Molecular motor implicated in tissue remodeling
...oose and disorganized where they would just end up destroying the matrix," Goldberg states. "By mechanisms that we are exploring further, they create a relation between cells and the structures in the matrix. It's a very elegant system." ...Belgian researchers explore revolutionary approach to angiogenesis
...g them. Exploiting tumour blood vessels instead of destroying them by anti-angiogenic drugs constitutes a paradigm shift in approach to angiogenesis," Dr. Feron told a news briefing today (Thursday 30 September) at the EORTC-NCI-AACR[2] Symposium on Molecular Targets and Cancer Therapeutics. The key to the abi...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...to prevent inflammation-induced tumor growth, thus destroying their advantage, and allowing TRAIL to tip the balance in its favor," Luo said. The study builds upon previous work in the Karin lab recently featured as the cover article in the August 6, 2004 issue of the journal Cell*. In that study, the resear...Bright idea could doom cancer and viruses, say Purdue scientists
...d render the cell unable to reproduce, effectively destroying it. The trouble is, such chemicals also kill many other healthy cells in the body in the process. "That's the reason cancer patients often lose their hair," Morrison said. "Hair cells, like many others in the patient's body, are also destroyed by the......mimics real conditions, rather than cutting-up and destroying the sample to fix it to a slide (as needed in traditional microscopy). SPIM shines a very thin slice of light through the sample and then systematically moves the specimen through the light sheet to capture images from each layer. No out-of-focus lig...Increasing international insect threat to stored food
...to poor farming areas of Africa is responsible for destroying stored grains and causing widespread hunger. "Since the early 1980's, the poorest farmers of sub-Saharan Africa have had to cope with the relentless spread of the larger grain borer, a pest inadvertently introduced from the Americas," he says. "Its ...MSU group reviews Berkeley venture into brave new science funding world
...fitable products, but if it does it at the risk of destroying the integrity of the university, essentially what you are doing is killing the goose that lays the golden egg," Busch said. The Berkeley-Novartis partnership also played out in uncharted waters. Large-scale industry partnerships aren't unheard of i...Lake research offers clues to managing crayfish invasions
...lm their predators by producing more offspring and destroying the plant life that protects fish. "That these alternate states exist gives us some hope that we might be able to take lakes infested by rusty crayfish and force the system from one state to another," says Roth. To test this theory, he and other res...Researchers look into components of RNA silencing machinery
...A silencing machinery silences gene expression, by destroying RNA, a molecule that carries out DNA's instructions. Two years ago, components of the RNA silencing machinery were shown to be absolutely required for forming heterochromatin, a chromatin state that silences DNA, suggesting a new rule in biology. But...Gene defects found in age-related macular degeneration
... center of the retina, compromising and ultimately destroying its function. For the study published in NEJM , the researchers recruited 402 people with AMD and 429 healthy subjects. They obtained blood samples from the study subjects, which they used to extract DNA that was then examined for variations in gene...JCI Table of Contents, 15 July 2004
... but instead interferes with osteoclasts, the bone destroying cells. The work here provides a detailed examination of the molecular underpinnings involved in ritonavir's inhibition of bone resorption, showing that it works by inhibiting a key element in osteoclast development and function, the function of a re...Study suggests first molecular target to halt spread of HPV
..., templates. Clawson and his team supposed that by destroying RNAs used for production of E6 and E7 proteins, the virus would no longer be able to trigger cellular proliferation. "There are some unique characteristics of E6 and E7 which make them good targets, most importantly, their critical role in overcomin...Common worm provides insights into salmonella virulence
...ate immune system of C. elegans from attacking and destroying the infecting bacteria. These findings are important, the researchers said, because the C. elegans innate immune response to Salmonella infection is quite similar to that of mammals, including humans. For this reason, the researchers said that their ...Protein may reduce susceptibility to autoimmune disease
...s that normally protect the body from infection by destroying cancer cells and cells infected with dangerous bacteria or viruses. However, overactivation of T cells can lead to an assault on the body's own healthy tissues, leading to some form of autoimmune disease. The protein cytotoxic T lymphocyte-associat...New insight into how tumors resist radiation
...enhanced the effectiveness of radiation therapy by destroying tumor blood vessels without having an impact on normal vessels. These results indicate that HIF-1 acts as a major factor directing resistance of tumor vasculature to radiation therapy. According to Dr. Dewhirst, "We believe that by understanding how ...New research supports theory that indirect transmission of chronic wasting disease
... aberrant prion protein that misfolds inthe brain, destroying brain tissues as it progresses. Clinicalsigns include lethargy, excessive salivation, loss of wariness ofpredators and slowly deteriorating body condition. The disease isalways fatal and there is no known cure or treatment to preventCWD. Federal and...Sediments in many Central Valley streams contain toxic levels of pyrethroid pesticides
...t want to give the impression that pyrethroids are destroying the streams, since that has not yet been shown, but if we are serious about maintaining stream health, we have to consider the sediments and not limit our sampling just to the water above," said Weston. "While pyrethroids may be preferable to the org...Traditional fishing destroys corals - new research
Traditional fishing techniques are destroying some of the world's finest coral reefs, according to new research which has major implications for international marine conversation management strategies. Until now commercial fishing was believed to pose the greatest risk to reefs, which are found ...ORNL's nanobiosensor technology gives new access to living cells molecular processes
...s to physically probe inside a living cell without destroying it. As scientists adopt a systems approach to stud... can be inserted into a cell and withdrawn without destroying it. Because the 40-nm diameter of the fiber-optic probe is much narrower than the 400-nm wavelength......for nesting sites by evicting other nesting birds, destroying their eggs, killing nestlings and sometimes even killing the incubating female. Adding to the competition is the fact that once a male house sparrow establishes a territory, he remains there year-round and starts defending that territory early in the...