Tag: "disabled" at biology news

Researchers ID chlorophyll-regulating gene

... a plant's growth and development. The researchers disabled the PIF1 gene in the species Arabidopsis thaliana, a mustard plant, and compared the mutant seedlings with a control group of normal plants. They grew the seedlings in the dark to mimic conditions beneath the soil, bringing groups out into the ...

Firefly compound lights up 'protein dance' in living animals

...ng the two proteins to interact. In mutations that disabled rapamycin's ability to bind to the target protein, scientists detected no light even after rapamycin injections. According to Piwnica-Worms, the series of experiments proved the accuracy and selectivity of the new luciferase-based approach. Scientist...

New insight into cancer metastasis

..., Yang isolated highly metastatic cancer cells and disabled the Twist gene. When she injected these cells into mammary glands of mice, the mice developed primary, localized breast tumors--but the tumors were unable to metastasize. Furthermore, their study showed that Twist caused breast cells to separate from...

Brain development and puberty may be key factors in learning disorders

...ould help explain anecdotal evidence that learning disabled children toilet train late, have difficulty learning to ride a bicycle, talk later and generally appear less developmentally mature than their unaffected counterparts. The Northwestern researchers found that the brains of individuals with learning...

How genes get us wired

...he brain-to-face circuit. When the researchers disabled the Hoxb1 gene in the face but not in the brain of...out mice," which are mice in which a gene has been disabled or knocked out so scientists can see what goes wrong without the gene and thus learn the gene's norm...

JCI table of contents, 2 April 2004

... selective macrophage depletion in sutured corneas disabled corneal angiogenesis. These findings demonstrate critical roles for VEGF-A and for macrophages in the pathological induction of both hemangiogenesis and lymphangiogenesis and identify important targets for antiangiogenic therapies. TITLE: VEGF-A stim...

Immune system's attack dogs kept on genetic leash

...the gene's protein," Peng says. When Peng's group disabled the gene in the immune systems of normal mice, they developed a lupus-like syndrome, with inflammation in the salivary glands, lungs, kidneys and several other organs. The protein made from the gene already was known to be a transcription factor -- ...

Gene mutation leads to super-virulent strain of TB

...1 operon, the collection of genes that researchers disabled in the TB bacteria, as an important virulence factor that helped the organism invade cells. Researchers expected that mutating the mce1 genes would impair the pathogen's ability to infect the mice. Instead, the bacteria became more deadly. "This ...

Gene may protect against heart disease rather than be harmful as previously thought

...ps have created mice in which the pathway has been disabled and the animals' blood vessels and arteries have actually more atherosclerosis. "The idea that NFkB has an anti-atherosclerotic effect is controversial," says Idel. "But, if it were true that the pathway had only harmful effects, then turning it off...

Study offers new insight into Rett Syndrome

...rotein for years, demonstrating that when MeCP2 is disabled in mice, the animals manifest Rett-like symptoms. But they couldn't figure out why this happens, and they couldn't find the exact genes that MeCP2 targets. At the same time, Greenberg, who also is a professor of neurobiology at Harvard Medical Scho...

RSRF-funded study leads to breakthrough for Rett Syndrome research

...with RSRF funding, demonstrated that when MeCP2 is disabled in mice, the animals manifest Rett-like symptoms. The next step was to figure out why this happens and what genes MeCP2 targets. Concurrently, Greenberg, who is also a professor of neurobiology at Harvard Medical School, was studying a central nervou...

PTEN and prostate cancer--the devil is in the doses

...eries of mice in which PTEN genes were selectively disabled in the prostate only. The researchers found that subtle reductions in PTEN dose did indeed produce progressive changes in the biology of the tumor, while mice having no functional PTEN genes showed the most invasive and aggressive cancers. These resu...

How genes orchestrate facial expressions

...e right eye looking right. When the two genes were disabled in mouse embryos, those nerve connections failed to form. "Without these neurons controlling the eyes, you would have cross eyes," Gaufo says. This portion of the study demonstrated how Hox genes direct the formation of specific nerves that control...

NSF awards $68 million for new engineering centers

...formation about these emerging technologies to the disabled and general public....

Enzyme discovery sheds light on causes of rare disease, cancer

...-including PHF9 itself--are mutated, the enzyme is disabled and the DNA repair pathway is disrupted. As a result, the person develops FA. Other researchers have found that similar disruptions in this DNA repair pathway can contribute to the development of ovarian, pancreatic, and other cancers in people who a...

Virus researchers close in on the secret life of DNA

...ia in order to cause disease, and that can also be disabled by modifying the protein's active site. Noting the similarity of E3L's active site to a site on a protein known as ADAR1 that has been proven to bind to Z-DNA, the researchers first replaced the active site in E3L with the ADAR1 site and found that v...

Early diagnosis of Usher syndrome type 1 made possible by new findings

...of the disorder, transmit their single copy of the disabled gene to their descendants. There are no data to indicate that there is an increased frequency of Usher syndrome in this population, only that the inheritance of the disorder is more clearly identifiable. There is indication, through the study's cont...

Researchers in Japan and UCSD discover novel role for pseudogenes

...ly expressed and highly visible. In mice with the disabled makorin1-p1 pseudogene, the expression of the makorin1 gene appeared weak and irregular in the diseased kidney tissue. Additional lab tests and experiments in mice determined that makorin1-p1 played a key role in regulating the stability of makorin1...

As harmful as osteoporosis but less well known - New research better explains sarcopenia

...-6 levels are often found in older persons who are disabled in activities of daily living. It has been proposed that the high risk of disability associated with high IL-6 serum levels is explained by the catabolic effect of IL-6 on muscle, which results in accelerated sarcopenia. However, the true effect of I...

Risk of future Exxon Valdez declines 92% since risk assessment, safety measures, says O.R. study

...escort tugs, while maintaining the ability to save disabled tankers. The Coast Guard Vessel Traffic Service now manages interactions between fishing vessels and tankers. SERVS has increased the minimum required bridge crew on board escort tugs to add additional error-capture capability. The International M...

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(Date:8/27/2014)... New York (PRWEB) August 27, 2014 ... filed in U.S. courts on behalf of women who ... uterine morcellation, Bernstein Liebhard LLP reports. According to court ... on August 18th in the U.S. District Court, Northern ... patient who claims the use of a power morcellator ...
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(Date:8/27/2014)... inherited from our parents shapes many aspects of our ... an epigenome that is set during development, but can ... perhaps by those of our parents and grandparents. , ... and supporting proteins that determine whether genes are expressed ... for our own health, but also that it may ...
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