Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
...ecently, scientists couldn't intentionally design such drugs because they knew so little abo... Wang. "This in turn has implications in the design of anticancer drugs." The studies reveal that yeast topoisomerase II is he...New 'Twist' In Proteins Offers Possible Route To Improved Antibiotics
...o offers a new "twist"to biochemists attempting to design and construct proteins for use as medicinesand che... "Conceptually, it would seem feasible to design drugs that could actas antibiotics for all gram-negative bacteria, which produce about halfof all in...Children Become Gorillas In VR Zoo
...vior. "We instantly thought of Georgia Tech as our design partner,and we are extremely impressed with the sc... videos, contour maps,architectural blueprints and design layouts. "This is the most accurate and detailed model of a real outdoor areathat has ever been cre...Florida Researchers Discover Gene For Fatal Childhood Disease
...ed thisfatal disease," Kingsmore said. "Now we can design a diagnostic test. Andhopefully by understanding the gene we can forge better treatments forChediak-Higashi syndrome, and in the long run offer genetic therapy for it." People and mice who have Chediak-Higashi syndrome are much moresusceptibl...Humble Pocket Gophers Shed Light On The Genetic Fortitude Of Cheetahs
...analysis. They point to apparent weaknesses in the design of the skin-graft experiment; for instance, the researchers used skin from domestic cats as a control. More profoundly, detractors argue that ecological factors, such as habitat loss and predation, are more vital to cheetahs' survival than genetic di......d to co-ordinate a Europe wide research project to design high technology sensors to help monitor both the level of air pollution generated by vehicles and to restrict the amount of external air pollution (particularly CO entering drivers cabins in our increasingly polluted cities). The increasing level...Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
...understand that, we will be in a better positionto design selective and specific inhibitors or enhancers of the process."...Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases
... out, said Bastia,drug therapies will be easier to design as would gene therapies. The newresearch is the first step in that direction. The Duke researchers have shown that the RTP, rather than simply actingas a road block to replication, actually interacts with the helicase protein. "That's a m...Optical Microscopy Shines Light On Biology
...se of the way the probe is positioned. The new tip design avoids many of those problems and opens up significant applications in the biological sciences. "The cantilevered near-field tip brings less force onto the sample, making it much gentler," Dunn said. "The way we sense when the probe is near the sampl...A Sensor, A Switch, A Zipper: Protein Engineers Design Potential Tool
...ap like grape vines around each other. The design incorporated a selective binding site such...ollutants--but not quite yet. "The present design binds compounds such as benzene too weakly to beat your nose as a detection system," said Dr...Learning From Birds And Bees: Engineers Study Insects For Ideas On Tiny "Micro Air Vehicles"
...ntly differentfrom those that have guided aircraft design since the Wright Brothers'1903 airplane. "There m...it cost for theexpendable vehicles. The effort to design MicroFlyers involves many different technicalchallenges, so Blankenship believes only organizations ...Duke University Students Devise Devices For The Disabled
...dman recalled."She set me up with one of the chief design engineers, and he foundsome scrap parts that they hadn't used because of minor defects." At the beginning, the students were "just given a sheet of paperthat told us what the needs were," said Maciolek. "The first thingwe did was brainstorm without ...Chemists Compute Answers To The Origin Of Gout
...uter technology mean that many of today's chemists design new molecules on a computer screen long before they turn to messy, hazardous, and costly real chemicals. As modern research chemists they can combine their experience with modern information technology to cut costs and develop new materials and proce...NIH Team Discovers Endocrine Tumor Gene
...row. The discovery also provides a target for the design of drugs to prevent or treat both benign and malignant endocrine tumors. The MEN1 gene, a tumor suppressor gene--a gene that inhibits abnormal cell growth--intrigues researchers because it is unlike any of the tumor suppressors currently known, accor...Project Shows Native Bacteria Can Destroy Widespread Pollutant In Groundwater
...two contaminated aquifers at different depths. The design uses two treatment wells. One well was designed to create a bacterial-rich zone in the lower aquifer and to pump water from the upper aquifer to the lower one. The second well was designed to create a bacterial-rich zone in the upper aquifer and to p...... Each team, working within a $6,000 budget, had to design adevice, purchase or fabricate the parts, and assemble the finalproduct. Other projects developed this year included alightweight, inexpensive page-turning device for the disabled;and a scanning unit that inspects cracks inside elbow-shapedutility pi...Purdue-Made Soil Benefits The Environment
...ing with a laboratory in Maine to optimize the mix design of the topsoil. "Different combinations of these materials can be used to produce soil for different applications," Mikesell explains. "For example, we might come up with four or five types of soil or soil additives, some suitable for plants used for...UW Smogmobile Offers Cleaner, Safer Alternative To Gas Or Electric Cars
...tor. But Hertzberg is seeking a follow-on grant to design a more efficient motor that could achieve two to three miles per gallon in an optimally designed vehicle. This would enable the smogmobile, using a 100-gallon tank, to match the average range for gas-powered vehicles of 250 miles between fill-ups. As......mans. It is a relatively simple matter to design the EGS sequence itself, headded,because the methods are "all pretty well worked out." In fact, the specific EGSthat will restore sensitivity to a specific drug can be designed in a matter ofhours or days, and then produced with a machine called an ......ene was cloned. The researchers have also begun to design the first clinical studies using thegene as a marker to find out how it affects the course of breast cancer. "Do thepatients who make a lot of the message from this gene respond differently totherapy, do they have a different clinical outcome, are th...