Study points to a promising new test for myelodysplasia, a blood disorder often leading to leukemia
... 29th describes a promising new test for the early diagnosis of a serious blood disorder that can lead to bone marrow failure and acute myelogenous leukemia. Myelodysplastic syndrome (MDS), diagnosed in about 15,000 to 20,000 people a year, occurs mainly in patients over 60 years of age. Those who do not dev...Fox Chase Cancer Center research reveals how COX-2 causes ovarian cancer
... of markers of the disease that will be useful for diagnosis and for assessing treatment results. One of the r...ate among women who develop ovarian cancer is that diagnosis often is delayed until late stages of the disease. In addition to Xu and Daly, the Fox Chase researc...Researchers identify a new form of disease gene associated with Rett syndrome
...a new molecular test that will aid not only in the diagnosis of Rett syndrome, but also for other developmental...drome genetic tests are used not only to confirm a diagnosis of Rett syndrome, but also for 'negative inclusion' in other developmental disabilities such as cere...Researchers discover an alternate form for the disease gene associated with Rett syndrome
...to a new molecular test that will aid not only the diagnosis of Rett syndrome, but also for other developmental disabilities. This research is reported in the April issue of the journal Nature Genetics (available online March 21, 2004). "The previously identified gene MECP2 was only found in approximately 80% ...Researchers confirm novel form of the Rett syndrome protein
... "Currently about 15 % of patients with a clinical diagnosis of RTT are testing negative for mutations in the MECP2 gene. This development may help to further identify mutations in exon 1. Incorporation of this clinical testing will be of importance to affected families and may provide scientific insight," sta...Cross-species comparison reveals shared features between tumorigenesis and organogenesis
...t can be developed as a useful tool for both tumor diagnosis and prognosis. Indeed, the investigators show th...clinically meaningful insights such as advances in diagnosis or our understanding of tumor behavior," Kohane said. "This study provides a foundation to ask thes...Combination therapy drives cancer into remission
...eatment decisions are best guided by the molecular diagnosis of which gene products are hyperactive or inactive in a particular tumor. Moreover, the study indicates that existing drugs believed to be ineffective against a particular class of cancer can in fact be used with success through rational, personalize...New, comprehensive tumor classification combines molecular biology and classic pathology
...m virtually every clinical decision related to the diagnosis and treatment of patients with cancer. Both the type of cells from which a tumor is derived and the molecular characteristics of those cells determine how a tumor will behave information of great importance to clinicians. Berman has organized his cl...Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon
...ent's immune system rejects the new implant. Early diagnosis and treatment of organ rejection is critical. Center investigators are developing novel, non-invasive MRI-based methods to monitor organ function and the accumulation of immune cells at a transplanted organ. One of the center's primary goals is to es...Children's Memorial, TGen announce partnership
...ndrix said. "Our hope is to provide new methods of diagnosis and treatment, leading to individualized medicine for patients." Hendrix, who took over the reins at Children's Memorial's research institute in January, is an internationally respected cancer researcher whose work includes the molecular classificati...New test detects cirrhosis of the liver in an early stage
...ction. Often, 10 years can pass between the first diagnosis and the development of cirrhosis of the liver. An annual test could quickly detect a change and be able to predict an early stage of cirrhosis. Nico Callewaert comments: 'We hope to be able to alert patients when the chance of liver cancer increase...Common virus may contribute to uncommon bone disease in children
...udy. The research may eventually lead to an easier diagnosis and to more effective treatments of the disease, Langerhans cell histiocytosis. Researchers found evidence of the virus, human herpesvirus 6 (HHV-6) in the tissues of 25 of 35 children with Langerhans cell histiocytosis (LCH), compared to virus detec...Other highlights in the March 3 issue of JNCI
...y that SELDI-TOF will be a useful approach for the diagnosis of cancer. He identifies artifacts that could bias data obtained using this technology and he suggests that the technique may identify molecules whose serum concentrations vary considerably because of factors such as acute or chronic inflammatory con...New imaging technique developed to identify breast cancer
...utine MRI scan that may aid physicians in making a diagnosis of breast cancer," says Jacobs. "We can envision a time when this procedure may even replace the need for biopsy in some cases and provide the basis to follow treatment strategies in certain cases of breast cancer. However, more research is needed to...ORNL earns four Federal Laboratory Consortium awards
...icrocantilever-based biosensors can be used in the diagnosis of disease, cancer and cardiac markers, high throughput drug screening and exposure to chemical and bio-warfare agents. Researchers from ORNL working on this project are Thomas Thundat, Zhiyu (Jerry) Hu and Russ Miller. The lab-on a-chip is a microfa...Teens and young adults the new frontier in cancer says US cancer specialist
...meant patients may be at a higher risk for delayed diagnosis and this may impact on survival. One study found that for all solid tumours except Hodgkin's disease, as age increased lag time increased. Adolescents and young adults feel they are invincible and tended to give poor information, especially to doc...International critical care doctors release first-ever guidelines for sepsis
...heir colleagues: More aggressive recognition and diagnosis of sepsis in all hospital departments Monitoring of central venous oxygen saturation levels Empiric, timely antibiotic therapy to fight the underlying infection Maintenance of adequate blood pressure through IV fluids and/or medications When loca...Double mastectomies significantly lower risk of breast cancer in women who are genetically at risk
...ne of the participants had any previous or current diagnosis of cancer upon entering the study. Breast cancer was diagnosed in two of 105 women (1.9 percent) who had double mastectomies. The occurrence of breast cancer was much greater in the control group, with 184 of 378 women (48.7 percent) developing ...UC San Diego faculty receive funding from von Liebig Center to commercialize academic research
...al and pathological conditions, especially for the diagnosis of diseases such as cancer. Kinases play a crucial role in a variety of cellular processes, including cell division, angiogenesis, motility, and adhesion. Chien and Wang have developed a biosensor capable of detecting kinase activity in live cells b......or celiac disease. The researchers also looked for diagnosis of similar digestive disorders not previously associated with schizophrenia, which included dermatitis herpetiformis, Crohn's disease and ulcerative colitis.The researchers found a small number of schizophrenic patients were previously treated for ce...