JCI table of contents, 16 February 2004
...hindbrain, is often the target in ataxia and how a disruption in this region results in ataxia is of considerable interest. A report by K. George Chandy and colleagues from the University of California Irvine in the February 16 issue of the Journal of Clinical Investigation links ataxia to enhanced hyperexcit...Study examines whether giving good bacteria reduces infections
...natural bacterial flora in the intestinal tract, a disruption with widespread consequences including making the intestinal lining more susceptible to bacterial invasion, impacting the health of colon cells and disarming the immune system. "We kill all the normal bacteria in our GI tracts, allow these abnormal b...Deficits associated with prenatal alcohol exposure can be seen as early as infancy
...y found that prenatal alcohol exposure resulted in disruption of this fundamental cognitive process." Specifically, infants identified as "high risk" had significantly higher levels of arousal yet responded more slowly to stimuli than did infants identified as "low risk." Higher levels of behavioral arousal, c...Memories are harder to forget than currently thought
...S study, however, the Penn researchers showed that disruption of a "re-remembered" memory was not permanent. "When we looked at mice 21 days after they were treated with anisomycin to block the reconsolidation of a memory, we showed that they could, in fact, remember the original learned behavior," Lattal sai...'Protein-only' prions confirmed in FSU yeast study
...g prions themselves. Invariably, this leads to the disruption or alteration of normal cell function, King said. Another key find in the FSU study is that prions formed in host cells are amyloids, a family of fiber-forming proteins that often are associated with neurological disorders in humans. Amyloid plaques...AIDS drug helps to keep HBV at bay during chemotherapy for breast cancer
...on, hepatitis, severe hepatitis and any consequent disruption to the chemotherapeutic regime. "We found that lamivudine significantly reduced the incidence of HBV reactivation, and that the incidence of hepatitis from all causes was reduced," said Dr Yeo. Only two patients out of the 27 receiving lamivudine suf...Report in BioScience details global decline of nonmarine mollusks
...ollusks is due directly to habitat destruction and disruption of natural ecosystem processes. As an integral component of healthy ecosystems, molluscan diversity is valuable both for its own sake and as an indicator of conditions that may affect other species, including our own. Nonmarine mollusks are members ...Vanderbilt doctors find citrus soda interacts with cyclosporine, maybe statins
...of other drinks containing citrus products, on the disruption of excretion and absorption of cyclosporine and certain other prescription drugs. Although there isn't a body of published evidence yet, there is strong evidence to suggest beverages containing bergamottin also alter the absorption and excretion of s...Yellowstone's long-distance travelers in trouble, study says
... designed to understand possible petroleum-related disruption to migratory caribou, no scientific literature exists to assess possible energy-related effects on migration in the GYE," Berger said. To protect these traditional migrations, the authors of the study suggest that a network of strategically planned ...Traditional fishing destroys corals - new research
...sh research team has found the comparatively minor disruption to the marine environment by subsistence fishing can bring disastrous consequences. The scientists, from the Universities of Newcastle upon Tyne and Oxford, spent two years studying the impact of traditional fishing in Fiji, where they witnessed heal...Dartmouth Medical School awarded $9 million grant for genomics research
...lable to the public, will: Pursue the systematic disruption of genes through targeted gene replacements; Produce a platform for electronically capturing community feedback and data about the existing annotation; Provide a baseline analysis of gene expression under a variety of growth conditions and; Generate ...Study of proteins offers insights into organization of biological networks
...used connection length to increase. "The extent of disruption caused by removal of hubs is clearly greater than that caused by removal of non-hubs," Vidal remarks. "It's as though one closed a main road in a city, forcing traffic to follow a lengthy detour to reach its destination." Analyzing data gen...Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia
...form of T cell leukemia. The findings reveal that disruption of immune cell differentiation is central to disease progression and provide new avenues for development of future therapeutics. T cell acute lymphoblastic leukemia (T-ALL) accounts for 10%-15% of pediatric and 25% of adult ALL cases. A gene called T...UNC scientists discover molecular pathway leading to nerve growth and regeneration
..., this is not the case with the spinal cord, where disruption of connections from injury leads to paralysis. "The results of this study allow us to know more about how to promote axon growth and regeneration in the spinal cord," said Dr. Fengquan Zhou, a postdoctoral fellow of the Spinal Cord Research Foundatio...Scientists discover key step in the development of nerve cells controlling autonomic functions
...lleagues have demonstrated for the first time that disruption of this gene causes a dramatic loss of these particular nerve cells. During the development of the nervous system, there are a number of critical events that generate different types of nerve cells in particular locations of the brain and at particul...Good bacteria trigger proteins to protect the gut
...cient mice. The researchers observed a generalized disruption in proliferation and differentiation of intestinal epithelial cells in the MyD88-deficient mice, implicating TLRs in overall maintenance of the tissue. The animals' intestines were particularly sensitive to radiation, which could be attributed in par...Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
... Gregory Freund, a clearer picture is emerging: A disruption of signaling proteins in the immune system may be responsible for the inflammation that makes someone with type 2 diabetes feel sick and increases the risk of serious complications. Freund, the head of the pathology department in the University of Il...Coordinating power of circadian rhythms keeps estrus and pregnancy on track
...d graduate student Brooke H. Miller found that the disruption of the Clock gene resulted in abnormal estrous cycles (the mouse equivalent of human menstrual cycles), primarily due to a defect in the control of hormone release by the brain. The researchers also found that Clock mutant females exhibited high rate......ent angles, under real conditions and with minimal disruption to the specimen. "Over the years we've seen current microscopes falling short of what the scientists need. We designed SPIM with EMBL biologists to make sure that it was completely suited to their needs," says EMBL scientist Ernst Stelzer, whose grou....../22685.pdf Galling Gallstones TITLE: Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis AUTHOR CONTACT: Martin C. Carey Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA Phone: (61...