Biota to develop new influenza drug/Relenza® has positive results in high-risk patients
...ation neuraminidase inhibitors, are, like Relenza, delivered directly to the site of infection in the lungs. They will therefore still have the key advantages to patients of Relenza. These are: low effective dose, almost instant onset of action, minimal systemic absorption resulting in negligible systemic side...Chemists report new approach to synthetic fragments of medically important Heparin
...eparin are well over $2 billion a year. It must be delivered intravenously, though an oral version is in development. Heparin is extremely effective in preventing blood clots following surgery. Heparin's value is not limited to its anti-coagulant properties, however. There's mounting evidence that Heparin is ...Parents' escape drinking evokes children's negative response to alcohol smell
..., or a neutral odor (mineral oil). The researchers delivered gentle puffs of air from the squeeze bottles into the children's nostrils and asked them if they liked or disliked the different odors. When the children liked an odor, they passed that squeeze bottle to a stuffed Big Bird toy; if they disliked an od...UF researcher: gene therapy effective in animal studies of Parkinson's disease
...kes the very important finding that it needs to be delivered to a specific region of the brain -- the striatum -- and not other potentially important sites," said Kordower, a professor of neurological sciences and director of the Research Center for Brain Repair at Rush. "As gene therapy for Parkinson's moves ......research field. Dr. Douglas received the award and delivered the 2000 AMLI Abbott/Erwin Neter Memorial Lecture on July 13 at the annual AMLI meeting in St. Petersburg, Florida. The title of this year's lecture, "Monocytes and Natural Killer Cells Probes of Innate Immunity and Disease" reflects a major resear...Global warming may be delayed by increase in ocean silica
...son, human activity has doubled the amount of dust delivered to the oceans today. Until now, scientists have been unable to propose an elegant mechanism to link this increase in dust with decreasing atmospheric carbon dioxide. In Paleoceanography, Harrison proposes just such a mechanism: The Silica Hypothesis...One-two punch knocks out fly genes
... also engineered into the flies. The team then delivered the gene into a test group of flies. The strategy they used to do so--standard among fly researchers--puts the gene into fly chromosomes at random, a drawback of this current method of introducing genes into flies. This key limitation has hamper...Targeted genetics presents promising data from cystic fibrosis clinical trial
... tgAAV-CF is safe, well tolerated, and efficiently delivered to the lung Seattle, WA-June 5, 2000-Targeted Ge... evaluated the safety and tolerability of tgAAV-CF delivered via nebulizer to 12 patients age 19-41 (median age 29) with mild CF lung disease. All patients in t...Bone produced from skin and gum tissue
...a surprising result: the engineered cells not only delivered the bone-forming proteins they were designed to secrete, but they also participated directly in bone formation. Current bone grafting methods involve harvesting a patient's bone marrow with a long needle or surgically removing a piece of bone, typica......n each of them - enough seeds to swamp the numbers delivered naturally by the stream. The invaders colonized all tussocks about equally, suggesting that the observed pattern was due to the supply of seeds and not resource availability or some other characteristic of the tussock. "Overall, this suggests tha...Scientists on scent of better coyote management
...s to absorb vaccines, says Mason. Vaccines must be delivered to the lining of the mouth to be effective, while a vaccine that is gulped would bypass the mouth and not work properly, he explains. Researchers hope that this method can be used to deliver rabies vaccines to coyotes, which are a primary carrier of ...Mountains of variables: The effect of landscape features on atmospheric deposition
...mospheric deposition, these doses of pollution are delivered through rain, snow, cloud, fog, rime ice or as gases and dry particles. Because gathering data from mountains can be expensive and difficult, measurements of atmospheric deposition are often made from single points, such as towers at the tops of mo...Targeted Genetics presents advances in systemic gene delivery technology
...m is capable of delivering genes systemically when delivered intravenously. Intravenous delivery of tgLPD-E1A, the company's second-generation cancer therapeutic, inhibited tumor growth in animal models of two different human tumors. The data were presented in an abstract titled "Systemic and Local Delivery of...New $4.2M research center at U-M seeks to see cancer more clearly
...resolution. It will be only the third such machine delivered to any institution in the world. These join a PET scanner that makes images of metabolic activity within the body with 2-mm resolution, and digital image processing laboratories directed by Charles Meyer, Ph.D., professor of radiology, that can even...New research proves fullerene can be cosmic carbon carriers
...ime, atmospheric gasses and organic compounds were delivered to the surface of planets via asteroid and comet s...er fullerenes were the original care packages that delivered volatiles along with the carbon necessary to establish life on Earth. "We now have a powerful new...Gene transfer improves function of aging hearts in animals
...ted into a standard experimental viral vector were delivered directly into the hearts of aged rats (26 months old) via a surgically implanted catheter. Three other groups of rats were used for comparison purposes: aged rats that underwent a similar operation without receiving a vector; aged rats that received...Stream size major factor in nitrogen reaching the Gulf of Mexico
...vious findings that most of the nitrogen pollution delivered to the Gulf of Mexico by the Mississippi River originates far upstream in the upper Midwest and Ohio Valley states. But this new USGS study also finds that within these regions there are large differences in the percentage of nitrogen reaching the G...Millennium and Wyeth-Ayerst announce the discovery of key potassium ion channel modulating proteins
...s on antibacterial drug discovery. Millennium has delivered nine antibacterial drug targets to Wyeth-Ayerst since that alliance began. Wyeth-Ayerst Research is a major research-oriented pharmaceutical company with leading products in the areas of women's healthcare, cardiovascular and metabolic disease ther......expert on comets, the space bodies that might have delivered the first organic chemicals and life-sustaining water to Earth. In fact, he and Ward, whose extensive research on the fossil record has provided key insights into prehistoric mass extinctions, frequently discuss the Earth's unusual character with stu...Jefferson scientists use gene repair technique to change albino mice hairs to black
...ntists, in what they dub "localized gene therapy," delivered a small oligonucleotide - DNA interspersed with small amounts of RNA - to the melanocytes, or skin color-producing cells. The "oligo" triggers the actual gene repair process. They both injected the oligonucleotide and applied it topically. The res...