val." BDNF gene type had no significant effect on tests of other types of memory, such as semantic or working memory. The researchers then measured brain activity in two separate groups of...Abnormalities in cellular anchoring protein cause fatal heart syndrome
...4 seconds, but in people with LQTS, that period is delayed by up to 0.5 seconds. Many patients with the disorder never experience symptoms, but others are at risk of developing abnormal heartbeats and cardiac arrhythmia. HHMI investigator Mark Keating and his colleagues have shown that several forms of L...Mutation causes specific arrhythmia and sudden cardiac death
...people with LQTS, this period of recharging can be delayed up to 0.5 seconds, which put these patients at high risk for arrhythmias. This constant back-and-forth electrical stimulation and recharging is controlled by different ions passing in and out of the cell, which alternately changes the cell's polariza...24-Wk data from CONTEXT trial comparing GW433908/ritonavir QD & BID to Lopinavir/ritonavir BID
...among other things, the risk that approval will be delayed or will not be obtained, that 908 will not be commercially successful, and those other risks listed under Risk Factors in Vertex's form 10-K filed with the Securities and Exchange Commission on April 1, 2002....Phase III, 48-Wk NEAT study results comparing GW433908 to Nelfinavir presented today
...among other things, the risk that approval will be delayed or will not be obtained, that 908 will not be commercially successful, and those other risks listed under Risk Factors in Vertex's form 10-K filed with the Securities and Exchange Commission on April 1, 2002....The timing of hormone replacement therapy could be key to success
...eries. In contrast, when estrogen replacement was delayed for a period comparable to six years in women, there was no benefit on the heart's arteries," they wrote. Clarkson and Karas said the data they reviewed support their theory that HRT may be able to maintain vessel health when it is initiated in youn...