Dengue infection more serious for elderly persons
...rder to avoid complications that might result from delayed identification and treatment of severe dengue infection." The researchers encourage clinicians to check for mild hemorrhage, microhematuria [blood in the urine], occult blood in stools, and increased capillary permeability ["leakage" from the smalles...Gene therapy prolongs survival, slows disease progression in ALS mice
... gene, called insulin-like growth factor-1 (IGF1), delayed disease progression and prolonged survival. The authors report that their results demonstrate substantial behavioral, functional, and pathological improvements in a clinically relevant mouse model of a motor neuron disease. Says Fred Gage, "Adeno-as...Salk news: gene therapy for Lou Gehrig's disease
...equent transfer of IGF-1 to neurons dying in ALS), delayed disease onset by 31 days and expanded the mice's life span to a maximum of 265 days, compared to 140 days for the untreated mice. IGF-1 was also able to extend life spans by 22 days when injected after symptoms appeared, indicating the method's poten...Gene therapy delays death in mouse with symptoms of Lou Gehrig's disease
...s not a cure, but a novel form of gene therapy has delayed symptoms and almost doubled life expectancy in mice with the equivalent of Lou Gehrig's disease, a team from the Salk Institute and Johns Hopkins reports in the Aug. 8 issue of Science. In experiments with mice destined to develop the condition, inj...Splitting hairs: GATA-3 function in hair follicle development
...ddly bent, and displayed irregular thickenings and delayed emergence through the skin. However, for as unusual as their whiskers appeared, the remainder of the epidermis of these pharmacologically rescued GATA-3-null mice appeared to function properly. When Dr. Fuchs and colleagues grafted dorsal skin from ...Findings offer further understanding about growth and development in young male gymnasts
...ering normal hormonal development. This has led to delayed pubertal onset, delayed age at first menarche and failure to develop mature skeletal structure. In males, despite evidence t...Can heart failure impair thinking?
... neurological deficit of HF patients appears to be delayed recall. This memory dysfunction suggests specific neural damage related to the hippocampus or frontal lobe or associated circuitry, rather than generalized deficits over the entire brain. Approximately one-half of chronic HF patients exhibit obstruct...JCI Table of Contents, 1 October, 2003
...fection. This deficiency is most pronounced in the delayed reconstitution of CD4+ T cells and the rate of rec... administration has clinical potential to overcome delayed T cell engraftment and resulting immunodeficiency in certain transplant recipients. TITLE: IL-7 enh...JCI table of contents, 15 October, 2003
... absence of p40 expression within the CNS, EAE was delayed and less severe. This study suggests that cells resident in the CNS can control the degree of T cell encephalitogenicity and that therapeutic intervention by targeting the IL-12/23 pathway may provide a powerful inhibitor of multiple sclerosis diseas...Imperial researchers show novel flu treatment eliminates symptoms in mice
...c symptoms of flu. When treatment with OX40:Ig was delayed for several days after infection, until the mice had lost 20 per cent of their body weight and OX40:Ig was administered, symptoms were reversed. Re-infection also indicated that the ability of mice to respond to a second infection was not affected b...Landmark study offers new information about breast cancer genes
...Exercise and appropriate weight during adolescence delayed the onset of breast cancer in women who carry the mutation. Findings that relate the date of birth of the subjects to the risk of breast cancer: Women in this study who carried the breast cancer gene born before 1940 developed breast cancer later i...Exercise and healthy weight delay cancer even among women with highest genetic risk
...risk, exercise and healthy weight as an adolescent delayed the onset of breast cancer. "It was a surprise, ...riate weight during their adolescent years clearly delayed the onset of breast cancer." "The possibility that lifestyle changes such as increased exercise and ...Diet may improve cognition, slow aging, and help protect against cosmic radiation
...roductive abnormalities, particularly premature or delayed sexual development. "In the last decade, we've also come to understand that sex hormones play an important role in the maturation of other, non-reproductive systems," says Russell Carr, PhD. "It's now known that estrogen is a key player in the develo...Genetics mutations resulting in delayed puberty are focus of MCG study
...e of Georgia physician-scientist. "Irreversible, delayed puberty is fortunately rare," said Dr. Lawrence C....erone and sperm. "When patients present to us with delayed puberty, it usually means they are not making either estrogen or testosterone," said Dr. Layman. "A...Dying nerves cause even more harm after spinal cord injury
...used the secondary injury. The researchers found a delayed reaction . . . the axons near the injection site began breaking two days after injection. In related work, these researchers have found evidence of axons breaking up to fourteen weeks after an injury. "While we're not sure why the axons begin to brea...Pesticide delays sexual maturation
...hildren exposed to the pesticide endosulfan showed delayed sexual maturity compared with similar children who were not exposed, according to a study published today in the December issue of the peer-reviewed journal Environmental Health Perspectives (EHP). Endosulfan also appears to interfere with sex hormon...Doppler ultrasound predicts risk of miscarriage
... the placenta do not properly form or are slightly delayed in development, the heart does not get the support required." The Doppler technology provides higher sensitivity and higher specificity than conventional ultrasound and may eventually allow for early intervention, according to Dr. Birnholz. He specul...Plant immune system's 'take two aspirin' gene, offers hope for disease control
...B cell and T cell-mediated acquired immunity for a delayed response that can take weeks to develop.) The Klessig laboratory discovered the presence of the SABP2 protein in plants in 1997. But it took five years to purify the protein, which occurs naturally in "excruciatingly small amounts," then to clone t...Oral drug showing promise for breast cancer prevention in a mouse model
...ly develop breast tumors in approximately 230 days delayed the formation of ER-negative tumors to more than 310 days. ZD1839 also reduced proliferation of normal breast cells by 20.3% and of tumor cells by 42%. In an accompanying editorial, Dennis J. Slamon, M.D., Ph.D., of the University of California at ......pstein-Barr virus transformation of B cells can be delayed by a strong natural killer cell burst," says Mnz. "Now we are studying how this herpes virus may be targeted by natural killer cell responses." By learning both what molecular signals activate natural killer cells in their dialogue with dendritic cel...