Defining a niche that regulates stem cells
...gress of the progeny of the marked stem cell, they detected a rapid replacement of the marked cell with "wild-type" stem cells in the niche. "This showed us that a cell can move into that spot and function as a stem cell," said Spradling. The researchers took advantage of a special structure within the stem...Brown researchers use wildcards to develop better way to sequence DNA
...ys pairs with C). Then the DNA can be detected and read. Using the information obtained from the probes on the microarray, a computer program is then used to construct the long sequence of bases in the target DNA strand. Current techniques can construct only a few hundre...Studies at UNC plumb tumor resistance to treatment
...patented, tumor cells bound to the chemical can be detected by a laboratory immunoassay. Essentially, the test identifies the antibodies, which serve as markers for hypoxic cells. In Boston, MA, October 23, at the annual meeting of the American Society for Therapeutic Radiology and Oncology, Varia will pre...Researchers identify molecule that senses osmotic pressure in vertebrates
...cken and human gene libraries. The ion channel was detected in cells from the inner ear, the osmoregulator centers of the brain in the hypothalamus and from cells surrounding whiskers, a rodent's snout hair known to be very sensitive to touch. The presence of VR-OAC in the latter cells suggests that this rec...Worldwide transfer of microorganism facilitated by ballast water
... bacterium that causes human epidemic cholera, was detected in all ships tested, and included the recently emerged serotype 0139, which was recently isolated in Bangladesh. While V. cholerae and other potential pathogens are normal constituents of coastal waters in the U.S., they do not ordinarily occur in h...Target cells found to play active role in synapse formation
...l muscle membranes from Drosophila, UI researchers detected similar axon-like fingers. Filopodia extending from axons - the communicating arms of neurons - are well documented and thought to be the reaching, seeking fingers that latch on to the receptors of target cells such as muscles. In the October iss...American Society for Microbiology news tips for November 2000
... the surfaces and internal structures of apples as detected by confocal scanning laser microscopy. Applied and Environmental Microbiology, 66: 4679-4687.)......ly stage of glutamate synapse development. They detected enhanced clustering and activity of glutamate synapse development, enhanced clustering and activity of glutamate receptors at the post-synaptic sites and an increase in the number and size of dendritic spines, which contain the receptors that respo...Diagnosis on a chip - molecular profiling that could improve diagnosis and help design better drugs
...that allow hundreds to thousands of proteins to be detected and measured at once to sort out and measure the concentrations of specific proteins and antibodies in complex solutions such as blood samples. In an article posted in advance of publication in GenomeBiologys preprint depository, the research team ...Discovery may jump-start mine remediation efforts
... discovered microstructural characteristics can be detected in ancient zinc sulfide deposits. This will be important for making the case for the biogenicity of these ores."...Scientists perform whole-genome, whole-brain study of Down syndrome
...isomy mice to that of normal mice. The scientists detected an estimated 25,000 genes active in the mouse brain, 330 of which altered between trisomy and normal mice. In particular, the researchers found that a number of "ribosomal protein" genes, involved in manufacturing the cell's proteins, were less acti...Three genetic steps convert normal mammary cells into breast cancer cells
...nsplanted into mice. In addition, the researchers detected in the artificially transformed cells amplifications of the c-myc oncogene, another gene that is frequently mutated in breast cancer. Therefore, this in vitro transformation protocol did not only produce malignant mammary cells, but did also initiat...Saving Florida's gentle giants
...ring the first five weeks of operation, the system detected seven manatees and saved them. Historically, the only way to prevent manatee accidents at the Florida's gates had been to spot them visually - difficult to do in murky waters - and manually hold the gates open until they passed. Using the technology...Genomics research promises to make hogs less piggy
...ressive behavior in chickens. In that research, he detected that competition for food had a significant effect on animal survival and production. Through that work, he discovered major genes for behavior in vertebrates. "These genes arent used in hog breeding programs," Muir says. "They are concerned about b...Scientists see early indications of lobster decline
...he Boothbay monitoring region. Similar trends were detected in larvae in New Hampshire and new settlers in Rhode Island. The larvae and settlement studies suggest widespread declines at least west of Penobscot Bay. No larval monitoring has been done east of there. Censuses of juvenile lobsters that are two ......iploid cells to drug resistance were too low to be detected under the conditions used. Duesberg, Stindl and Hehlmann found that cells with highly abnormal chromosome numbers have a one to two percent chance of gaining or losing a chromosome each time they divide. In a colony of a million cells, that provides ...Drug decreases blood vessel stiffness in older primates
... body weight or routine chemical measurements were detected during the follow-up period. The finding was published in the January 30, 2001 issue of Proceedings of the National Academy of Sciences. Arterial stiffening is a major factor in many of the vascular diseases associated with advancing age, said E...Tips from the journals of the American Society for Microbiology: February 2001
...s was the first time that mycobacteriosis had been detected in the Chesapeake Bay and represents the first reported case of mycobacteriosis in wild fish on the Atlantic coast," say the researchers, who have isolated the bacterium responsible and suggest that it is a new species of mycobacterium, the family of......pidly between species." Previous studies had only detected rapid evolutionary change in male reproductive pro...rm/egg incompatibilities might occur that could be detected by sequence-based tests." Moreover, the subtle but significant changes in signaling proteins of sper......of trouble; it's an early warning sign that can be detected only with an EKG," according to Raymond Woosley, MD, PhD, associate dean for clinical research at Georgetown University Medical Center and principal investigator of the study. "After the prolonged QT interval has developed, it can lead to an abnorma...