New mouse model sheds light on lipoatrophic diabetes
...e in their bloodstream, glucose is not efficiently delivered to their body's cells, eventually resulting in severe eye, kidney, nerve and cardiovascular problems. A relatively rare disease in humans, lipoatrophic diabetes is thought to have a strong genetic component. With the new model of lipoatrophic diabet...Beyond patches and pills: the remarkable future of drug delivery
... are based on large protein molecules that must be delivered intravenously to avoid getting devoured in the stomach. This research looks for less invasive and more efficient ways to deliver therapies, such as patches, inhalers, ultrasound and, of course, pills, which still seem to be the overwhelming preferenc...Three inferior prefrontal regions of the brain found receptive to somatosensory stimuli
...iven the same stimulation and instructions as were delivered during the scanning sessions. All subjects were first stimulated on the toe, since the likelihood of rating the stimulus negatively appeared greatest at this site. Following the session of toe stimulation, subjects were asked to rate the pleasantness...Zinc supplementation reduces diarrhea and death in Bangladeshi children
...tists, evaluated the effectiveness of zinc therapy delivered often for a short period during diarrhea episodes in 8,070 Bangladeshi children and documented signifi-cantly lower rates of child morbidity, hospitalization and non-injury death in children treated with zinc. The incidence of diarrhea was significan...Cellular pathway includes a 'clock' that steers gene activity
...d for a short time, a single pulse of activity was delivered to the nucleus, like a single tick of a clock, activating a set of genes," said Andre Levchenko, assistant professor in the Department of Biomedical Engineering at Johns Hopkins. "But longer activation could produce more pulses and induce a larger ge...Researchers find mechanism responsible for neuronal death in prion diseases
... to a PrPSc like conformation. "When proteins are delivered to the cytosol for destruction, they are unfolded," Lindquist explains. "We think conversion occurs when these wobbly, sticky PrP molecules find others in the same state. If enough of them get together at the same time, they can acquire this new str...New study shows efficacy of gene therapy for Parkinson's disease
...ciated virus or AAV) to allow it to be efficiently delivered into the affected region of the brain. GAD is responsible for making a small molecule called GABA, which is released by nerve cells to inhibit, or dampen activity. After this gene therapy is introduced, the overactive cells are "re-set" and brain n...From moon rocks to space food: UH research spans 40 years
...he most complex university-sponsored payloads ever delivered by NASA, the Wake Shield was the first experiment to comprehensively characterize the wake vacuum of a spacecraft in low earth orbit. Materials grown in orbit have led to terrestrial applications such as bionic eyes, high-efficiency lasers and new se...Colorado U. to fly hardware, experiments on space shuttle, space station
... of the nine-day shuttle mission, the CGBA will be delivered to the International Space Station during the miss...o designed and built by BioServe and which will be delivered to the space station by Atlantis for a 50-day stay. The focus is on better understanding the role o...'OptIPuter' design for data-intensive computer wins $13.5 million NSF award
...sor arrays; and the "motherboard" uses standard IP delivered over multiple dedicated lambdas. Use of parallel lambdas will permit so much extra bandwidth that the connection is likely to be uncongested. "Recent cost breakthroughs in networking technology are making it possible to send multiple lambdas down a s...Gene therapy reverses muscular dystrophy in animal model
...hat did not raise a host immune response and which delivered the full-length, muscle-specific dystrophin gene. They showed that the full gene could be delivered to muscles of young and old mice, even well after severe muscle damage had developed. Also, they sho...UT Southwestern researchers develop vaccine against deadly bioterrorism toxin ricin
... The lethal dose, estimated at 450 micrograms, was delivered in a pinhead-sized hollow pellet, discovered during the autopsy. The Centers for Disease Control and Prevention ranks ricin on its "B" list of biowarfare or bioterrorist agents placing it in the category of a moderate threat....Collaboration to use proteomics to unravel mysteries of heart disease
...ons in our analysis of the small proteins and have delivered Novartis several releases of the protein database," Rose said. "Some interesting new proteins have already been synthesized, which validates our vision of an industrial-scale proteomics approach." Granger has no financial interest in either GeneProt ...Brain damage in infants not always tied to delivery
... composed of the next two healthy babies that were delivered by the same route, at the same age and with simila...uded from further study. The remaining dozen were delivered at an average gestational age of 35 weeks; four were premature. The average birth weight was 2,684 ...UCLA scientists develop prostate cancer tracking system
...dly. We'd be able to see that the toxin is getting delivered to the right place." Prostate cancer is the second leading cause of cancer deaths in American men. This year, about 189,000 new cases of prostate cancer will be diagnosed and more than 30,000 American men will die, according to the American Cancer So...Scientists at the Scripps Research Institute design gene-tipped tumor regressor 'smartbombs'
...I investigators first report how they successfully delivered nanoparticles with "reporter" genessuch as those encoding for luciferase or green fluorescent protein, proteins that glow like the tail of a firefly. These reporter genes allowed dramatic demonstrations of the specific targeting of the nanoparticles ...Decision making at the cellular level
... molecular switch to guide how the message will be delivered in the first place. "Our results add a layer of complexity to understanding how messages are communicated by cells," says Mark Donowitz, M.D., professor of medicine at Hopkins and a co-author of the study in the June 20 issue. "But by the same toke...Researchers developing technology to outsmart metastasized cancers
... As a result, these chemotherapeutic agents can be delivered more specifically to cancer cells while leaving the surrounding normal tissue unharmed. One form of this "Trojan Horse" therapeutic approach (folate-targeted immunotherapy) was used by a joint Purdue-Endocyte research team to successfully treat more ...Mooney to receive 2002 Blue Planet Prize in recognition of pioneering ecological research
...ov. 14 - to be followed by a commemorative lecture delivered by both winners at United Nations University in Tokyo on Nov. 15. Established in 1992, the Blue Planet Prize is given annually to two individuals or organizations for major contributions to solving environmental problems on a global scale. Past recip...New gene therapy tool successfully treats mice with hemophilia A
...e pieces of DNA cannot be effectively packaged and delivered using conventional DNA viral vector therapy. This new gene therapy tool will help treat hemophilia A as well as a host of other genetic diseases such as cystic fibrosis, sickle cell anemia, muscular dystrophy and some forms of cancer."...