New findings are a window into the late stages of 'Lou Gehrig's' disease
...They believe their approach can reveal some of the distinct changes that underlie the terminal stages in the d...of the gray matter components of ALS pathology; a distinct signature for familial ALS and sporadic ALS spinal cord gray matter gene expression was discerned (a...Examining cardiac performance of tunas at the cellular level
...nd mackerel. Conclusions This study reveals that distinct cellular differences in the expression of a key protein SERCA2 are associated with the beat-to-beat contraction of tuna and mackerel hearts. It suggests that there are fundamental differences in the way these fish initiate myocyte contraction, and p...JCI table of contents, February 2, 2004
... pathways: STAT1/3 and SHP2/ras/MAPK. However, the distinct downstream effects of these two pathways on bone d...otein 130 regulates bone turnover and bone size by distinct downstream signaling pathways AUTHOR CONTACT: Natalie A. Sims The University of Melbourne, Fitzroy, ...Scientists report first sequencing of environmental genome
... back together, the snippets fell easily into five distinct genomes, four of them unknown until now. "This is ...nes into tiny pieces, and trying to sort them into distinct genomes. But it works, Banfield said, "at least with the small number of distinct organisms in this ...New study shows Neanderthals were not our ancestors
...gin model, which views Neanderthals as a separate, distinct species. The research will be published in the Proceedings of the National Academy of Sciences. The scientists, led by Katerina Harvati of New York University, used a new technique known as geometric morphometrics to measure the degree of variation ...Global warming may cause songbirds to avoid certain foods
...keen capacity to learn." While the birds showed a distinct preference for caterpillars low in tannins and phenolics, they also showed a preference for foods they had eaten previously. "Previous experience does affect their preferences," Mller said. So what does all this mean? According to McWilliams, it c...Collaborative research initiative aims to cut drug development time in half
...nd Founder of MRF. " But this kind of siloing is a distinct disadvantage when it comes to complex diseases like MS. To solve multifaceted problems requires coordination among the most accomplished specialists in multiple disciplines. That collaboration between disciplines is what MRF is about," Johnson contin...Understanding urinary tract infections
...90 percent of all UTIs, pass through at least four distinct developmental stages during the course of an infection. Researchers hope to further define these stages and use them as guides in the search for new drugs. The study, to be published this week in the early online edition of the Proceedings of the Nat...New study finds evolutionary diversification in Hawaiian spiders
...n Hawaii. The spiders can be grouped into four distinct ecological types, or ecomorphs: the "green" type, which dwells on leaves; "maroon," which lives mostly on moss; "small brown," which lives among twigs; and "large brown," which dwells on tree bark. Gillespie found that spiders can evolve and differ...Are fish made of maple leaves?
...tic life. Similar to baking soda, NaH 13 CO 3 has distinct carbon atoms (13C), with one neutron more than is typically found in the most abundant form of carbon (12C). During photosynthesis 13C is taken up by plants, providing a unique signature that can be traced as it moves through the food web. By labelli...Parasite's enzyme structure helps address a public health issue
..., we've been able to place a number of protozoa in distinct evolutionary families. This is the first time that this enzyme has been used to do this," says Anderson. "It's an important distinction that helps classify the protozoa, and helps us design more effective drugs to combat them." To discover DHFR-TS'...A viral cure for type 1 diabetes
...d completely abolished the diabetic process in two distinct mouse models. This protection against the development of type 1 diabetes correlated with a reduced number of autoaggressive CD8 T cells in pancreatic islets. Increased production of the chemokine CXCL-10 in pancreatic lymph nodes redirected cells of...JCI table of contents, January 2, 2004
...d completely abolished the diabetic process in two distinct mouse models. This protection against the development of type 1 diabetes correlated with a reduced number of autoaggressive CD8 T cells in pancreatic islets. Increased production of the chemokine CXCL-10 in pancreatic lymph nodes redirected cells of...OHSU team discovers compound that lacks estrogen's risks
...placement therapy, Kelly said. STX is structurally distinct from tamoxifen and raloxifene, and it's about 10 times more potent than estrogen and has the potential to be more effective at maintaining cognitive performance of postmenopausal women. "Women that don't have hormone replacement therapy have been k...'Mad cow' mechanism may be integral to storing memory
... to maintaining long-term memory contained certain distinct prion signatures. The protein, CPEB, resides in central-nervous-system synapses, the junctions that connect neurons in the brain. Memories are contained within that intricate network of approximately 1 trillion neurons and their synapses. With experi...Scientists discover way to streamline analysis of maize genome
... filtering and High-C0t selection target somewhat distinct but overlapping regions of the genome and therefore could be used together to help identify nearly all of the genes in maize as well as their genomic structures. This finding is significant because the maize genome, which includes about ...'Panning for gold' in the maize genome
...ctions. Each method was found to enrich for distinct but complementary regions of maize's 10-chromosome genome. Combined, the methods could cut the amount of sequencing necessary to find all of the maize genes to about one-fourth of what it would take to sequence the entire genome. As both meth...Other highlights in the December 17 issue of JNCI
...the sun are rare. The discovery "strongly suggests distinct genetic pathways leading to melanoma," say study authors Janet L. Maldonado and Boris Bastian, M.D., of the University of California at San Francisco, and their colleagues, who looked at 115 patients with primary invasive melanomas. "The frequent occ...'Suicide proteins' contribute to sperm creation
...lators are recruited through different pathways at distinct points in time and space to create individually packaged, free-swimming sperm, a distinctly non-apoptotic process. Insights into the molecular basis of caspase activation in sperm individualization could provide clues to male infertility and sug...Map of genes in plant root yields new tool for exploring tissue development
...velopment. Benfey and his colleagues also detected distinct clusters of gene expression, in which different types of root cells tended to express particular sets of genes. Such patterns, he said, will prove valuable to biologists seeking to better understand the genetic machinery of development. And, the scie...