Enzyme's Structure Yields Blueprint For Antibiotic Resistance
... RNA. Such widespreadbiological activity gives the discovery importance for a wide range ofinvestigations. Discerning the common structure of such a large family of enzymes also providesan important clue to understand how proteins accomplish life's functions. Burleyexplains that although there are some 100,000...Structure Of Enzyme Involved In Gentamicin Resistance Revealed For First Time
...s have madesignificant achievements, including the discovery that DNA is the carrier ofgenetic information and the launching of the scientific field of modern cellbiology. The university has ties to 19 Nobel laureates, four of whom are oncampus, including the president, Torsten N. Wiesel, M.D., who received th...How A Common Protein Becomes A Cancer Killer
...r." Raines' research questions begin with the 1991 discovery that a ribonucleaseprotein in the Northern leopard frog possesses anti-cancer properties. The NewJersey-based biotechnology firm Alfacell Corporation, which is credited with thediscovery, is manufacturing a drug called Onconase that is currently inph...Scientists Discover How Bacteria Protect Themselves Against Immune System
...ct themselves againstthe human immune response - a discovery that opens the door for development of anew class of antibiotics to fight infection. In the study, to be published in the September edition of Proceedings of theNational Academy of Sciences, the researchers have discovered thatflavohemoglobin, a prot...Scientists Closer To Locating Gene That May Explain Cholesterol Absorption
DALLAS--September 1, 1998--In a discovery that may shed light on why peopleabsorb cholesterol at different rates, scientists from UT Southwestern MedicalCenter at Dallas and the National Institutes of Health have narrowed theirsearch for a gene responsible for abnormal cholesterol absorption...Gene Mutation Found For Common Form Of Mental Retardation
... give dramatic insight into brain development. The discovery that thisdefect causes severe cognitive problems, and occurs in a gene that normallyregulates neuron shape, gives a new look at how neurons interact in learning andmemory. Traditionally, mature neurons were thought to convey messages bychang...Research Team Finds Gene Causing Two Types Of Muscular Dystrophy
... for intervention using genetherapy." The current discovery caps a process that began 15 years ago when Brown met withmembers of a family affected by an unusual muscle disease characterized byweakness appearing in the lower legs in early adulthood. Searching the medicalliterature, Brown and his colleagues fo...Chumminess Of Roundworms Linked To Single Gene, Offering Insight Into Mechanisms Of Social Behaviors
...argmann's more immediate focus, however, is on the discovery that roundworms'feeding behavior is dictated by a ...nged on a single amino acid change. "The discovery that a clearly defined trait is accounted for by onegene--and by one nucleotide within that gene--wa...Loss Of Tumor Suppressor Gene Triggers Colon Cancer
.... We are working to findthe others," he said. The discovery also offers hope of finding new ways to treat coloncancer. Knowing that the c- MYC oncogene is one final link in the coloncancer chain "brings up an obvious and potentially powerful way todisrupt that interaction," Vogelstein says. Vogelstein's team......harmaceutical company to developdrugs based on our discovery of TTP's role in regulating TNF," Dr. Blackshearsaid. "This new understanding of TTP's function could improve our ability totreat patients with a number of serious diseases, so we want to put thisknowledge to work."...Scientists Find New Clues About Fatal Childhood Disease, Ataxia Telangiectasia
...cedby A-T patients. "It's a major leap to go from discovery of a defective gene tounderstanding how it affects cells," says Giovanna Spinella, M.D., of theNational Institute of Neurological Disorders and Stroke (NINDS), which helpedfund Dr. Shiloh's research. "This finding opens the door to studies of how th......olic energy and, thereby, weight loss. The discovery was made by M. Rocio Sierra-Honigmann, M.D., Ph.D.... as well as with experiments in rats. The discovery four years ago of a gene that produces leptin in micetriggered a flurry of research aimed at harness...New Evidence From Dinosaur Footsteps Show Massive Herds Once Roamed Northern Alaska
...knowndinosaur bone beds farther to the north. This discovery provides the first direct evidence thatdinosaurs were numerous and diverse in the Arctic 90-110 million years ago. Previously, therewas only one, poorly documented trackway on the Alaskan Peninsula. "This summer, we found dinosaurtracks from meat ......on supplied byRNA," says Dr. Bartel. The discovery in 1982 of ribozymes, a class of RNA that catalyzechemical reactions, has bolstered the notion that RNA came before protein, butmore challenges lay ahead for evolutionary biologists before they could espousethe RNA world view. For one, there are onl...Hyperforin Is A Key To St. John's Wort, Researchers Say
...ral Health Products announced today. "This discovery is extremely exciting for people seeking a dependableroute to a positive outlook on life," said Derrick DeSilva Jr., MD, a practicinginternist who teaches at JFK Medical Center in Edison, NJ, and is author of AskThe Doctor: Herbs & Supplements for Be...Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
...ystem with assay development and screening for the discovery ofnovel drug leads. The data to be presented demon...s the validation of atarget for antiinfective drug discovery by the regulated inhibition of thetarget in a pathogen during a systemic infection. In collaborati......of structure-baseddrug design, an approach to drug discovery that integrates advanced biology,biophysics and chemistry. The Company is concentrating on the discovery anddevelopment of drugs for the treatment of viral diseases, multidrug resistancein cancer, autoimmu......say to resolve, but weare moving from a scientific discovery to an engineering challenge." But the significance of the UCSF study, reported in the October issue ofNature Medicine, extends beyond the hope for an effective screening tool. Forthe assay has revealed stunning insights into the nature of th......to say whether the new Omma species has escaped discovery until now because it is extremely rare - or simpl...ch remain unknown and undiscovered. "After the discovery of the Wollemi pine, near Sydney, I'd expect to find anything anywhere," he says. In fact, Dr La...