Brain Protein "Rescues" Neurons From Atrophy
...h a factor," Katz said. The key to the scientists' discovery was a new technique of providing neurotrophins to brain cells that, for the first time, allows researchers to determine precisely which cells received the substance. The technique involved first coating minute fluorescent latex particles with the neu......c medical centers leads to practical benefit. This discovery maywell change our understanding of the nature of addiction and lead to newtreatments for psychiatric disorders and Parkinson's disease. It once againshows how our nation's commitment to research is needed to provide practicalsolutions for common hea...New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...activity of BCR-ABL." According to Pendergast, the discovery offers the possibility of cancer treatments that eliminate drug-resistance by selectively rendering tumor cells vulnerable to normal cell death when treated with anti-cancer drugs. In the paper in Genes and Development, Pendergast and postdoctoral fe...Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"
...beginning to cross the difficult area between gene discovery and abnormalfunctions of the brain, and to open th... he said. The primary researchers involved in the discovery are Duke neurologistsStrittmatter, James Burke and Jeffery Vance. Other collaborators includeJan Eng...Tumor Suppressor Gene Located In Liver Cancer Cells
...ca Pharmaceuticals of Chesire, United Kingdom. The discovery that the gene -- mannose 6-phosphate/insulin-like ...nd discovered mutations in the tumor samples. The discovery of identical mutations in more than one tumor indicated potential "hot spots" -- regions of the gene...New 'Twist' In Proteins Offers Possible Route To Improved Antibiotics
...sebacteria are different from one another, but the discovery of this commonstructure in an enzyme critical to bacterial growth certainly offers considerablepromise."...Second Breast Cancer Gene Located
...t cancers." Futreal has had a hand in the discovery of both breast cancer genes. Asa member of the Sko...ancer center. "We look forward to helping put this discovery to use as we developbetter therapies and prevention strategies to protect all women from thisdisease...Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...troying, arthritis-likedisease in the animals. The discovery may provide a clue to the underlyinggenetic defect...immune disorders. The Duke researchers made the discovery while trying to understand therole of a gene of unknown function that seemed to be involved in the a...Heat-loving Microbe Repairs Its DNA With Light
... variety ofmicro-organisms," said Grogan, "but its discovery in S.acidocaldarius raises particular questions about what it takes tosurvive in geothermal habitats. For example, are we to infer thatUV radiation is a significant threat to survival in these high-temperature environments?" On one hand, it would s...Duke Researchers Find Second Gene Linked To Blood Vessel Disorder
...nked asecond gene to a rare bleeding disorder -- a discovery that offers insightinto how blood vessels form and heal in response to injury. The finding links a previously identified human gene called activin receptorlike kinase 1 (ALK1) to the disease hereditary hemorrhagic telangiectasia(HHT), a bleeding d...New Discovery About Genes Has Implications For Genetic Therapy
...science journal Nature . They also believe the discovery provides a window into how some of the earliest organisms evolved several billions of years ago since the introns function as very primitive genetic elements. Alan Lambowitz, Ohio Eminent Scholar in Molecular Genetics, along with doctoral student ......gan exploring the Movile Cave in 1986 followingits discovery by Romanian geologist Cristian Lascu. Theexplorations halted after Sarbu fled the oppression of theCeausescu regime, resuming in 1990. The current research is funded by the National ScienceFoundation with additional support through the Fulbright Pro...International Research Team Clones New Skin Cancer Gene
...er Genetics Program at the Yale Cancer Center. The discovery paves the way for novel approaches to preventing and treating basal cell carcinoma, according to David J. Leffell, M.D., associate professor of dermatology at the Yale School of Medicine and a co-author of the report. 3Although still several years ...Florida Researchers Discover Gene For Fatal Childhood Disease
...Americans have Chediak-Higashi syndrome, thegene's discovery could have far-reaching implications for tens of t...cations many lupus patients develop. "This discovery has the potential to be a treatment for lupus as itrelates to kidney problems," said Dr. Doyt Conn, ...Photosystem I -- An Intermediate Step -- May Not Be Necessary For Plants
...ossible," Owens said. Owens does not know how this discovery will fit into the larger puzzle of plant biology. .... "The framework that we have for evaluating this discovery is incomplete," he said. "No one knows where it will lead." The Oak Ridge researchers explained they...Surprising Protein Movement Seen In Cells
... move freely and rapidlywithin the structures. The discovery contradicts widely accepted models for the functionof the structures, or organelles, called the Golgi apparatus.There is no obvious explanation for why, despite their movement,the enzymes are not transported out of the organelle, as othermobile prote...Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report
DURHAM, N.C. -- In a discovery that defines a new message system insideliving cel...that control life processes. Although the discovery was made in bacteria, the team believes that humancells also use NO molecules as a genetic signaling...Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
DURHAM, N.C. -- In a discovery that defines a new message system insideliving cel...that control life processes. Although the discovery was made in bacteria, the team believes that humancells also use NO molecules as a genetic signaling...Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
...h as hormones. The scientists believe their basic discovery could eventually lead to newways to "turn off" can... itself is regulated within the cell. "While this discovery is clearly important in the signaling processes,we have a long way to go in understanding exactly ho...Newly Discovered Gene Halts Cell Division and May Have Cancer Link
...y have defects in the gene, known as MAD2. The new discovery may open the door to finding more effective ways to treat such tumors. "We think the MAD2 gene stops cells from dividing when doing so would leave the newly formed daughter cells without all the chromosomes they need to function properly," says Dr. ...