New approach to gene knockouts reveals the 'master planners' of the skeleton
... genes affected the length of specific limb bones, demonstrating a role for those genes in patterning of limbs. "All these results tell us that these genes control global patterning of the skeletal structures, as opposed to forming the structures rib by rib, for example," said Capecchi. "This understanding also su...Protein holds promise as new diabetes drug target
...Studies performed at Vanderbilt were essential for demonstrating the importance of this enzyme," Magnuson said. After the glucokinase gene was cloned, other investigators identified mutations in the human gene. Mutations that cause the enzyme not to function properly have been linked to a form of diabetes called ...Cyclacel's biomarker technology shows that CYC202 induces cancer cells to commit suicide
...cal development and are also proving invaluable in demonstrating early proof of concept in humans. We believe that biomarkers will be a source of competitive advantage in pivotal trials and market positioning by helping identify responder patients based on their genetic profile. We are excited about the work of ...UN development work guided from space
... America in November 1998 was actually helpful in demonstrating how an operational EO service might work. The scale of the damage done was such that ESA's ERS and France's SPOT satellite systems were specifically tasked to acquire images in order to elaborate and supply cartographic and damage mapping products a......14 out of 15 hot spots with perfect DNA sequences, demonstrating that the mutation process had gone off without a glitch. "Remarkably, the results showed that AID acting alone on single-stranded DNA simulated the highly complex somatic hypermutation process that occurs in humans," Goodman said. Furthermore, the te...Development of prostate drug based on UT Southwestern research
...rial is the culmination of several decades of work demonstrating the importance of the 5-alpha reductase enzymes and the genetic or medically induced absence thereof in the development and progression of not only BPH, but also prostate cancer," said Dr. Claus Roehrborn, UT Southwestern's chairman of urology. "Seve...Bioinformatics/GIS program aim is to protect chimpanzees
... Birmingham physician who played a leading role in demonstrating that the AIDS virus afflicting the human race originated from a virus in chimpanzees. Other groups include TANAPA, the University of Rhode Island, National University of Rwanda, Management Sciences, Inc., international tour operators and others....European experiment hardware reaches the International Space Station
...raint. The 3D camera will be an invaluable tool in demonstrating the scientific capabilities of the ISS and in upgrading current virtual reality tools used in the ESA's Erasmus User Centre for training and awareness about the ISS and its facilities. The new crew restraint is an investigation to improve the curren...Plants and people share a molecular signaling system, researchers discover
...s the enzyme that produces S1P in plants, but also demonstrating that S1P production is triggered by the stress hormone abscisic acid. During drought, this hormone initiates a chain of cellular events that ultimately cause a leaf's pores, known as stomates, to change their shape in order to limit the amount of wa...UNC HIV-AIDS screening, prevention method could become national model for cutting illness
...ve testing without the counseling." A pilot study demonstrating the approach's preliminary success and promise appeared in JAMA last year. Besides Pilcher, UNC authors of the pilot study were Drs. Peter A. Leone and Joseph J. Eron of medicine, Marlene Smurzynski of epidemiology and Drs. Amy L. Peace-Brewer and Su...3-D imaging inside living organism, using quantum dots
... of the capillary wall from one heartbeat. Besides demonstrating the feasibility of microscopic angiography with quantum-dot labeling through skin and adipose tissue -- two of the most challenging tissue types -- the researchers said they had resolved several fundamental questions, including the fact that sometime...Emory University researchers uncover novel self-assembly of Alzheimer's amyloid fibrils
...tial of the emerging field of "synthetic biology," demonstrating the use of self-assembling elements that nature goes to great lengths to avoid, and converting them to new functional materials, Lynn says. "Nature goes to extreme measures to keep these amyloids from forming, but nature still hasn't figured out a ...Automated imaging of brain tissue, high-quality glimpses inside arteries
...solution at the microscopic scale. In addition to demonstrating that the laser-ablation process does not harm the tissue layers for imaging purposes, the researchers have been able to image tissues without freezing them (which causes damage) and have also shown that the process works with very soft tissue -- a re...Clinical study reports findings of combination therapy with DOXIL
...and urine by immune fixation, a bone marrow biopsy demonstrating less than 3% plasma cells, the absence of monoclonal plasma cells by immune staining of the bone marrow on two occasions at least four weeks apart, and no evidence of progressive disease by any other parameters. Eighteen patients (55%) had a major r...Ingenium publishes groundbreaking research on genetic basis for motor neuron degeneration
...ions. The findings reported are also important in demonstrating the value of random point mutation research in a model system since prior studies of the particular gene in knock-out animal models produced embryonic lethalities, with no discernable link to MND research. "The ability to correlate a biological pheno...Scientists report discovery of cancer-causing gene in childhood kidney tumor
...agnosis and treatment of people with this disease, demonstrating the potential and importance of translational research." The discovery grew out of the Dana-Farber team's previous research into MITF, a gene that controls the activity of a group of genes in skin cells known as melanocytes. Fisher and his colleagu...TSRI scientists show that rare genetic mutations increase susceptibility to sepsis
...more mutations in the sepsis populations." Besides demonstrating that the risk of severe sepsis increases with these mutations, which can be passed from parent to child, the study also suggests that it may be possible to protect people who are at risk. While not practical at the moment, eventually patients with mu...Jane Goodall to receive 2003 Environmental Citizen Award
...gnize its enormous complexity and diversity and by demonstrating its importance for their everyday lives. He is a two-time Pulitzer Prize winner, and a recipient of the National Medal of Science and the Crafoord Prize of the Royal Swedish Academy of Sciences....Hollow spheres make solid vaccine to protect fish
... immune system to produce antibodies in test fish, demonstrating a resistance potential against the viral disease. Vakharia said the technology promises to usher in new generation of recombinant vaccines for fish. The ultimate goal of the UMBI work, said Vakharia, is to offer aquaculture opera...Tourism leaders and conservation organizations to devise Caribbean conservation action plan
...p companies in the travel and leisure industry are demonstrating the importance of reducing biodiversity loss and turning conservation into a source of competitive advantage....