Healthy neighbors rescue degenerating motor neurons
...d to a body of evidence that shows that it's not a disruption of the normal function of mutant SOD1 that causes disease. Rather, it appears to be some abnormal property of the protein conferred by these mutations." One major scientific question, said Goldstein, was whether the abnormal SOD1 in the motor neuro...UC Riverside to convene conference on genetically modified organisms, Oct. 14-17, 2003
...e socially and environmentally disruptive and such disruption often has unexpected and unhappy consequences. Not just economists, but everyone, needs to pay attention." Sutch noted that GMOs play a role in the global economy. "Much of the world's agricultural output crosses borders to reach the final consumer...JCI table of contents, 15 October, 2003
...tional analyses demonstrating the mutation-induced disruption of HESX1/TLE1 interaction and transcriptional repression in cultured cells. These results provide a striking example of a clinical disorder associated with the loss of repressor/corepressor interactions. Further study of HESX1 mutations should reveal...Proteins enable HIV to override cell's defenses
...tory experiments, Dr. Yu's team further found that disruption of the Cul5-SCF function makes HIV less infectious and less able of suppress APOBEC3G and its protective properties. HIV infectiousness was reduced 90 percent when Cul5 mutants were over expressed in combination with APOBEC3G. Dr. Yu and his collabo...President Bush to present DuPont with National Medal of Technology
...and refrigeration equipment, avoiding the societal disruption and expense of developing wholly new technology. In the United States alone, that equipment base totaled more than $135 billion including 150 million automobile and small truck air conditioning systems, 80,000 building chillers and 69 million home ...US crackdown on bioterror backfiring
... someone killed five people and created widespread disruption by posting envelopes of anthrax around the US. Coming just weeks after 9/11, the attacks shone a glaring spotlight on the risks of disease research. The authorities decided far tighter control was needed over biologists withaccess to dangerous pathog...DuPont awarded highest US honor for technological innovation
...and refrigeration equipment, avoiding the societal disruption and expense of developing wholly new technology. In the United States alone, that equipment base totaled more than $135 billion -- including 150 million automobile and small truck air conditioning systems, 80,000 building chillers, and 69 million ho...Diet may improve cognition, slow aging, and help protect against cosmic radiation
...f developmental exposure to these chemicals is the disruption of the normal differences between males and females," says Carr. "It's a subtle effect because exposure to these chemicals doesn't produce any significant effects on brain neurochemistry within each sex."...New technique helps shed light on progression of dementia
...odel to look at the effects of cerebral blood flow disruption on mental functions that require intact nerve cells releasing acetylcholine in the cortex. In patients with dementia, blood flow in the brain may slow down as a result of mini-strokes and the abnormal regulation of blood vessels, which contributes to...Social mothers appear to be better mothers
...accidents and a range of mental disorders, and the disruption of social ties due to death, divorce or separation is a major source of stress," the study notes. Although infant survival rates in humans have yet to be linked directly with social factors, research has shown that low-income women with extensive soc...UT Southwestern researchers' discovery may lead to gene targets for new form of contraceptive
... exists in human sperm cells, so it is likely that disruption of CatSper2 would result in infertility in men as well. If a contraceptive drug could be designed that would bind to the protein and block its function, then those sperm cells would be rendered ineffective or infertile." Such an ion channel-blocking ...Communication is key to successful U.S. SARS quarantine
...ective while causing as little social and economic disruption as possible." U of L's Institute for Bioethics, Health Policy and Law conducts interdisciplinary research in emerging areas of bioethics, health sciences, public health, law, and related fields, with special attention to relevant legislative and regu...'Suicide proteins' contribute to sperm creation
...vidual spermatids--also occurs in mammals, and its disruption is associated with male infertility. Hay's group studied the consequences of inhibiting caspase activity in the male germline cells of fruitflies and found that individualization depends on caspase activity. The researchers went on to character...JCI table of contents, December 15 2003
... a targeted mutant mouse model with a heterozygous disruption of beclin 1 and observed an increase in cellular p... TITLE: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene AUTHOR CONTACT: Beth Levine Columbia University College of Ph...Autophagy active in tumor suppression
... a targeted mutant mouse model with a heterozygous disruption of beclin 1 and observed an increase in cellular proliferation and the frequency of spontaneous malignancies and a reduction in autophagy in vivo. The report demonstrates that beclin 1 is a haplo-insufficient tumor-suppressor gene and suggests that a...Researchers identify key player in respiratory memory
...a person may take deeper breaths. If the breathing disruption is experienced regularly, the respiratory system remembers the disruption and most likely will respond more vigorously in the future. Researchers call this change in neural b...Quark Biotech generates a cholesterol-free mouse
...olic diseases." The resulting mild effects of the disruption of desmosterol reductase in this model contrasts dramatically with the autosomal recessive malformation syndrome resulting from a deficiency of this enzyme named desmosterolosis. Since only two cases have been identified, the desmosterolosis phenotyp...OHSU-led research examines role of copper, iron in diseases
...rstanding metal homeostasis in human cells and its disruption not just in Wilson's and Menkes diseases, but also diseases such as hemochromatosis, Lou Gehrig's disease and even mad cow disease, all of which may be linked to errors in metal metabolism. The research explores molecular mechanisms regulating prima...JCI table of contents, February 2, 2004
...ity-induced insulin resistance. TITLE: Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance AUTHOR CONTACT: Jens C. Brning Institute for Genetics, Cologne, Germany. Phone: 49-221-470-2467 Fax: 49-221-470-5185 E-mail: jens.bruening@uni-koeln.de View the PDF of this art...Possible mechanism for link between diabetes and Alzheimer's disease discovered
...ore, various research findings have suggested that disruption of the insulin signaling system may occur in such disorders as Alzheimer's disease and Parkinson's disease. In fact, at least one large European study found people with diabetes to be at least twice as likely to develop Alzheimer's disease as someone...