Scientists discover role for c-myc gene in tumor angiogenesis
...study presents strong evidence to suggest that the disruption of c-Myc may prove successful as an anti-angiogenic tool in cancer therapy....Use of vitamin A cream may prevent skin cancer
...opment of a range of tissues; it is now known that disruption of this pathway can result in the formation of several tumor types. Basal cell carcinomas (BCC), the most common malignancy in humans, typically occurs in areas of chronic sun exposure. BCC is usually slow growing and rarely metastasizes, but it c...UT Southwestern researchers discover role of two genes involved in cholesterol excretion
...ceedings of the National Academy of Sciences. "The disruption of the two genes, Abcg5 and Abcg8, reveals their crucial role in biliary cholesterol secretion," said Dr. Liqing Yu, an instructor in the Eugene McDermott Center for Human Growth and Development and in molecular genetics and lead author of the study....JCI Table of Contents, November 18, 2002
...eam of insulin signaling, but resultsfrom targeted disruption in mice of PI 3-kinase function--both globally or inspecific tissues --have failed to yield a clear picture of when and where PI3-kinase is required to mediate insulin's function. Taking advantage of thefact that systemic administration of adenovirus...Tailor-made sugar coated proteins manufactured in novel E. coli system
...and muscular dystrophy have already been linked to disruption of the delicate balance of sugars displayed on the surface of proteins. Deciphering these complex interactions will be significantly aided by the new tool our research has developed." Professor Brendan Wren of the London School of Hygiene and Tropica...Science picksLeads, feeds and story seeds (December 2002)
...ctivities can continue after the shaking with less disruption like power lines, transportation corridors, and other vital infrastructure. The updated versions of the maps color-coded (red is high; blue is low) as to the level of seismic hazard are now available at http://geohazards.cr.usgs.gov/eq/ . In th...JCI table of contents, December 15, 2002
...https://www.the-jci.org/press/15887.pdf Targeted disruption of H3 receptor results in changes in brain histaminetone leading to obese phenotype Histamine has numerous functions in the mammalian immune, digestive, andnervous systems. Previous studies suggested that histamine may regulate foodintake, a functio...Wetlands clean selenium from agricultural runoff
...m the Central Valley to the Delta. Farmers say the disruption of the irrigation drain, however, allowed salt to build up in the soil, leaving their land fallow. The situation was bad enough that, last month, the federal government agreed to pay $107 million to San Joaquin Valley farmers for 34,000 acres of sal...Endangered northern right whales exposed to paralytic shellfish poisoning
...r susceptibility to disease, reproductive failure, disruption of migration and mechanical damage, e.g., by collisions with ships or fouling in nets and other fishing gear. For example, recovery from dives during periods of PSP exposure would likely be longer than normal, and increased time at the surface would ...Mutation in DKC1 gene can cause rare aging disease and cancer
...pectedly, they also showed that DC was caused by a disruption in ribosome function and not due to shortened telomeres (the distal end of a chromosome arm) as previously hypothesized. Their results, published in the January 10 issue of Science, may have implications for development of drugs that kill cancer cell...Suppressing immune system reverses otherwise untreatable case of blood disease
...rmal in people with TTP, presumably as a result of disruption by the immune system. Without it, the protein called von Willebrand factor is not regulated and therefore sticks to itself, forming large clumps, or blood clots, that often lead to stroke or heart attack. "The discovery of this protein really helps u...Scientists uncover 'time for bed' molecules
...the process of sleep regulation is exciting as the disruption of normal sleeping patterns is a common symptom in a variety of illnesses ranging from arthritis to Parkinson's disease as well a being very common in sufferers of depression....Abnormalities in cellular anchoring protein cause fatal heart syndrome
..., called long QT syndrome (LQTS), can be caused by disruption of proteins that anchor ion channels in the cell. The finding is noteworthy because most cases of LQTS, and some other known heart conditions, have involved defects in ion channels -- proteins involved in moving potassium and other ions in and out o...Scientists identify same gene in mice, humans leading to heart failure
...mutation of a protein called phospholamban and the disruption of calcium regulation in the heart," says Dr. David MacLennan, U of T professor in the Banting and Best Department of Medical Research and one of the senior authors in a Feb. 28 paper in Science. "Scientists at U of T and elsewhere have learned how t...JCI table of contents, March 3, 2003
...//www.the-jci.org/press/16492.pdf Liver-specific disruption of the peroxisome proliferator receptor gamma indiabetic mice improves fatty liver, but aggravates hyperglycemia CONTACT: Frank J. Gonzalez NIH, National Cancer Institute Laboratory of Metabolism Building 37, Room 3E-24 9000 Rockville Pike Bethesda,...Oxygen deficiency is an endocrine disruptor in fish
...n to believe that hypoxia may also cause endocrine disruption in other fish and amphibian species, as well as in...g factors," Wu continues. Most cases of endocrine disruption occur on a local scale, in a particular river or estuary where chemical contamination is found. Hypo...Component in plastic bottles found to cause abnormal pregnancies in mice
...ith cell division in the eggs of female mice. The disruption of cell division can result in an abnormal number of chromosomes in the eggs, a condition known as aneuploidy, which is the leading cause of mental retardation and birth defects in humans. Down syndrome is an example of a disorder caused by the addi...Achillion and UMBC collaboration identifies new class of agents with potential to treat HIV
... anti-HIV activity of inhibitors was indeed due to disruption of the HIV-1 capsid protein. Three patents have been filed based on the findings reported in today's publication. "These findings offer exciting opportunities for the discovery of new drugs to treat HIV," said Dr. Rice. "These compounds are part of t...Genetic abnormalities found in some ALS patients
...gements contribute to ALS. "They may result in the disruption or alteration of susceptibility genes that haven't been identified yet," Meyer said. "Another possibility could be that an underlying mechanism of ALS that has yet to be determined could promote the development of these chromosomal abnormalities." Me......ated animals," says Dr. Giannakakou. "Microtubule disruption results in the down regulation of HIF-1a. While this effect is not unique to 2ME2 when compared to Taxol or vincristine in preclinical models, it is the most more potent HIF inhibitor of all the microtubule-targeting chemotherapeutic agents tested ...