JCI table of contents, 1 July 2004
...e fracture. A great deal of research has gone into dissecting the molecular underpinnings of this debilitating and painful disease. One gene that has been implicated in bone resorption diseases is platelet-activating factor or PAF. Now, Satoshi Ishii and colleagues, at the University of Tokyo, provide a potenti......e fracture. A great deal of research has gone into dissecting the molecular underpinnings of this debilitating and painful disease. One gene that has been implicated in bone resorption diseases is platelet-activating factor or PAF. Now, Satoshi Ishii and colleagues, at the University of Tokyo, provide a po...Inflammation, hypertension are focus of major new MCG research program
...ressure regulation itself." So the researchers are dissecting the relationship from different angles, from the psychosocial stresses that can elevate pressure to events within blood vessel walls that can keep it elevated. Dr. Brands' is using the male mouse's territorial instincts to look at whether interleukin...Estrogen receptor-a disruption and vasodilation in coronary arteries
... placed in cold saline solution. With the use of a dissecting microscope, coronary arteries were dissected free of surrounding myocardium and cannulated. Arteries that exhibited leaks were discarded and the remainder pressurized. Spontaneous tone was ensured between the WT and ERKO mice. Evaluation of eNOS an...Study reveals genetic activity of key step in malaria parasite's cycle
...San Francisco. "This work lays the foundation for dissecting the mechanisms the transcription factors -- that ...these zones of instability lays the foundation for dissecting the molecular mechanism by which malaria evades host immune processes, and may lead to better select...Deer help disperse seeds--including noxious weeds
...yers, the graduate ecologist spent countless hours dissecting deer pellets. The bad news, says Vellend: "Unfortunately, many of the seeds we're finding in deer feces are from noxious weeds, including four of the top 20 invasive plants of greatest concern in New York state. The multiflora rose, for example," he...Scientists demonstrate new method for discovering cancer gene function
BOSTON--Using a new approach for dissecting the complicated interactions among many genes, scientists at Dana-Farber Cancer Institute have discovered how a common cancer gene works in tandem with another gene to spur the unchecked growth of cells. The researchers say the technique was so usefu...Seeking the cause of a mysterious whale disease
...le strandings to develop a systematic protocol for dissecting the whale hearts, which Dr. Bossart hopes will reveal the cause of the disease. With an increasing rate of emerging diseases in whales and other marine mammals, researchers are rallying to come up with cures as well as new tools for monitoring and di...Key to hepatitis virus persistence found
... says. NS3/4A will be a valuable tool in further dissecting the roles of viral proteases and their host cell targets, says Dr. Gale. For example, the scientists plan to use NS3/4A to hunt for the still unknown host cell enzyme responsible for activating IRF-3. Conceivably, Dr. Gale explains, future therapeuti...UT Southwestern researchers identify gene that could have important role in human wasting disorder
...scovered. "This study illustrates the way in which dissecting a basic problem in developmental biology can lead to unexpected connections to human disease," said Dr. Eric Olson, chairman of molecular biology and senior author of the study, which appears in today's issue of Cell. "Who could have ever anticipated...Digital X-ray microtomography yields stunning views of limb regeneration
... changes inside the regenerating forelimbs without dissecting the tissue as it is done in conventional analyses. "Scientists previously thought that regeneration progressed in a continuous directional manner, from the amputation site to the farthest distal point," said Simon. The Northwestern researchers fo...UT Southwestern scientist helps identify gene that may lead to treatments for sleep disorders
... of using a primitive organism like a fruit fly in dissecting signaling pathways that are relevant and related to the genes in human beings and that we know are involved in both the developmental biology of human beings as well as in cancer," said Parada, who also is director of the Kent Waldrep Center for Basi...New screening method may speed hunt for disease-causing genes
...cians in her laboratory to spend hundreds of hours dissecting thousands of flies. The goal was to count each of the fly's artichoke-shaped ovary's ovarioles in order to exactly locate the genes in the genome. McIntyre and Wayne expect to continue their investigation of this new technique by studying whether the...New screening technique may speed hunt for genes
...cians in her laboratory to spend hundreds of hours dissecting thousands of flies. Each dissection involved picking apart a 3-millimeter fly under a microscope using two needles attached to toothpicks. The fly's ovary is an artichoke-like structure occupying most of its abdomen. The goal was to count each of the...New amino acid discovered; Fundamental building block of life
... 23rd or a 24th. "With so many researchers dissecting so many genomes now, it's reasonable to suggest that there might be more waiting to be found. "I think this work will cause researchers to start looking at genetic seque...Ambushing prey may make snakes vulnerable
...g field observations and on data frommeasuring and dissecting more than 18,000 preserved specimens. Thetraits ranged from foraging behavior (ambush vs. active hunting) toreproduction type (egg-laying vs. livebearing) to use of 25 habitattypes (such as grassland, forest and swamp). Reed and Shine found two main ...New technique speeds gene research in mammalian cells
... flies, and worms still have much to contribute to dissecting the complex genetic networks that control life. However, the new technique may well inspire researchers working with human and other mammalian cells to attempt genetic-style experiments that they could only have dreamed of just a few years ago....Staph bacteria are prolific gene swappers, researchers show
.... "DNA microarrays provide a finer microscope for dissecting bacterial genetics, and permit a rational strategy for vaccine and drug design."...New finding accelerates discovery of disease genes and human population history
...s major implications for mapping disease genes and dissecting human population history. It suggests that mapping the genes for common diseases might be much easieras much as 8 times easier in fact-and more manageable and practical than previously thought. It also suggests that it is not necessary for every si......ings, we provide an initial motivation for further dissecting two distinct receptor systems in terms of potential drug discovery programs." Rosenfeld's research group included his former UCSD colleague Toshimitsu Kishimoto, who is now at Yoshitomi Pharmaceuticals in Japan, and Jelena Radulovic and Joachim Spie...