Trojan Horse Virus Controls Hiv Infection
...ecessary first step. The report says the novel VSV described would be most appropriate for limitingHIV production in people with late-stage disease, but the Yale team has moved onto develop VSV constructsthat incorporate other HIV coreceptors such as CCR5 and CCR3 in an attempt toaffect HIV strains that target...Mutant Gene Not Sole Explanation For Hiv Non-Progression
A recently described genetic mutation does not fully explain why a small proportion of people infected with the human immunodeficiency virus (HIV) remain completely well for a decade or more, according to invest...New Description Of Protein May Be Basis For Regulating Cholesterol
Scientists have described the three-dimensional structure and inner workings...l in the body. PROVIDENCE, R.I. -- Scientists have described the three-dimensionalstructure and inner workings of a terpene synthase, a type of protein thatsynth...Gene For Last Major Form Of Batten Disease Discovered
...enzyme to known proteins and gene segments thatare described in databases available through the National Center...des for a type of enzyme that has neverbefore been described in humans or other mammals. Nonetheless, it appears to beone of the most common protein-degrading e...Smoking Mice Lead To Emphysema Breakthrough
... are apparently immune toemphysema. The discovery, described in the Sept. 26, 1997, issue of Science,throws serious doubt on conventional theories of the disease, and researchersare already using the finding to search for potential new drugs. Steven D. Shapiro, M.D., associate professor of medicine an...Bowman Gray Scientists Find Novel Way To Block AIDS Virus
...ading whiteblood cells. This new strategy, described in the Oct. 1 issue of the journal NatureMedicine,... truly virus-free. In contrast, all othercurrently described genetically based anti-HIV-1 approaches can only inhibitvirus multiplication after virus infection. ...Further Proof That An Altered Rb-2/p130 Gene Leads To Lung Cancer
...Clinical Cancer Research , Giordano’s team described a study of 77 tumor samples from patients with surgically resected lung cancer. Similarly, they found that the less pRb-2/p130 protein expressed in a tumor, the more aggressive the lung cancer is. In related research reported in the Aug...New Form Of Gene Therapy Holds Promise For The Future
...y the micethemselves. This method of gene therapy, described in the October issue ofNature Biotechnology, may have great potential for treating chronic relapsingand remitting inflammatory diseases, such as rheumatoid arthritis, and organtransplant rejection. "Our long-range goal is to give patients the...Peutz-Jeghers Disease Gene Identified: Enzyme Loss Causes Polyps And Cancer
...8, 1998. Peutz-Jeghers syndrome was first described by Peutz (1921) and Jeghers (1949), but the genetic and biological basis for this unusual combination of symptoms remained a mystery until very recently. The typical dark brown melanin spots on the lips and around the mouth are easily rec...Doublecortin : A Novel Gene Involved In Cortical Development
...H/LIS syndrome. The X-SCLH/LIS syndrome was first described by French neuropaediatricians atSaint-Vincent de Paul hospital (Paris) and Reims, and is associated with severeforms of epilepsy and mental retardation. This syndrome consists of two similarmalformations of the cerebral cortex known as subcortical la...... key role in viral replication. Theachievement is described in a paper, "Hepatitis C Virus NS3 RNA Helicase Do...ucleic acid-bindingsite, as well as the previously described ATP-binding site that drives theenzyme's activity, amid three distinct structural domains of the NS3...STS-89 Will Carry Five Science Payloads From NASA/Marshall
...y Pharmaceuticals, principal investigatorfor DCAM, described two significant advances with such experiments. In onecase, scientists have grown crystals of HIV protease inhibitor that aresignificantly larger and of higher quality than any previous specimens.This will help in defining the structure of the protei...Handfish Steps Back From Brink Of Extinction
...h collected in the late 1790’s and was first described in 1804. Noted for its superb colouring and its tendency to ‘walk’ over the bottom on leg-like fins rather than swim, the spotted handfish is found only in the lower Derwent Estuary and adjoining bays and channels. Mr Bruce said the...Good Ergonomics Is Good Economics
... clothing products. Using methods similar to those described above for Imada's intervention, but with TQM as the primary objective, over a 70% reduction in lost-time accidents and injuries was achieved within a two-year period in both the production and distribution divisions of the company. Other benefits, su...Ant Pheromone May Aid Alzheimer's Patients
...laboratory as well as in wooded areas near Ithaca, described howone chemical cocktail serves several purposes for the ants: "This tiny antneeds help subduing prey that can be 10 to 15 times its size, so the ant returnsto the nest and tries to recruit some nest mates," Kern explained. "The antmarks the route ...Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy
...l replication. Conversely, as LIR scientists first described in 1987, even resting, latently infected cells can be induced to actively produce HIV when cytokines such as TNF-alpha are added. More recent LIR experiments have shown that other stimuli, such as the activation of...Low B Vitamin Levels Common In Many People Linked To Increased Heart Disease, Stroke Risk
...sease mortality rates. Associations should not be described as effects."The Cleveland study, part of a European Concerted Action Project, examined 750 people with atherosclerosis or blockages in the blood vessels of the heart, brain and leg. The individuals were younger than 60 and about 200 of them were wom...At Life's Most Sensitive Stage, Embryos Cope With Stress
..., who presented an overview ofthe topic; Epel, who described coping strategies that embryos use to repeltoxins,... and Susan Brawley of the University of Maine, who described strategiesthat marine algae use for reproductive success. Susan Lindquist of theUniversity of Chicag...Leftover Fetal Cells May Affect Development Of Scleroderma
...ter. "Traditionally, the autoimmune diseases are described as your cells attackingyour own normal, healthy tissue," Dr. Nelson, associate member of the FredHutchinson Cancer Research Center and associate professor of rheumatology at theUniversity of Washington, explains. "Our findings," she continues, "rais...Drug-Resistant Infection Once Found Only In Hospitals Now Present In Community
...ified risk factor. Risk factors for infection were described as previous hospitalization orfrequent antibiotic use, history of intubation, an underlying chronic disorder,presence of a catheter, history of any surgical procedure, or household contactwith a person who has identified risk factors. The researchers...