Chemical derived from vitamin-E shows early promise as cancer drug
... Using this fluorescent cue, Kline and colleagues determined that mice treated with aerosolized alpha-TEA had less than half the number of lung micrometastases as untreated mice (an average of 31 versus 73 detected cancer cells or small clusters of such cells). In addition, 48 percent of nearby lymph nodes of ...Researchers identify protein promoting vascular tumor growth
...lopment, Ohio State University medical researchers determined that a protein called MCP-1 "recruits" macrophages...titute investigators Chandan Sen and Sashwati Roy, determined MCP-1's role in recruiting macrophages by observing tumor responses to an MCP-1 neutralizing antibod...DNA barcode finds four new bird species
...species identification. "New species won't be determined by DNA analysis alone," says Stoeckle. "Morphology, behavior, and vocalization, for example, will still need to be accounted for in determining whether something is a species. But barcoding will enable rapid screening of large numbers of organisms an...Bullish chemical could repel yellow fever mosquitoes
...wn as bovinic acid. In doing so, the chemists also determined the exact chemical structure of the compound. Their approach is described in this week's Angewandte Chemie , a German chemistry journal. The World Health Organization estimates that yellow fever kills 30,000 people every year, primarily in sub-Sahar...Study explores gene transfer to modify underlying course of Alzheimer's disease
...zynski at the University of California, San Diego, determined that there were no adverse effects from NGF detected in the subjects, an indication that the biological therapy is itself safe and well tolerated. Since the study was small and did not include placebo controls, apparent trends toward improvements in...$2.7 million grant to support creation of virtual zebrafish atlas
...will show zebrafish microanatomy at magnifications determined by the user, and will provide three-dimensional images of body structures such as organs. "There has been phenomenal growth in the zebrafish research community due to the zebrafish's compelling experimental characteristics and its capacity to model ...New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...lecular link between inflammation and cancer. They determined that an enzyme called I-kappa-B kinase beta (IKKβ) is required for the activation of NF-kB, which acts as a master switch to turn on inflammation in response to bacterial or viral infections. In turn, NF-kB sets off a chain of reactions that lea...US investment firm gives away Rhode Island-sized lands in Chile
...rch process, the Goldman Sachs Charitable Fund has determined that WCS is ideally suited to create a reserve and protect the key ecological features of this land for the people of Chile. The transfer represents one of the most significant gifts of private land worldwide, due to the size of the land (approximate...NSF announces six 'FIBR' awards to tackle some of biology's most challenging questions
...l Roles," examining how much of social behavior is determined by genes and how much is influenced by the environment -- University of Illinois, Urbana-Champaign "Ecological Genomics and Heritability: Consequences of Extended Phenotypes," studying the genetic forces that draw together members of an ecological c...Spontaneous mutation produces new MAO A/B knockout mouse
...ress." Looking further into the matter, Dr. Shih determined that a spontaneous mutation in a single nucleic acid base pair in the MAO A gene created a premature stop which prevented it from being made into a protein. The scientists hypothesize that the mutation was due to elevated levels of the MAO B substra...Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
.... Recently, utilizing an animal model of IBD, they determined that growth hormone itself is able to directly reduce inflammation in the diseased intestine, as well as promoting growth. In the long run, "this may lead to new therapeutic approaches which will take advantage of these properties in both improving ...Cell's gatekeeper for ammonia revealed in unprecedented detail
...cture -- depicted on the cover of Science -- was determined in greater detail than that of any cell membrane c...said. Using X-ray crystallography, the researchers determined the channel's structure down to an unprecedented resolution of 1.35 angstroms, or just over a 100-mi...Researchers discover why mutant gene causes colon cancer
...ted mutation is 100 percent. Scientists have since determined that an acquired mutation of the APC gene is also found in 85 percent of sporadic colon cancer. Colon cancer is the number two cancer killer in the United States....Sandia experiments may reduce possibility of future water wars
...quality of the hydroponically grown plants will be determined by Clint Loest, a professor of animal nutrition at New Mexico State University, whose lab will compare results of feed testing with the animals' actual requirements. "This is definitely unique in the animal forage area," he said. "If we can...Common cold virus can cause polio in mice when injected into muscles
... symptoms characteristic of polio. The researchers determined that administering the virus directly into muscles, instead of the virus's normal home in the nasal cavity, was critical for development of polio. The findings challenge traditional views as to what defines a poliovirus, said Matthias Gromeier, M.D.,......ELES, SEPT. 2, 2004--The shapes of avian beaks are determined by areas of active growth amidst areas of slow growth in a developing embryo, and are associated with activity levels of a specific protein called bone morphogenetic protein 4 (BMP4), according to a group of researchers from the Keck School of Medici...Scientists discover proteins involved in spread of HIV-1 infection
...it for its own purposes. Previously, scientists determined that the yeast version of TSG101, called Vps23p, binds to two other proteins, Vps28p and Vps37p, to form the E ndosomal S orting C omplex R equired for T ransport (ESCRT-I) which then participates in the protein sorting and packaging process. H...Analysis of biological clock may lead to greater understanding of human disease
...de-off between robustness and fragility is largely determined by the architecture of the regulatory system, and that the design for precision at keeping accurate time may be at the expense of the fragility of the global machinery. They also discovered that sensitivity analysis confirms the theoretical insight t...Environmental costs of home construction lower with wise choice, reuse of building materials
... a life-cycle assessment. In this case researchers determined that the construction of a hypothetical Minneapolis steel-frame home used 17 percent more energy than the matching wood-frame home. Constructing the study's hypothetical Atlanta concrete-frame home used 16 percent more energy than a matching wood-fra...University of Pittsburgh receives $10 million grant for head and neck cancer
...ene, cyclin D1, that previous research at UPCI has determined are significant predictors of head and neck cancer risk, as well as increased risk for lung cancer in smokers. The researchers will examine the interaction of these genes with the goal of identifying individuals who have an increased likelihood of de...