Herpes research uncovers possible clue to Alzheimer's disease
...travels in the opposite direction what scientists describe as anterograde transport back down to the lip. The researchers also found that once coupled with the APP, the virus moves remarkably fast. "It's as if the virus hijacks a car which in this case would be the kinesin and the APP is the driver," expl...Scripps scientists link ozone to atherosclerosis
...ir report, Lerner, Wentworth, and their colleagues describe how ozone can trigger pathological changes in othe...ks down to produce toxic compounds. The scientists describe two such compounds, which they call the "atheronals." These atheronals were found in atherosclerotic...Conference to highlight medical advances resulting from 50 years of DNA knowledge
... at 858-534-3940 or ocme@ucsd.edu . Speakers will describe the impact of the DNA findings on real-world medical treatment, according to symposium coordinator Theodore Friedmann, M.D., UCSD professor of pediatrics; director, UCSD Program in Human Gene Therapy; and chair, Recombinant DNA Advisory Committee of ...JCI Table of Contents, November 3, 2003
...agues from the University of Alabama at Birmingham describe a gene-modified cell therapy utilizing the TRAIL molecule that successfully limits the incidence and severity of arthritis in a mouse model of collagen-induced arthritis and joint inflammation. The regime represents a therapeutic option for systemic ...Catching evolution's henchmen in the act
... at our disposal, we'll be able to more accurately describe bacterial strains, especially now that we know strains can recombine when they share the same host. Wolbachia strains may soon be described by the mosaic of genes they carry rather than by a single gene sequence. These acquired gene mosaics may ena...GenSAT (Gene Expression Nervous System Atlas) project announced
...s and programmer Nick Didkovsky. Heintz and Hatten describe this group as "some of the most talented young researchers we've ever worked with." Remarkably, Didkovsky, without prior exposure to science, worked closely with Hatten to build an operating system for Gensat from the ground up. The National Institut...World's largest forest birds may produce world's deepest bird calls
... an unsettling sensation, similar to how observers describe elephant vocalizations," said WCS researcher Dr. Andrew Mack, the lead author of the study. Known not only for their great size, but also their spectacular, helmet-like bony casques, and blue and red skin around their neck and head, Cassowaries are h...Young cancer researchers honored
...in that initiation. In 1992, his laboratory helped describe a protein called ORC, which is required to initiate replication. Since then, his team has discovered and characterized several other proteins required for DNA replication to begin, including one called the pre-replicative complex. He also contributed...Experimental hantavirus vaccine elicits strong antibody response in primates
...search Institute of Infectious Diseases (USAMRIID) describe using a naked DNA approach to develop a hantavirus vaccine. The technique involves vaccination with plasmid DNA that encodes a specific hantavirus gene. When the plasmid DNA is introduced into the cells of a vaccine recipient, using a harmless devi...How many fish in the sea? Census of Marine Life launches first report
... an intensive and expensive sampling program could describe the projected millions of new species in this currently inaccessible realm. The Central Waters - light and dark zones The oceans' central waters fill the vast bowl formed by the hidden boundaries. Sunlight penetrates and fuels photosynthesis of fo...Research collaboration identifies gene essential to puberty
...eutics and the University of Cambridge in the U.K. describe mutations in the gene for a protein called GPR54 that prevent both humans and mice from undergoing normal puberty and sexual maturation. This gene makes a receptor protein that probably is a key trigger of the hormonal cascade required for mammalian...Fourteen Grand Challenges in Global Health announced
...posed Grand Challenge included: Does the proposal describe a difficult and discrete roadblock to progress? What are the possible impacts on various diseases if the challenge is successfully met? Will envisioned advances be suitable for implementation in poorer parts of the world? The authors note that non...JCI table of contents, 15 October, 2003
...ues from Universidad Autnoma de Madrid, Spain, now describe a population of embryonic ancestor cells, called p...the London Centre for Paediatric Endocrinology now describe the clinical characteristics and functional consequence of only the second homozygous mutation withi...New gene for rare inherited paralysis may aid other spinal cord research, too
...evere form of HSP. In their paper, the researchers describe the gene and its encoded protein, as well as clinical analysis of affected subjects. The participation of 105 elderly men and women from a U-M Institute of Gerontology registry enabled this study, allowing the investigators to determine the range of ...National Science Foundation announces $14M planetary biodiversity inventory awards
...s announced an important new strategy to discover, describe and classify Earth's species. By some estimates a... Natural History and colleagues will inventory and describe the world's catfishes. Catfishes are extremely diverse, ecologically significant and commercially i...Staph aureus bacteremia in ESRD patients associated with substantial illness and higher costs
...ciated. The two studies presented at ICAAC clearly describe the clinical outcomes, associated with health care resource utilization and infection-associated costs of Staph aureus bacteremia among a large group of prospectively identified, hemodialysis-dependent patients. The full data from these studies have ...Diabetes drug may be new tool in treating breast cancer
...improve both diseases." Pestell and his colleagues describe a complex relationship between a cancer causing gene, Cyclin D1, and a cancer-blocking receptor called PPAR gamma, which is involved in fat cell development. They are respectively found in breast cancer tissue and normal breast tissue. When PPAR is "...Enzyme discovery sheds light on causes of rare disease, cancer
...t the complex exists, they also for the first time describe its composition, which includes nearly all of the proteins produced by the previously known FA genes plus PHF9 and several other new proteins. The FA complex normally promotes a cascade of changes in a biochemical pathway that ultimately leads to th......niversity of California-Los Angeles and colleagues describe the results of the first study to examine larval behavior versus passive-transport processes under natural and simulated water flow conditions. H. rhigedana is one of the most common parasitic flatworms found in southern California. Sexual reprodu...... John Radcliffe Hospital in Oxford, United Kingdom describe the generation of a novel transgenic mouse with endothelium-specific overexpression of guanosine triphosphatecyclohydrolase I (GTPCH), the rate-limiting enzyme in BH4 synthesis. The authors found that loss of endothelial BH4 in diabetes results from ...