Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
...hose computer screen saver is a colorful molecular diagram of a tyrosine kinase called the platelet-derived growth factor receptor. Paez works with tumor specimens, frozen in liquid nitrogen, that come from the DFCI tissue bank or from collaborators at other facilities. Paez extracts the DNA and singles out ...Leptin rewires the brain's feeding circuits
...l, these findings begin to suggest that the wiring diagram of the feeding circuit is highly dynamic," said Fr...ad us to at least ask to what extent is the wiring diagram of these neural circuits different in obese people relative to lean people. "If we knew that the bas...Building the whole cell from pieces
...s, the researchers were sometimes able to obtain a diagram for a machine. "This gave us a way of bridging the resolution gap between fuzzy pictures of cell machines and more detailed atomic pictures of their individual parts," Aloy comments. "Once we have an assembly plan for an individual machine, we know ...Whats next as biology, math combine forces, reciprocate in discovery
ARLINGTON, Va.--As if caught in some Venn diagram whose intersection just keeps growing, mathematics and biology are increasingly commingled in efforts yielding discoveries. Joel E. Cohen, director of the Laboratory of Populations at Rockefeller University, will examine the convergence Thursday, Ju...Gene enhances prefrontal function at a price
...orresponding to the top of an upside-down "U" (see diagram below). "The combined effects on dopamine levels of amphetamine and high working memory load push individuals with the met/met genotype beyond the critical threshold at which compensation can be made," suggest the researchers. They note evidence fro...Researchers unwind secrets of biological clocks
...s in people, Golden said, revealing the structural diagram is a very important step to learning how the clocks actually work. It was no small trick to produce a model from a one-celled organism so simple that no one can even see just how it acts out its daily rhythms of life. The organism doesnt even have a...UCSD bioengineers develop first computer model that predicts disease variant based on genetic defect
...an red blood cell. "The model is like the wiring diagram or design drawings for the cell," says Palsson. "It incorporates all the genes in the cell, the products of each, and the interwoven process of how those products interact to produce cellular functions. Once we have this computer (now called in sil...Researchers characterize a crucial family of signaling proteins in the human genome
... for protein kinases, they constructed a tree-like diagram known as a phenogram, which maps the relationship between different protein kinases based on the differences in their sequence. This phenogram shows that there are five distinct protein kinase families, a result that is consistent with classification...Virginia Tech researchers receive $450,000 award to model cell division
...arts list of the cell, scientists need a schematic diagram of how all those parts hook together," Tyson said. "From the schematic diagram, we can write equations that govern the behavior of the control system, much like an electrical engineer can write equations for a circuit diagram. With these equations we...Study to help solve health problems by understanding gene, protein behavior in cells
...his information, we have to reconstruct the wiring diagram of the cells control circuitssomething like the wiring diagram for a VCR, only much more complicated. The challenge is to figure out how the cell works, so we can...Clamping down on a cancer-causing protein
...lar Biology Laboratory (EMBL) have produced such a diagram of a cancer-causing molecule, and their work gives researchers a good idea of how to go about designing drugs. Their report appears in the current issue of the journal Cell. The molecule, a protein called Abl, is produced in all human cells. Some peo...Study helps identify key step in simple motor learning
...g," explains Linden. "Now we're using that wiring diagram to look at the details." Linden is studying strange, sea-fan-shaped brain cell called Purkinje cells (pronounced per-KIN-jee). These odd cells are found only in the cerebellum, a part of the brain involved in coordinating and learning muscle movement...Researchers build diagram of cell cycle clock
...le, which tells cells when to divide. This network diagram describes the genetic switches and connections that form the circuit common to a process found in all living organisms, from bacteria to human beings. The findings were published in the September 21 issue of Cell by Whitehead Member Richard Young and...Mouse gene trap helps decipher brain's wiring diagram
...(NIMH) have perfected a way to discover the wiring diagram of the mammalian brain. The technique, a type of gene trap, provides a shortcut for identifying - from among the tangled trillions of neural connections -- just the machinery involved in wiring up the brain during early development. NIMH grantee Ma...DNA arrays decipher genome's master switches
... complicated machinery of life. Creating such a diagram represents the next step toward using the information from the Human Genome Project. For although the Human Genome Project will soon provide researchers a catalog of all the genes that make up a human being, it will in many ways be analogous to havin...Scientists map first structure in important family of proteins
...nvolved in sorting through 50 gigabytes of data to diagram the position of 348 amino acids in the crystal's structure. The title of the article is "Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor." Besides Palczewski, Stenkamp, Okada and Miyano, the authors include Takashi Kumasaka, Tetsuya Ho...Food web theory suggests ecology may be governed by general rules
...he researchers to create a three-dimensional color diagram of each of the food webs, showing in visual form their basic properties, such as links between species (in the form of a line between species, which are represented by balls colored to correspond to their respective trophic level) and cannibalism (re...Uncovering structure of cellular switch could aid design of cancer-fighting drugs
...ng them with intense bursts of X-rays. A "ribbon" diagram of the Cdc42/GDI complex is printed on the cover of the journal. Co-authors of the report, along with Cerione, are Gregory R. Hoffman, a Cornell graduate student in biophysics, and Nicolas Nassar, a postdoctoral associate. The mammalian Cdc42 protei...Gene Mutation Found For Common Form Of Mental Retardation
...Program. Editors: A color and a black and white diagram are available upon request fromHarvard Medical School. Contact: Harvard Medical School Bill Schaller, (617) 432-0441 schaller@hms.harvard.edu Misia Landau, (617) 432-2342 landau@warren.med.harvard.edu ......tries around the world. NOTE TO EDITORS: Photo and diagram available....