New study clarifies connection of brain and heart failure
...ome precedent for that suggestion in previous work demonstrating that electrical stimulation of PVN can increase renin release from the kidney and facilitate the renin response to other usual stimuli. But perhaps most important was a third finding, the survival of the AV3V-lesioned MI rats was compromised to the e...Bone marrow stem cells are a source of insulin-producing cells
...ponse to glucose and display other characteristics demonstrating that they truly function as pancreas cells, according to a new study by researchers from NYU School of Medicine. The study is published in the March 14 issue of the Journal of Clinical Investigation. The researchers caution that the findings ca...Richard A. Lerner and Peter G. Schultz to receive Paul Ehrlich and Ludwig Darmstaedter Prize 2003
... Lerner and Peter G. Schultz receive the Prize for demonstrating that antibodies produced by the immune system can catalyze any chemical reaction like enzymes. A large number of enzymatic reaction mechanisms could thus be explained in detail." The prize will be awarded on March 14, 2003, in the Paul's Cathedral in...BIDMC researchers identify source of preeclampsia
...linical and pathological symptoms of preeclampsia, demonstrating for the first time a clear cause and effect relationship between this protein and this disease." What is apparently happening, he explains, is that sFlt1 is binding to and "mopping up" another group of proteins, known as angiogenic factors. "Vascular...Rutgers' Tanzanian fossil reshuffles the deck on early human ancestry
...rther corroborates the work of other scientists in demonstrating thecapacity both to make tools and to use them in butchering meat for food, even at this early time horizon. Geological evidence in combination with the animal remains offered the investigators anopportunity to develop additional information about e...Cyclis Pharmaceuticals reports studies defining new mechanism for potential cancer therapies
... today announced publication of laboratory studies demonstrating that an experimental anti-cancer agent, -lapachone, can selectively kill tumor cells while sparing healthy cells. The studies suggest a novel and fundamental therapeutic mechanism for potential cancer drugs that activate cellular pathways for select...Taste receptor cells share common pathway
...restoring one modality did not restore the others, demonstrating that taste receptor cells are not broadly tuned across all modalities," said Zuker. The discovery of the common signaling molecules and the ability to selectively knock out or rescue taste modalities provide an invaluable tool for the next steps in u...High sugar blood levels linked to poor memory
...now more than 20 reports in the medical literature demonstrating that diabetics experience memory and learning problems that cannot be explained away by the presence of other conditions such as cardiovascular disease, which are often associated with diabetes. Diabetics have very high levels of glucose in the bloo...Expanding the genetic code--TSRI scientists synthesize 21-amino-acid bacterium
...and function of proteins," he says. In addition to demonstrating that life is possible with additional amino acids, the work is of great relevance to science and medicine because it enables scientists to chemically manipulate the proteins that an organism produces within the organism itself. This gives scientists ...OXiGENE announces commencement of Phase I/II clinical trial of Combretastatin A4 Prodrug
... a single agent, there was compelling imaging data demonstrating blood flow reductions to central tumor regions," said the trial's lead investigator, Peter Hoskin, M.D., clinical oncologist at Mount Vernon Hospital. "In several pre-clinical studies, CA4P was shown to augment the tumor-killing ability of radiation,...January GSA BULLETIN media highlights
...wsworthy items. Of particular interest is new work demonstrating the link between mass extinction and environmental change at the end of the Ordovician Period, when as many as 86% of species became extinct. Please discuss articles of interest with the authors before publishing stories on their work, and please mak...Stem cells put to the test in UNC studies
...l meeting, Dec. 13-18, and one is a landmark study demonstrating - for the first time - that genetically altered adult liver stem cells cloned from a male rat can turn into functional adult bone marrow cells in female mice. The accomplishment, known as hematopoietic transdifferentiation, may prove useful for tappi...New mouse model sheds light on lipoatrophic diabetes
... did not accumulate fat in their liver and muscle, demonstrating that the increased deposition of fat in liver and muscle is not a requisite feature of lipoatrophic diabetes. In addition to serving as a novel model of lipoatrophic diabetes, the IRS-1/3 double knock-out mice also reveal that IRS-1 and IRS-3 have p...Researchers discover gene that controls ability to learn fear
...ippocampus, but not the amygdala, thus genetically demonstrating that these two anatomical structures are different in their function. According to Kandel, further understanding of the fear-learning pathway could have important implications for treating anxiety disorders. "Since GRP acts to dampen fear, it might b...Plant-fungal symbiosis found in high-heat extreme environment
...funded by NSF's Microbial Observatories Program is demonstrating that when you look in interesting places, you discovery interesting life forms and interrelationships, such as these fungi and their plant partners."...Scientists discover role for Cdk4 in making cells cancer resistant
...or Ink4a/Arf tumor suppressor gene is inactivated, demonstrating that Cdk4 is required for tumorigenesis even when commonly mutated tumor suppressor genes are non-functional. This discovery that diminished Cdk4 expression steers cells into a protective state of senescence against oncogenes like Ras has significan...UCSD bioengineers develop first computer model that predicts disease variant based on genetic defect
... care. Our research is significant in that we are demonstrating the proof of concept for the first time." UCSD has formed a spin-off company, called Genomatica, to bring Palsson's in silico modeling technologies into commercial use....November GEOLOGY and GSA TODAY media highlights
...the Oligocene-Miocene boundary; and new techniques demonstrating that cellular biochemistry and physiology can be directly studied in fossils hundreds of millions of years old. Highlights are provided below. Please discuss articles of interest with the authors before publishing stories on their work, and please ma...Sauerkraut contains anticancer compound
...heir work also adds to a growing number of studies demonstrating that similar cruciferous vegetables (including broccoli, cauliflower and Brussels sprouts) contain anticancer compounds. Sauerkraut is a low-calorie, low-fat food that is second only to mustard as this country's favorite hot dog topping. Americans an......avior. They also bolster previous work by the Gurs demonstrating that although some gender differences develop as result of adaptive patterns of socialization, other distinctions are biologically based and probably innate. "As scientists become more capable of mapping the functions of activity in various parts of ...