Tag: "derivative" at biology news

Chemical derived from vitamin-E shows early promise as cancer drug

... The researchers also investigated whether another derivative of vitamin E called RRR-alpha-tocopheryl succinate or VES, was as effective. VES was effective when administered by aerosol but was not effective when given orally, probably because it is broken down into an inactive chemical form by intestinal enzym...

Other highlights in the September 1 JNCI

... resistant to chemotherapy. Because fenretinide, a derivative of retinoic acid, targets a different molecular pathway--one that induces apoptosis, or programmed cell death--in neuroblastoma cells and is well tolerated, there has been interest in using fenretinide to treat neuroblastoma. In a study of fenretinid...

5AM Solutions releases Microarray Enterprise Manage(TM) Software

... industry standards for projects, samples, and the derivative microarray data. "This solution will result in scientists being able to share data quickly and obtain real insight into human disease," said Dr. Dietrich Stephan, TGen's director of neurogenomics and Chairman of a Microarray Consortium funded by the...

New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine

...ibody reactivity to agalacto-orosomucoid (AGOR), a derivative of ASOR, which differs from ASOR solely by the absence of the terminal galactosyl sugar residue. Therefore, the researchers considered that the anti-ASOR antibody reactivity is likely specific for the sugar moieties of ASOR, and that the terminal ga...

Sponge substance works well with yew derivative to thwart cancer cell proliferation

...eams up to enhance the performance of the yew tree derivative Taxol (paclitaxel) in preventing the growth of cancer cells, according to research published in the July 15 issue of the journal Cancer Research . Indeed, discodermolide, a novel drug isolated from the marine sponge Discodermia dissoluta, works with...

Anti-cancer agent built from anti-inflammatory drug

...ucing activities. This work generated a series of derivative molecules, all of which were far different in structure from celecoxib. Two of these proved to be 30 to 50 times more potent than celecoxib in inducing programmed cell death in cancer cells growing in the laboratory tests. One of the derivatives, OS...

Wisconsin chemists find a new chink in TB's armor

... its cell wall. The enzyme, in turn, depends on a derivative of vitamin B2 to make a cell wall building block. The work published today by Kiessling's group shows that the enzyme uses the vitamin in a new way, which also gives it a new biological role. Detailing the interplay between vitamin B2 and the enzyme...

Dietary supplement shows promise for improving immune function in the elderly

...erone (7-oxo DHEA), a more potent and natural DHEA derivative in the body that also declines with age, has been previously shown to enhance T-cell function in human lymphocytes. 7-oxo DHEA, commonly known as 7-Keto TM , is commercially available and can be purchased and used as a dietary supplement in the Unit...

More useful plants may sprout from gene role discovery

...r blue-green under UV light. Mutants, which lack a derivative of sinapic acid, appeared red under the UV light. This enabled the researchers to identify the gene responsible for synthesis of sinapic and ferulic acids, compounds that subsequently are cross-linked into cell walls. Altering the gene that programs ...

Can a plant that acts like poison ivy cure prostate cancer?

...n with all-trans retinoic acid (ATRA), a vitamin A derivative previously shown to be effective in treating leukemia. "We knew that ATRA is an effective synergist with TPA in treating leukemia cells in the laboratory, but prostate cancer is a different situation, probably involving different mo...

Should publicly funded research be free and available to the public?

...e any published article, or to use its contents in derivative works, such as databases, textbooks or other teaching materials." The PLoS board of directors promised to go head-to-head with other prestigious journals, such as Nature and Science , which require a subscription fee for Internet access, as well a...

Rensselaer awarded $2.7 million NIH grant to improve drug development process

...ify large numbers of promising compounds, known as derivative libraries. Yet the subsequent testing required to ...d expanding molecular libraries." To produce the derivative libraries, the researchers will use enzymes to react with promising compounds attached to small bead...

New ACOG guidelines on progesterone to prevent preterm birth praised by March of Dimes

...g a preterm baby may benefit from treatment with a derivative of the hormone progesterone, according to an opinion issued by the American College of Obstetricians and Gynecologists (ACOG) Committee on Obstetric Practice and published this month in ACOG's official journal, Obstetrics & Gynecology. However, the A...

Activity detailed for sirtuins, involved in metabolism, aging, gene expression

...l function. One part of the sirtuin was bound to a derivative of a molecule called NAD, which has a pivotal responsibility in metabolism it's needed to break down glucose. The other part of the sirtuin was bound to a specific site on a histone protein. Histones are primary players in controlling genes, and in ...

Cancer prevention pioneer receives AACR/Cancer Research and Prevention Foundation Award

High-dose retinoic acid a vitamin A derivative can prevent the occurrence of new head and neck cancers in patients initially cured by surgery, radiation therapy or a combination of the two, according to more than two decades of research by Waun Ki Hong, M.D. He and his colleagues at the Univers...

New findings suggest colorectal cancer origins are different than previously thought

...pole MS analysis, tert-butyldimethylsilyl (t-BDMS) derivative was prepared from free intracellular amino acids. NAP-amino acid derivatives were analyzed in a capillary GC-combustion IRMS system. Isotopomer ratios of the sample were obtained by electron-impact ionization and selected ion monitoring at mass-to-ch...

Vitamin D analog found to boost radiation

...alone and mice exposed to radiation and EB 1089, a derivative of vitamin D. Final tumor volume in animals irradiated with EB 1089 was approximately 50 percent lower than in the group that received radiation alone. The results of our latest study with EB 1089 are very encouraging, said lead author, Dr. Sujatha ...

March of Dimes awards $250,000 prize to pioneers in genetic research

...hat mediate signaling by retinoic acid (the active derivative of vitamin A) and its chemical relatives. His research has provided some of the most important contributions to our understanding of the consequences of vitamin A deficiency during prenatal development and childhood. A major discovery by Prof. Cham...

Iowa City chemist wins national award for drug research

...tional." Linhardt is now working on synthesizing a derivative structure of heparin, enabling pharmaceutical companies to manufacture the drug rather than harvest it from animal tissue. Linhardt received his undergraduate degree from Marquette University in 1975 and his Ph.D. from Johns Hopkins University in 197...

Structure of cog at the hub of metabolism reveals anti-ageing function

...ehow the enzyme releases energy by breaking down a derivative of glucose, succinate, to a smaller molecule fumarate. To determine what factors influence free radical production, the team compared the structure of succinate dehydrogenase to a similar enzyme, fumarate reductase. "Until now, it has been unclear wh...

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