Trial shows which brain cancer patients benefit from temozolomide
...yme was currently being tested to see if it would deplete the activity of MGMT. Combined with this drug it was possible that temozolomide might also then become effective in patients with an unmethylated MGMT promoter, although it would be likely to increase toxicity to other organs as MGMT protected agains...Amyloid fibers sprout one step at a time
...ion of a relatively inert and stable amyloid might deplete the toxic oligomers and therefore be beneficial," he said. Weissman emphasized that basic studies of amyloid formation must be extended beyond the yeast prion model before the monomer-addition mechanism can be considered a general one. Thus, he and ...NASA satellites detect 'glow' of plankton in black waters
...en by bacteria. The bacteria consume the algae and deplete oxygen from the water that leads to fish kills. Chuanmin Hu and Frank Muller-Karger, oceanographers at the College of Marine Science of University of South Florida, St. Petersburg, Fla., used fluorescence data from NASA's Moderate Resolution Imaging ...Study examines future of species extinction, conservation
... in the environment. "The loss of species tends to deplete a community's ability to withstand environmental degradation," says Ives. Cardinale says that these changes in the food web and their indirect effects on organisms within a community can "change the order of extinction," basically foreshadowing new f...Transplant rejection averted by simple light exposure in Stanford animal study
...ation to avoid harmful side effects. "The trick is deplete the host Langerhans cells in a manner that doesn't cause other unwanted effects," he said....MGH study finds female mammals produce egg cells into adulthood
...e of follicle loss would be expected to completely deplete a fixed population of oocytes within a matter of days or weeks, female mice retain healthy egg cells well past one year of age. To make sure they were accurately measuring the rate at which follicles were dying, the researchers evaluated whether dea...Over land, sea and air, users give MERIS high marks
... shellfish. Alternatively the spreading blooms can deplete water of oxygen as they decay, causing larger fish to suffocate. Fish farms are especially vulnerable to algae blooms because fish cannot flee affected zones. The southern region of Chile has 360 fish farms in the ocean and 40 in freshwater, produci...Fourteen Grand Challenges in Global Health announced
...ents of disease: 7. Develop a genetic strategy to deplete or incapacitate a disease-transmitting insect population. 8. Develop a chemical strategy to deplete or incapacitate a disease-transmitting insect population. Improve nutrition to promote health: 9. ......ight. Subjects performed single-leg toe raises to deplete glycogen to approximately 20 mmol/l, and glycogen resynthesis was measured during the first four hours of recovery. Plasma samples were assayed for glucose and insulin at rest and during recovery. Results The findings revealed that gastrocnemius gl...Research: Coral reefs' decline actually began centuries ago
...he declines follow the same pattern. First, people deplete large predators such as sharks and large herbivores, which tend to be both easy to kill or capture and slow to rebuild their populations. Next to go are smaller animals, such as small fishes, followed last by sea grasses, corals and other so-called "...Researchers find mechanism that may determine early blood cell fate
...ts treating patients with severe cancer, which can deplete blood cells, or blood disorders such as sickle cell disease, beta thalassemia or alpha thalassemia. One common treatment has been to introduce HSCs into the body, where they produce new blood cells to counteract abnormal blood cells or replace absent...Wild ape population undergoing 'catastrophic' decline
...for the possibility that hunting and disease could deplete the population even in densely forested areas, he said. The new study is based on several surveys conducted between 1998 and 2002 in which teams of trained observers traveled through 4,800 kilometers of dense jungle and counted ape nests. In their pa......bonate rock and into the sediment below. The roots deplete sulfide from the sediment, effectively preventing sulfide from seeping into the bottom water. Once the levels of toxic sulfide are reduced, the habitat provided by the bush-like aggregations is made available to deep-sea animals with lower sulfide to...Cat parasite killing otters; Michigan's perch pressured; HACCP for medicine
...e bad news is that Eurasian ruffe will nonetheless deplete resources for yellow perch, an important native sport fish. With funding from Illinois-Indiana Sea Grant, Gary Lamberti, University of Notre Dame, and Martin Berg of Loyola (Ill.) University have been studying the relationship among Eurasian ruffe, r...Cloning pigs and drug discovery among 'hot' topics
...ategy involves giving a one-time dose of a drug to deplete recipient T cells just hours before transplantation before the antigen is introduced and then giving lower-than-usual doses of just one anti-rejection drug beginning one day after transplantation. Nine living donor-kidney transplant patients transp...Promising new therapies for deadly form of leukemia
...s of mice that had received radiation treatment to deplete their immune systems. After allowing the AML to develop fully in the animals, the scientists tested PKC412's impact on AML. "When we gave these mice oral doses of PKC412, we found one hundred percent survival at the endpoint of the study, versus one ...Rats depleted of salt become sensitized to amphetamine, show unusual growth of brain cells
...esearchers first gave a group of rats diuretics to deplete them of salt. Then they gave the animals a 3 percent saltwater solution, a mixture they ordinarily would not like or drink. This procedure was repeated two more times, with each treatment given a week apart. Then the animals' brains were examined ...UF research: methyl bromide more effective, economical for killing anthrax
... phaseout of the gas. It is one of many gases that deplete the Earth's protective ozone layer, and many uses will be eliminated after 2005. "When national security is a stake, we need to have the option of using this highly effective and economical fumigant to kill bacterial spores in buildings," he said. "......ry degrades soil health and poor farming practices deplete soil fertility, excessive fertilizer and pesticide use pollutes waterways, and monocropping (growing the same crop over hundreds of acres) diminishes biodiversity. Not only is the environment damaged by industrial agriculture, but the health of huma......Current ivermectin treatments, by comparison, only deplete the number of skin microfilariae for a few months, requiring continued doses to keep the parasite under control....