Analysis of gene expression in lymphoid cells can determine lymphoma cancer
...ancing the myoD function," says Giordano, who also discovered the tumor suppressing gene Rb2/p130. "Our studies have demonstrated that in human tissue, CDK9 is a very important player in specialized tissue, as we see in this study with lymphoid tissue."...Scientists discover proteins involved in spread of HIV-1 infection
...ital in Montebello, Norway. Stenmark's group also discovered the same group of human VPS37 proteins and published their results in the September issue of Molecular Biology of the Cell . Says Sundquist, "In a general sense, I think that it is important to identify all of the cellular proteins that are involved...Green tea research leads to gum and other products
...ge of behavior protects the healthy cells. Dr. Hsu discovered that the polyphenols activate two separate pathways, one for normal cells and one for cancer cells. The polyphenols serve as a sentinel, separating cells with p57 from cancer cells, which lack p57. He found that while the normal cells are shuttled to...Analysis of biological clock may lead to greater understanding of human disease
...f the fragility of the global machinery. They also discovered that sensitivity analysis confirms the theoretical insight that hierarchical control is important for achieving robustness. Moving up the hierarchy of the system, searching for points of fragility, looking for the weak links, may be a way to show ho...APS awards more than $140,000 to minority students of physiology
... to develop into bone rather than fat. Her lab has discovered that activation of Wnt signaling inhibits differentiation of fat cells and prevents obesity in mice. Currently, she is testing whether Wnt signaling results in fewer fat cells and more bone forming cells in the marrow cavity. This work may provide a...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
... the University of Pennsylvania School of Medicine discovered that in ovarian cancer immune cells can change int...olecules with chemoattracting properties. The team discovered that beta-defensins produced by the tumor attract dendritic cells to the tumor and thus contribute t...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
... to as metabolomics. With this approach, "we have discovered potential biomarkers that could be diagnostic for ALS and are working to validate our findings," says Chris Beecher, Ph.D., vice president of biochemistry & technology at Metabolon, Inc., in Research Triangle Park, N.C. "We believe that the metabolom...New genetic research demonstrates possible cause of inherited form of Parkinson's disease
..."This is an extension of the genetic research that discovered the mutant alpha-synuclein gene and it is exciting to see how this information can be used to possibly determine the cause of Parkinson's disease." Blockage Causes Neuron Death Neurons that release dopamine, the neurotransmitter that c...Researchers uncover secrets of immune system's munitions factory
Howard Hughes Medical Institute researchers have discovered a new component of the machinery immune cells use to generate a remarkably diverse array of antibodies from a relatively small number of genes. The discovery reveals important links in the molecular pathway by which complex genetic alterations arm th...Discovery of new shrimp species adds to unique family
A University of Alberta researcher has discovered two new species of shrimp--adding to an unusual fa...cientifically known as alpheidae--and has recently discovered two new species. Shrimp from this family are diverse, ranging from one to nine centimetres in lengt...Meteorites supplied Earth life with phosphorus
University of Arizona scientists have discovered that meteorites, particularly iron meteorites, may have been critical to the evolution of life on Earth. Their research shows that meteorites easily could have provided more phosphorus than naturally occurs on Earth -- enough phosphorus to give rise ...Marathoning mice could have Olympian effects on obesity
...rd Hughes Medical Institute. Evans, Wang and team discovered that activation of the switch, a receptor called PPAR-delta, increases the rate at which the body burns fat. This makes PPAR-delta an exciting potential target for drugs that treat diabetes and lipid disorders. The team produced a genetically engin...UCSD biologists develop 'super-endurance' strain of mice
...ods than their normal counterparts, the scientists discovered that their super-endurance capabilities appear to ...byproduct. Two years ago, Johnson and his students discovered that "knocking out" the HIF-1 gene in the white blood cells of mice limited the tendency of the cell...Evidence for sympatric speciation by host shift in the sea
... to show that a new species of coral-dwelling goby discovered in Papua New Guinea is closely related to another species of goby found in the same area and that the two species diverged from each other just a few hundred thousand years ago. The new goby species inhabits just one species of coral--one that is not...No longer just for biology, RNA can now be built into 3-D arrays
...the strands to join into 3-D shapes. In 1987, Guo discovered that a bacteria-infecting virus possesses a biomol...ronment." Peixuan Guo, Purdue University "We have discovered a particular type of RNA molecule known as pRNA, or packaging RNA, that forms six-unit rings that ca...Synthesized molecules studied as weapon to stop cell division in cancer cells
...do not bend to the will of Pin1. The research team discovered that cis inhibits the Pin1 enzyme's function 23 times better than trans. "This is very exciting because it tells us something fundamental about the mechanism. The Etzkorn group tested the inhibitors in an ovarian cancer cell line. "That was the cell ...Engineering endurance: The future of the Olympics?
...ring activity. Randall Johnson and colleagues have discovered a protein found in skeletal muscle that profoundly influences muscle endurance, while Ronald Evans and colleagues genetically engineer muscle phenotype in a manner that dramatically improves endurance and running performance. Hypoxia (the physiologic...Carnegie Mellon scientists reveal ways of studying, resolving PCB contamination in US rivers
... and engineers from Carnegie Mellon University has discovered key aspects of processes that govern PCB fate in sediment and developed methods to monitor, measure, track and contain these synthetic compounds. These scientific sleuths are deploying everything from DNA fingerprinting to a fine mesh of carbon parti...Anticancer drug zebularine specifically targets tumor cells
...bularine's inhibition of DNA methylation was first discovered in experiments on a filamentous fungus by Eric Selker of the University of Oregon, said Jonathan Cheng, an M.D./Ph.D. student at USC who is one of the first authors on the Cancer Cell paper. "It was completely unexpected," Cheng says. "And we have si...Gold quantum dots have applications in biological labeling, nanoscale optics
...ectronics and in energy transfer pairs. "We have discovered a new class of quantum dots that are water soluble, strongly fluorescent, and display discrete excitation and emission spectra that make them potentially very useful for biological labeling," said Robert Dickson, associate professor in the School of ...