Other highlights in the August 18 JNCI
...ock in Rostock, Germany, and colleagues found that disruption of oncogenic RET signaling is associated with decreased cell viability and cell proliferation in vivo , which indicates that RET stimulates cell proliferation and inhibits apoptosis. The authors suggest that RET signaling should be investigated furt...Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
...ngletary. "However, the results show that tubulin disruption may be an important explanation for SUL's antiproliferative action." "These findings are significant since SUL's actions appear similar to a group of anticancer drugs currently in use, such as Taxol," Singletary said. SUL is studied extensively for i...Flame retardants found on supermarket shelves
...e they have been associated with cancer, endocrine disruption and impaired brain development in animal studies, according to the researchers. The European Union has banned two types of PBDEs the penta and octa formulations and is currently considering a ban on a third type, the deca formulation. Officials i...A new protein is discovered to play a key role in cancer progression
...h Factor-beta (TGF-b). The cause of this signaling disruption of the normal cell cycle has not been fully understood. For the first time, scientists at Memorial Sloan-Kettering Cancer Center have discovered the biologic function of the cytoplasmic form of the Promyelocytic Leukemia protein (PML), and identified...Rice finds 'on-off switch' for buckyball toxicity
...that cell death in the tests occurred via physical disruption of the cell membrane by oxygen radical species generated by the buckyballs. Colvin and her colleagues emphasize that the study only fills in part of the puzzle regarding fullerene toxicity. For example, because cytotoxic studies look only at cells in...Alzheimer's disease is not accelerated aging
... "What we call aging is actually a conjunction of disruption of two different brain systems," said William Jagust at the University of California, Berkeley. "Randy has done a very nice job of showing how these two systems produce different behavioral changes and are probably related to different pathological p...Potential for enhanced sequestration of carbon in soils supports evaluations
... ongoing global warming that is causing ecological disruption and threatens human populations. The researchers note that a variety of land-use practices have apparently favorable potential for increasing carbon dioxide uptake, including intensifying cropping, adding organic material to soil, conservation tillag...