16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
...rved in later stages of muscle cell commitment and differentiation and are likely to be involved in maintaining muscle side population cells in an undifferentiated state and available on demand for muscle regeneration. 13.4 Bente Klarlund Pedersen (University of Copenhagen, Denmark) The biological role of the myo...JCI table of contents September 15, 2004
... bacterial DNAinduced IL-12 production and Th cell differentiation AUTHOR CONTACT: Tetsuya Matsuguchi Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan Phone: 81-99-275-6130; Fax: 81-99-275-6138; E-mail: tmatsugu@denta.hal.kagoshima-u.ac.jp View the ...Tufts University establishes $4 million dollar tissue engineering resource center
...ology and the impact of these factors on stem cell differentiation toward specific tissue types, such as bone, cartilage and myocardial tissues. The Center laboratories will offer researchers from the U.S. and around the world full access to the latest techniques to solve complex challenges in the field. It wi...Analysis of gene expression in lymphoid cells can determine lymphoma cancer
... "CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation," appears in the Jour...ress this protein, we are able to promote myogenic differentiation by enhancing the myoD function," says Giordano, who also discovered the tumor suppressing gene Rb2/p...APS awards more than $140,000 to minority students of physiology
...scovered that activation of Wnt signaling inhibits differentiation of fat cells and prevents obesity in mice. Currently, she is testing whether Wnt signaling results in fewer fat cells and more bone forming cells in the marrow cavity. This work may provide a new target for preventing the bone loss associated with a...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
...chers conclude that "embryonic stem cells, through differentiation within the host myocardium, can contribute to a stable beneficial outcome on contractile function and ventricular remodeling in the infarcted heart." Going a step further, they add that "the stable benefit of embryonic stem cell therapy on myocardial...JCI table of contents, 16 August, 2004
...tion of NFAT family and RANKL-regulated osteoclast differentiation AUTHOR CONTACT: Riko Nishimura Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan Phone: 81-6-6879-2887; Fax: 81-6-6879-2890; E-mail: rikonisi@dent.osaka-u.ac.jp View the PDF of this article at: https://...Protective gene may enhance vaccine responses
...now a great deal about the rapid proliferation and differentiation of these T cells but very little about the factors that regulate contraction. In the September, 2004, issue of Nature Immunology published on-line August 15 -- the researchers show that activation of the gene for the Serine protease inhibitor 2A (S...Joslin Diabetes Center launches research section on developmental and stem cell biology
...ific genes needed to prevent cell death and induce differentiation at the very earliest stages of embryonic development. Her laboratory has shown that pathways activated by excess glucose metabolism are responsible for the effects of diabetes on embryo gene expression. Embryonic stem cells can be used to study the p...JCI table of contents, 2 August, 2004
...ion TITLE: Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1 AUTHOR CONTACT: Daniel I. Simon Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA Phone: 617-525-4371; Fax: 617-525-4377; E-mail: dsimon@rics.bwh.harvard.edu View the PDF of this ar...Good bacteria trigger proteins to protect the gut
...rved a generalized disruption in proliferation and differentiation of intestinal epithelial cells in the MyD88-deficient mice, implicating TLRs in overall maintenance of the tissue. The animals' intestines were particularly sensitive to radiation, which could be attributed in part to the unusually rapid cell divisio...A pathway to blocking autoimmunity
...to how signals from outside the cell can influence differentiation and gene expression and is an entry point for intervention into autoimmunity by modulating CD1d expression, and NKT cell activation. "We think PPAR-gamma is capable of orchestrating a coordinated response whether endogenous ligands arrive from outsid...Cell study leap forward for tissue engineering, diseases
..., have found that the mechanism that controls cell differentiation is the same one that controls tissue elongation. The finding, published in the July 15 issue of Nature, provides insight into the intricacies of "morphogenesis", a crucial step in embryonic development through which cells and tissues form into differ...Mouse brain stem cells capable of converting into blood vessel cells
...stem cells in the brains of mice possess a broader differentiation potential than previously thought and may be capable of developing into other cell types including those involved in the formation of new blood vessels, according to a new study supported by the National Institute on Aging (NIA), a part of the Nation...Scientists discover key step in the development of nerve cells controlling autonomic functions
...ation of crucial mechanisms controlling nerve cell differentiation and uncovered new protein functions during neurogenesis. The ultimate goal of his research program is to provide strategies to manipulate multipotent neural progenitor/stem cells and facilitate the design of approaches that may promote the repair of ...Sequential signals choreograph embryonic tubule formation
...atrix metalloproteases (MMPs) are required for the differentiation stage but not the initial migration phase." The researchers conclude that HGF directs the complex process of tubule development by dividing it into two distinct phases that are controlled by different molecular signals provided by ERK and MMPs. Accor...Macrophages, not stem cells, correct liver disease by fusion
...er cells were corrected by cell fusion rather than differentiation of the transplanted stem cells. "Various labs have reported that bone marrow or blood stem cells are like super cells. They can turn into anything liver, lung, brain, muscle," Grompe said. "Our thought was that blood stem cells are really there to r...JCI table of contents, 1 July 2004
...ion at an apparently critical time during cellular differentiation explains why this disease occurs even in the prese...-copy expression of the FLI1 gene effects cellular differentiation and leads to the disease state in Paris-Trousseau/Jacobsen thrombopenia. TITLE: FLI1 monoallelic exp...Innovative efforts target epigenetics, molecular imaging
...for studying basic biological processes, including differentiation of neural cells, alternative splicing of RNA in mammalian cells and asymmetric cell division in mammalian stem cells. To do so, it will collaborate with investigators at other institutions, including: Washington University in St. Louis, where one gro...Kaposi's sarcoma virus 'reprograms' blood vessel cells into lymphatic cells
...ng a major role in controlling the development and differentiation of lymphatic vessels and found that aberrant expression of Prox1 in mature blood-vessel-lining cells can reprogram them to develop into lymphatic-lining cells. Because the KS virus can infect blood vessel lining, the research team decided to investi...