Tag: "disable" at biology news

Collaboration advances potential therapy for autoimmune diseases

...ed them. Antibodies are proteins that bind to and disable foreign proteins, called antigens. With fully humanized antibodies, the human body potentially could accept them over longer periods of time, thus providing for long-term treatment. The Russian research, coupled with a treatment method developed by...

New gene discovered for male fertility in plants

...ied this gene and its function, plant breeders can disable it with more stable methods that do not involve using genes that can jump around," he says. One advantage of male-sterile plants is in the production of hybrid varieties of some species that currently are difficult and expensive to produce in quant...

New mouse model shows how news of pathogen reaches immune system

...ink it is, then it's likely that some bacteria can disable this mechanism. "We should be on the lookout for bugs that throw a spin in the works and prevent this dialogue from happening," Ploegh said. "It's a recurring theme of host-pathogen interactions: Every move by the immune system is counteracted by a ...

Experimental 'gene switch' increases lifespan with no ill effects

... Perhaps evolved as a viral strategy to attack and disable hosts, RNA interference, or RNAi as it is called, .... In some experiments, they used RNAi to partially disable daf-2 activity; in others, they inhibited a gene called daf-16, which Kenyon's group had previously ...

Checkpoint protein blocks chromosome breaks at fragile sites

...r used three different techniques to inactivate or disable ATR expression in human cell cultures used in the U-M study. To put cells under stress, she treated the cell cultures with aphidicolin, a substance that makes it harder for cells to make new DNA. Casper discovered that fragile site breaks were 5- to ...

UCSF study of ancient fly gene offers insights into male fertility

... says Xu, that drugs could be developed that would disable BOULE in the testes and thus block the progression of meiosis in developing sperm. After being administered for several months the period of time it would take for the mature sperm in the testes to proceed through the natural cycle to death the dru...

Receptor could be target for cancer therapy

...ing power of the host immune system; in part, they disable the immune response. New studies from a group of Vanderbilt University Medical Center investigators implicate a receptor for prostaglandin E2 (PGE2) in this phenomenon of tumor-induced immune suppression. The findings, published in the March 1 Jour...

Microgel polymer beads may provide general vehicle for vaccines, gene therapy

...ctually causing the disease. The easiest way is to disable a virus with chemicals or heat so that it can still invade cells and carry in antigens, yet not reproduce. The polio, smallpox and influenza vaccines are like this. Other approaches include encapsulating viral or cancer antigen proteins in other mat...

Researchers discover common cause for aging and age-related disease

...que called RNA interference, or RNAi, to partially disable the small heat-shock protein genes. They showed that the heat-shock proteins account for a substantial part of the worms' increased life-span. (In a related study, researchers at the Buck Institute for Aging led by Gordon Lithgow have recently shown ...

Virus researchers close in on the secret life of DNA

...rotein (one known to be necessary for the virus to disable animal cell defenses) works by binding to Z-DNA an...ns to E3L's active site had earlier been proved to disable the virus. They also found that non-lethal forms of the virus containing a similar protein that does...

Newly mapped enzyme could yield new treatments for female sexual dysfunction

...nal structure, easing the job of creating drugs to disable it. Their results will appear in the Aug. 5 issue of the journal Biochemistry, and were published this week on the journal's Web site. "Existing treatments have shown little success in treating female sexual dysfunction," said lead author David W. C...

Monitoring malaria: Genomic activity of the parasite in human blood cells

...ial drugs. To develop new drugs and vaccines that disable the parasite, researchers need a better understanding of the regulatory mechanisms that drive the malarial life cycle. In an article that will appear in the inaugural issue of PLoS Biology (and currently available online at (http://www.plos.org/down...

Small subset of cells has big role in controlling immunity, study finds

...ence that the developing fetus uses IDO to locally disable the mother's immune system. It works by degrading tryptophan, an amino acid critical to the survival of T-cells, which get their action cues from dendritic cells. The MCG scientists have focused many of their efforts since on how to use the IDO mec...

Proteins enable HIV to override cell's defenses

...cell's natural antiviral agent called APOBEC3G. To disable the antiviral agent, Vif interacts with a series of proteins to modify (polyubiquitination) and degrade APOBEC3G. Xiao-Fang Yu, MD, DSc, an associate professor with the School's Department of Molecular Microbiology and Immunology, and his colleagues ...

UCSD, VA and Cal-(IT) wireless technology to enhance mass casualty treatment in disasters

...hen the Russian government used a gaseous agent to disable the terrorists, more than 100 of their hostages died. Medical personnel later reported that most deaths were due to lack of vital signs monitoring at the scene and an inability to organize care to determine who was breathing and who wasn't. Lenert n...

Study explores safety of low-dose radiation

...n cancer cells that you can increase the damage or disable the repair mechanism for these double-strand breaks so that you get better cell kill." Dr. Barrett theorizes that the repair/protective mechanisms are generally adequate since most people get regular exposure from everything from cosmic rays to some...

Scientists report on promising new approaches to induce cancer cell suicide

... scientists used a fragment of genetic material to disable a protein used by many tumor types as an "off switch" to prevent cell death, triggering cancer cell suicide. A third study focused on a novel inhibitor to improve responses to central nervous system tumor therapy. The findings were presented today a...

Parasite's enzyme structure helps address a public health issue

... it works," says Anderson. "Then we'll know how to disable it and kill the parasite." Anderson, along with Robert O'Neil, a senior researcher and the lead author of the study, Ryan Lilien, an M.D./Ph.D. graduate student at Dartmouth, Bruce Donald, Professor of Computer Science, and Robert Stroud, Biochemis...

Gene-disabling techniques simplified by Stanford team

...mes the first step to learning a gene's role is to disable it and see what happens. Now researchers at the St...eating a handful of siRNA molecules to genetically disable three known genes. In each case, their technique generated siRNA that effectively blocked the gene i...

Genetic screening recommended to detect new neurodegenerative disorder in men over age 50

...s, and whether other therapies, such as surgery to disable nerve tracks, may actually exacerbate balance problems. Hagerman, a developmental and behavioral pediatrician who has specialized in the diagnosis, research and treatment of fragile X for more than 20 years, began looking for a connection between ch...

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