Rosetta Inpharmatics approach enables identification of gene functions
...uly 7th issue of Cell, report significant findings demonstrating how high quality, comprehensive gene expression analysis data and powerful computational methods coupled with appropriate genetically modified organisms can be used to decipher the function of previously uncharacterized genes. As described in Cell, t...Gene found responsible for social amnesia
...ing their way around the maze as were normal mice, demonstrating that spatial memory was intact. Dr. Winslow was successful in restoring social memory formation by treating the knockout mice with oxytocin. In these mice, social amnesia disappeared. Like the normal mice, they again showed the characteristic decli...New therapy uses viruses to attack bacteria
...ng bacteria and not human cells. "These results demonstrating the proof of principle for phage therapy of V. vulnificus disease have implications beyond this specific disease," says Gulig. "With the emergence of antibiotic-resistant bacteria, new alternative treatments must be developed. Our studies could of...Cloning reverses aging in cow cells, Scienceauthors say
...ngering doubt about the utility of cloned cells by demonstrating that the process doesn't automatically rob cells of a normal lifespan. In fact, say Lanza and colleagues, cloning could supply a crop of youthful cells for a variety of uses, from medical applications like designing and transplanting replacement tiss...Advanced cell technology reports reversal
...blood cells or islets for transplant therapies. By demonstrating that the cellular clocks of these stem cells can be reset through the cloning process, ACT has shown that human therapeutic cloning may give scientists the potential to grow young cells, tissues, and organs for an aging population. "We couldn't be m...Vitamin D deficiency and bowel diseases connected
...eir paper is the first in which researchers report demonstrating a connection between vitamin D deficiency and inflammatory bowel disease (IBD). In her team's experiments, mice genetically engineered to spontaneously develop the symptoms of either Chron's disease or ulcerative colitis were also made vitamin D de......wed data that continue to validate earlier results demonstrating that M-Vax elicits an immune response in patients with advanced disease. Most importantly, the data suggest that the vaccine induces the expansion of novel T cell clones, targeted against the tumor. These T cells are involved in controlling immune ...Diversity of trees in forests may be caused by soil pathogens, IU biologists find
...t affect seedling survival in the same conditions, demonstrating that a biological agent is killing black cherry seedlings close to adult black cherry trees, Packer said. An important goal for future research is to determine how frequently this mechanism operates in temperate compared with tropical forests, and t...Searching for biochemical markers in children of alcoholics
...strong hereditary component; the second is further demonstrating the involvement of the endogenous opioid system in alcoholism. Wand himself studies the effects of opioid antagonists in the brains of nonalcoholic COAs. "This is a novel, important study," said Wand. "The findings highly suggest that people may b...Alexion and Yale discover harmful complement activation in patients with acute coronary syndrome
...dd significantly to these previous observations by demonstrating that severe and injurious complement activation occurs specifically in the coronary circulation and in the culprit coronary artery in patients with ACS." In the findings presented by Dr. Cleman and his colleagues at Yale and Alexion, blood sam...'Biomedical switch' regulates how cells stick together and communicates
... and signal transduction. A hard copy color image demonstrating cell adhesion dynamics is available upon request....Scientists develop most efficient mouse cloning strategy to date, create transgenic clone
... to term. All 8 died within 24 hours after birth, demonstrating that genetic make up of donor cells may be a key to survival of clones. "Embryonic stem cells from outbred mice created clones with better efficiency than embryonic stem cells from inbred mice. Thus, the ability to generate viable clones from ES ...Biodiversity yields dividends, finds pan-European research
...nce provides a vital contribution to the debate by demonstrating that both numbers of species and the types of plan...This project signals the beginning of a new era by demonstrating the power of "big ecology" to underpin environmental policymaking....Researchers discover location of a testicular cancer gene
...ontaneous testicular cancer by three weeks of age, demonstrating a strongtesticular cancer susceptibility gene is located on Chromosome 19. (Thecorresponding gene in humans is located on chromosome segment 10q26.) "The cancer results from a combination of genes in the host backgroundand a gene on the subst......logy at Plön, Germany, have beensuccessful in demonstrating how populations of small planktonic crustaceans(Daphnia) adapt to changing environmental stress by shifts in the frequencies ofresistant genotypes. Nelson G. Hairston jr., guest researcher from CornellUniversity, NY, and Winfried Lampert, director at...USGS studies wildfire ecology in the western United States
...a State University, Los Angeles, published a study demonstrating that for many species, smoke can also trigger seed germination. In some species smoke alone is sufficient to induce growth, while in others a combination of factors is required. Because of the diverse cues through which vegetation may respond to fire...Experiments illuminate workings of biological clocks
...tists confirmed that TIM isindeed "ubiquitinated," demonstrating that it is a target of the proteasome.Finally, the HHMI team's experiments also revealed that degradation of TIMdepended on the addition of phosphate to the protein by enzymes called tyrosinekinases. Such basic understanding of the biological clock ...Penn researchers find ovary removal reduces risk of breast cancer in women withBRCA1 mutation
...nal Cancer Institute. "This is the first study demonstrating a surgical approach to breast cancerrisk reduction among BRCA1 mutation carriers," says Tim Rebbeck, PhD, associateprofessor of epidemiology and principal investigator of the study. "Althoughwe're talking about a small percentage of women in the brea......ntiated into all the various types of blood cells, demonstrating that thestem cells had indeed remained immature. A large increase in the efficacy oftransplantation was observed with the stem cells that had received the chimeratreatment compared with cells treated with other cytokines. If the Weizmann Institute mo......However, scientists have previously had difficulty demonstrating the effect inhuman beings. The Centers for Disease Control reports that about 2.2 million Americans carrythe HIV virus, and more than 315,000 people in the U.S. were diagnosed with AIDSin the last decade. Numbers are much higher for CMV, which is the...